Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396–401 (2004).
Google Scholar
Zhou, F. et al. Periostin promotes EMT via inhibition of RIN1-mediated endocytosis of EGFR in gliomas. Holistic Integr. Oncol. 1, 19 (2022).
Google Scholar
Gimple, R. C., Yang, K., Halbert, M. E., Agnihotri, S. & Rich, J. N. Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity. Nat. Rev. Cancer 22, 497–514 (2022).
Google Scholar
Wang, M., Qin, Z., Bian, X. W. & Shi, Y. Harnessing chimeric antigen receptor macrophages against solid tumors. Cancer Commun. 45, 1344–1366 (2025).
Google Scholar
Namkoong, S., Ho, A., Woo, Y. M., Kwak, H. & Lee, J. H. Systematic characterization of stress-induced RNA granulation. Mol. Cell 70, 175–187 (2018).
Google Scholar
Jain, S. et al. ATPase-modulated stress granules contain a diverse proteome and substructure. Cell 164, 487–498 (2016).
Google Scholar
Ivanov, P., Kedersha, N. & Anderson, P. Stress granules and processing bodies in translational control. Cold Spring Harb. Perspect. Biol. 11, a032813 (2019).
Google Scholar
Jia, Y. et al. Stress granules in cancer: adaptive dynamics and therapeutic implications. iScience 27, 110359 (2024).
Google Scholar
Redding, A. & Grabocka, E. Stress granules and hormetic adaptation of cancer. Trends Cancer 9, 995–1005 (2023).
Google Scholar
Li, T., Zeng, Z., Fan, C. & Xiong, W. Role of stress granules in tumorigenesis and cancer therapy. Biochim. Biophys. Acta Rev. Cancer 1878, 189006 (2023).
Google Scholar
Badgley, M. A. et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368, 85–89 (2020).
Google Scholar
Yang, W. H. et al. The Hippo pathway effector TAZ regulates ferroptosis in renal cell carcinoma. Cell Rep. 28, 2501–2508 (2019).
Google Scholar
Hassannia, B., Vandenabeele, P. & Vanden Berghe, T. Targeting ferroptosis to iron out cancer. Cancer Cell 35, 830–849 (2019).
Google Scholar
Miao, Z. et al. A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma. Redox Biol. 73, 103220 (2024).
Google Scholar
Liu, X. et al. Engineered extracellular vesicle-delivered CRISPR/Cas9 for radiotherapy sensitization of glioblastoma. ACS Nano 17, 16432–16447 (2023).
Google Scholar
Liu, T. et al. Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance. Neuro Oncol. 24, 1113–1125 (2022).
Google Scholar
Lv, D. et al. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Mol. Cell 83, 4334–4351 (2023).
Google Scholar
Schonberg, D. L. et al. Preferential iron trafficking characterizes glioblastoma stem-like cells. Cancer Cell 28, 441–455 (2015).
Google Scholar
Yang, P. et al. G3BP1 is a tunable switch that triggers phase separation to assemble stress granules. Cell 181, 325–345 (2020).
Google Scholar
Richards, L. M. et al. Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity. Nat. Cancer 2, 157–173 (2021).
Google Scholar
Cui, Q., Liu, Z. & Bai, G. Friend or foe: the role of stress granule in neurodegenerative disease. Neuron 112, 2464–2485 (2024).
Google Scholar
Yin, J. et al. Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly. Sci. Transl. Med. 16, eadg5553 (2024).
Google Scholar
Neftel, C. et al. An integrative model of cellular states, plasticity, and genetics for glioblastoma. Cell 178, 835–849 (2019).
Google Scholar
Thedieck, K. et al. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell 154, 859–874 (2013).
Google Scholar
Khong, A. et al. The stress granule transcriptome reveals principles of mRNA accumulation in stress granules. Mol. Cell 68, 808–820 (2017).
Google Scholar
Cho, K. F. et al. Proximity labeling in mammalian cells with TurboID and split-TurboID. Nat. Protoc. 15, 3971–3999 (2020).
Google Scholar
Pan, C. R., Knutson, S. D., Huth, S. W. & MacMillan, D. W. C. microMap proximity labeling in living cells reveals stress granule disassembly mechanisms. Nat. Chem. Biol. 21, 490–500 (2025).
Google Scholar
Cui, Q. et al. Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules. Cell 186, 803–820 (2023).
Google Scholar
Gwon, Y. et al. Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Science 372, eabf6548 (2021).
Google Scholar
Najafov, A. et al. BRAF and AXL oncogenes drive RIPK3 expression loss in cancer. PLoS Biol. 16, e2005756 (2018).
Google Scholar
Koo, G. B. et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Res. 25, 707–725 (2015).
Google Scholar
Andre-Gregoire, G. et al. Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma. iScience 25, 105118 (2022).
Google Scholar
Morabito, S., Reese, F., Rahimzadeh, N., Miyoshi, E. & Swarup, V. hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell Rep. Methods 3, 100498 (2023).
Google Scholar
Freibaum, B. D. et al. Identification of small molecule inhibitors of G3BP-driven stress granule formation. J. Cell Biol. 223, e202308083 (2024).
Google Scholar
Stockwell, B. R. et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171, 273–285 (2017).
Google Scholar
Guo, J. et al. Mitochondria as multifaceted regulators of ferroptosis. Life Metab. 1, 134–148 (2022).
Google Scholar
Kakhlon, O. & Cabantchik, Z. I. The labile iron pool: characterization, measurement, and participation in cellular processes. Free Radic. Biol. Med. 33, 1037–1046 (2002).
Google Scholar
Caneque, T. et al. Activation of lysosomal iron triggers ferroptosis in cancer. Nature 642, 492–500 (2025).
Google Scholar
Freitas, F. P. et al. 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626, 401–410 (2024).
Google Scholar
Beatty, A. et al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat. Commun. 12, 2244 (2021).
Google Scholar
Buchan, J. R., Kolaitis, R. M., Taylor, J. P. & Parker, R. Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell 153, 1461–1474 (2013).
Google Scholar
Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W. & Kimmelman, A. C. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509, 105–109 (2014).
Google Scholar
Dowdle, W. E. et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16, 1069–1079 (2014).
Google Scholar
Ryan, L. & Rubinsztein, D. C. The autophagy of stress granules. FEBS Lett. 598, 59–72 (2024).
Google Scholar
Aledo, J. C. Methionine in proteins: the Cinderella of the proteinogenic amino acids. Protein Sci. 28, 1785–1796 (2019).
Google Scholar
Ge, Z. et al. Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation. Cell Rep. 42, 113417 (2023).
Google Scholar
Lin, S. et al. Redox-based reagents for chemoselective methionine bioconjugation. Science 355, 597–602 (2017).
Google Scholar
Sharifzad, F. et al. Glioblastoma cancer stem cell biology: potential theranostic targets. Drug Resist. Updat. 42, 35–45 (2019).
Google Scholar
Auffinger, B. et al. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ. 21, 1119–1131 (2014).
Google Scholar
Bao, S. et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756–760 (2006).
Google Scholar
Feng, H. et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 30, 3411–3423 (2020).
Google Scholar
Kim, J., Jo, Y., Cho, D. & Ryu, D. l-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans. Nat. Commun. 13, 6554 (2022).
Google Scholar
Yang, S. et al. Ferritinophagy mediated by oxidative stress-driven mitochondrial damage is involved in the polystyrene nanoparticles-induced ferroptosis of lung injury. ACS Nano 17, 24988–25004 (2023).
Google Scholar
Hou, W. et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12, 1425–1428 (2016).
Google Scholar
Liu, Q., Wang, F., Chen, Y., Cui, H. & Wu, H. A regulatory module comprising G3BP1–FBXL5–IRP2 axis determines sodium arsenite-induced ferroptosis. J. Hazard. Mater. 465, 133038 (2024).
Google Scholar
Wang, X. et al. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nat. Neurosci. 20, 661–673 (2017).
Google Scholar
Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).
Google Scholar
McGinnis, C. S., Murrow, L. M. & Gartner, Z. J. DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst. 8, 329–337 (2019).
Google Scholar
Wang, X. et al. Reciprocal signaling between glioblastoma stem cells and differentiated tumor cells promotes malignant progression. Cell Stem Cell 22, 514–528 (2018).
Google Scholar
Tian, Y. et al. Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1. Free Radic. Biol. Med. 189, 157–168 (2022).
Google Scholar
Abbasi, U., Abbina, S., Gill, A., Bhagat, V. & Kizhakkedathu, J. N. A facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens. Sci. Rep. 11, 6008 (2021).
Google Scholar
Zhang, S. et al. The GSA family in 2025: a broadened sharing platform for multi-omics and multimodal data. Genom. Proteom. Bioinform. 23, qzaf072 (2025).
Google Scholar
