Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
Google Scholar
Barton MK. Encouraging long-term outcomes reported in patients with stage I non-small cell lung cancer treated with stereotactic ablative radiotherapy. CA Cancer J Clin. 2017;67:349–50.
Google Scholar
Tan AC, Tan DSW. Targeted therapies for lung cancer patients with oncogenic driver molecular alterations. J Clin Oncol. 2022;40:611–25.
Google Scholar
Passaro A, Brahmer J, Antonia S, Mok T, Peters S. Managing resistance to immune checkpoint inhibitors in lung cancer: treatment and novel strategies. J Clin Oncol. 2022;40:598–610.
Google Scholar
Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553:446–54.
Google Scholar
Foster PA. Steroid metabolism in breast cancer. Minerva Endocrinol. 2008;33:27–37.
Google Scholar
Han Y, Zhuang Q, Sun B, Lv W, Wang S, Xiao Q, et al. Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. Nat Commun. 2021;12:449.
Google Scholar
Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Cabrera GM, et al. A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis. Cell. 2024;187:3784–3601.e22.
Google Scholar
Cantagrel V, Lefeber DJ, Ng BG, Guan ZQ, Silhavy JL, Bielas SL, et al. Is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 2010;142:203–17.
Google Scholar
Cui YN, Li J, Zhang PP, Yin DD, Wang ZY, Dai JL, et al. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma. J Exp Clin Canc Res. 2023;42:146.
Google Scholar
Huang Y, Zhang HL, Li ZL, Du T, Chen YH, Wang Y, et al. FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer. Nat Commun. 2021;12:2672.
Google Scholar
Liu YZ, Lan LH, Li YJ, Lu J, He LP, Deng Y, et al. N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth. Redox Biol. 2022;54:102366.
Google Scholar
Mai QC, Sheng DF, Chen CC, Gou Q, Chen M, Huang XT, et al. Steroid 5 alpha-reductase 3 (SRD5A3) promotes tumor growth and predicts poor survival of human hepatocellular carcinoma (HCC). Aging-Us. 2020;12:25395–411.
Google Scholar
Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, et al. A novel 5alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 2008;99:81–86.
Google Scholar
Liao K, Li J, He C, Peng J. N6-methyladenosine-modified SRD5A3, identified by IGF2BP3, sustains cisplatin resistance in bladder cancer. Hum Cell. 2024;38:30.
Google Scholar
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.
Google Scholar
Zhang YL, Shi JJ, Liu XG, Feng L, Gong ZH, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20:1181–92.
Google Scholar
Huang, D, Dong, X, Li, JZ, Chen, YD, Zhou, Y, Chen, QJ, et al. Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism. Med Oncol 2023;40:132.
Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18:280–96.
Google Scholar
Huang L, Zhong LF, Cheng RX, Chang LM, Qin MY, Liang HP, et al. Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma. Aging-Us. 2023;15:9676–94.
Google Scholar
Xing N, Du QY, Guo S, Xiang GL, Zhang Y, Meng XL, et al. Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy. Cell Death Discov. 2023;9:110.
Google Scholar
Liu PF, Kerins MJ, Tian W, Neupane D, Zhang DD, Ooi A. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. J Biol Chem. 2019;294:18131–49.
Google Scholar
Xu T, Zhang W, Gong S, Jiang B, Fu Z, Song F, et al. SPP1-SRD5A3 signaling axis regulated lymph node metastasis by activating Mucin type O glycan biosynthesis. Faseb J. 2025;39:e70494.
Google Scholar
Wang D, Li XH, Jiao DF, Cai Y, Qian LT, Shen YQ, et al. LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia. J Hematol Oncol. 2023;16:30.
Google Scholar
Yu J, Zhong BL, Zhao L, Hou Y, Ai NA, Lu JJ, et al. Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis. Drug Resist Update. 2023;70:100977.
Google Scholar
Zhang L, Xu YH, Cheng ZY, Zhao JL, Wang MX, Sun YC, et al. The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis. Cancer Lett. 2024;595:217000.
Google Scholar
Ma L, Chen C, Zhao C, Li T, Ma L, Jiang J, et al. Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer. Signal Transduct Target Ther. 2024;9:64.
Google Scholar
Zhang WJ, Sun Y, Bai L, Zhi LL, Yang Y, Zhao QZ, et al. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Investig. 2021;131:e152067.
Google Scholar
Wang ZJ, Shen N, Wang Z, Yu L, Yang S, Wang Y, et al. TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation. Cell Death Differ. 2024;31:53–64.
Google Scholar
Medina-Cano D, Ucuncu E, Nguyen LS, Nicouleau M, Lipecka J, Bizot JC, et al. High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect. Elife. 2018;7:e38309.
Google Scholar
Chen C, Wang L, Cui XF, Shang XY, Bai SH, Li L, et al. SCARA5 deficiency inhibits ferroptosis via regulating iron homeostasis and results in sorafenib resistance in hepatocellular carcinoma. Cell Signal. 2025;129:111656.
Google Scholar
Liu Y, Xiong R, Xiao T, Xiong L, Wu J, Li J, et al. SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain. BMC Cancer. 2022;22:1304.
Google Scholar
Qi WJ, Zhang SA. SCARA5 might be one potential marker for CC and promote ferroptosis by FTL. Am J Cancer Res. 2025;15:426–38.
Google Scholar
Liu J, Ren Z, Yang L, Zhu L, Li Y, Bie C, et al. The NSUN5-FTH1/FTL pathway mediates ferroptosis in bone marrow-derived mesenchymal stem cells. Cell Death Discov. 2022;8:99.
Google Scholar
Ke S, Wang C, Su Z, Lin S, Wu G. Integrated analysis reveals critical ferroptosis regulators and FTL contribute to cancer progression in hepatocellular carcinoma. Front Genet. 2022;13:897683.
Google Scholar
Shen Z, Liu T, Li Y, Lau J, Yang Z, Fan W, et al. Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors. Acs Nano. 2018;12:11355–65.
Google Scholar
