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EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer

By NewsCancerJune 23, 20260

Radioresistance in colorectal cancer (CRC) remains a critical clinical challenge, with underlying mechanisms involving deoxyribonucleic acid (DNA) damage repair, metabolic…

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Browsing: lactatemediated

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMGB1 and HIF-1α to confer radioresistance in colorectal cancer

FDA approved a revolutionary cancer drug. Insurance wasn’t ready

2025/26 in review: Cancer Research UK drives major progress against cancer – Cancer Research UK

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Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency

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Chemogenomic maps reveal a PRDX1-dependent iron–damage axis in the DNA damage response

Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency

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FDA approved a revolutionary cancer drug. Insurance wasn’t ready

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Chemogenomic maps reveal a PRDX1-dependent iron–damage axis in the DNA damage response

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Browsing: lactatemediated