A life–changing early diagnosis
Annette’s story shows why this research is so important.
Since she did not have a family history of the disease, she would not have been referred for genetic testing or screening. Without BCAN-RAY, she would have waited another decade for her first routine mammogram.
“When the mammogram picked up my cancer, it was undetectable by any other means. If I’d waited, it would have grown and changed my prognosis. It could have been a completely different story,” she says. “It was caught early, meaning it could be removed, and preventative treatment was available.”
Annette had two surgeries, followed by radiotherapy and is now on preventative hormone therapy for five years.
“Early detection may have saved Annette’s life, and we want to offer that same chance to many more women,” says Howell.
Looking ahead for BCAN-RAY
Of the 140 women identified as having an increased risk, 137 have already had consultations about ways to reduce their risk, including lifestyle changes and medication. 59 women have already had their first mammogram. Annette is the first to be diagnosed with breast cancer at an early stage through the study.
Annette says taking part has given her reassurance not only for herself but for her daughters, aged 13, 11 and 8. “I am so grateful for this study and future studies like it, so that I know my daughters will be well looked after.”
Further work is needed to refine the tools created as part of this study before they can be rolled out more widely. But this research is helping move us towards a future where cancer prevention, diagnosis and treatment are much more personalised. Sarah’s legacy continues to drive progress for women at risk of breast cancer.

