Cortesi A, Gandolfi F, Arco F, Di Chiaro P, Valli E, Polletti S, et al. Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer. Sci Adv. 2024;10:eadk5386.
Sha H, Tong F, Ni J, Sun Y, Zhu Y, Qi L, et al. First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial. Signal Transduct Target Ther. 2024;9:143.
Kirtonia A, Pandey AK, Ramachandran B, Mishra DP, Dawson DW, Sethi G, et al. Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade. Cell Mol Life Sci. 2022;79:362.
Pandya G, Kirtonia A, Sethi G, Pandey AK, Garg M. The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential. Biochim Biophys Acta Rev Cancer. 2020;1874:188423.
Zhou P, Du X, Jia W, Feng K, Zhang Y. Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer. Signal Transduct Target Ther. 2024;9:151.
Chien W, Sudo M, Ding LW, Sun QY, Wuensche P, Lee KL, et al. Functional genome-wide screening identifies targets and pathways sensitizing pancreatic cancer cells to Dasatinib. J Cancer. 2018;9:4762–73.
Chien W, Ding LW, Sun QY, Torres-Fernandez LA, Tan SZ, Xiao J, et al. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget. 2014;5:4881–94.
Pandya G, Kirtonia A, Singh A, Goel A, Mohan CD, Rangappa KS, et al. A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma. Semin Cancer Biol. 2022;86:682–92.
Lencioni G, Gregori A, Toledo B, Rebelo R, Immordino B, Amrutkar M, et al. Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems. Semin Cancer Biol. 2024;106-7:217–33.
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921.
Palazzo AF, Koonin EV. Functional Long Non-coding RNAs Evolve from Junk Transcripts. Cell. 2020;183:1151–61.
Yadav B, Pal S, Rubstov Y, Goel A, Garg M, Pavlyukov M, et al. LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics. Mol Ther Nucleic Acids. 2021;24:728–42.
Kanojia D, Kirtonia A, Srujana NSV, Jeevanandan SP, Shyamsunder P, Sampath SS, et al. Transcriptome analysis identifies TODL as a novel lncRNA associated with proliferation, differentiation, and tumorigenesis in liposarcoma through FOXM1. Pharm Res. 2022;185:106462.
Shabna A, Bindhya S, Sidhanth C, Garg M, Ganesan TS. Long non-coding RNAs: Fundamental regulators and emerging targets of cancer stem cells. Biochim Biophys Acta Rev Cancer. 2023;1878:188899.
Huang ZH, Du YP, Wen JT, Lu BF, Zhao Y. snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology. Cell Death Discov. 2022;8:259.
Xiao H, Feng X, Liu M, Gong H, Zhou X. SnoRNA and lncSNHG: Advances of nucleolar small RNA host gene transcripts in anti-tumor immunity. Front Immunol. 2023;14:1143980.
Williams GT, Farzaneh F. Are snoRNAs and snoRNA host genes new players in cancer?. Nat Rev Cancer. 2012;12:84–8.
Xiao S, Zha Y, Zhu H. miR-621 may suppress cell proliferation via targeting lncRNA SNHG10 in acute myeloid leukemia. Cancer Manag Res. 2021;13:2117–23.
Yuan X, Yang T, Xu Y, Ou S, Shi P, Cao M, et al. SNHG10 promotes cell proliferation and migration in gastric cancer by targeting miR-495-3p/CTNNB1 axis. Digest Dis Sci. 2021;66:2627–36.
Jin L, Huang S, Guan C, Chang S. ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis. Cancer Cell Int. 2020;20:589.
Zhang H, Fang Z, Guo Y, Wang D. Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690. Bioengineered. 2021;12:6010–20.
He P, Xu Y, Wang Z. LncRNA SNHG10 increases the methylation of miR-218 gene to promote glucose uptake and cell proliferation in osteosarcoma. J Orthop Surg Res. 2020;15:353.
Zhu S, Liu Y, Wang X, Wang J, Xi G. lncRNA SNHG10 promotes the proliferation and invasion of Osteosarcoma via Wnt/beta-Catenin signaling. Mol Ther Nucleic acids. 2020;22:957–70.
Cao H, Wang D, Sun P, Chen L, Feng Y, Gao R. Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis. Aging. 2021;13:23096–107.
Lan T, Yuan K, Yan X, Xu L, Liao H, Hao X, et al. LncRNA SNHG10 Facilitates Hepatocarcinogenesis and Metastasis by Modulating Its Homolog SCARNA13 via a Positive Feedback Loop. Cancer Res. 2019;79:3220–34.
Liang M, Wang L, Cao C, Song S, Wu F. LncRNA SNHG10 is downregulated in non-small cell lung cancer and predicts poor survival. BMC Pulm Med. 2020;20:273.
Zhang Z, Nong L, Chen ML, Gu XL, Zhao WW, Liu MH, et al. Long Noncoding RNA SNHG10 Sponges miR-543 to upregulate tumor suppressive SIRT1 in nonsmall cell lung cancer. Cancer Biother Radiopharm. 2020;35:771–5.
Lv W, Jia Y, Wang J, Duan Y, Wang X, Liu T, et al. Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial-mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p. Cell Death Discov. 2022;8:60.
Chen K, Wang Q, Liu X, Wang F, Ma Y, Zhang S, et al. Single Cell RNA-Seq identifies immune-related prognostic model and key signature-SPP1 in pancreatic ductal adenocarcinoma. Genes (Basel). 2022;29:1760.
Zhu J, Jian Z, Liu F, Le L. The emerging landscape of small nucleolar RNA host gene 10 in cancer mechanistic insights and clinical relevance. Cell Signal. 2025;127:111590.
Lee JS, Mendell JT. Antisense-mediated transcript knockdown triggers premature transcription termination. Mol Cell. 2020;77:1044–54 e3.
Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther. 2020;5:28.
Lambert AW, Pattabiraman DR, Weinberg RA. Emerging biological principles of metastasis. Cell. 2017;168:670–91.
Chen X, Xu X, Pan B, Zeng K, Xu M, Liu X, et al. miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer. Aging. 2018;10:3421–37.
Chen JQ, Tao YP, Hong YG, Li HF, Huang ZP, Xu XF, et al. M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling. Cell Cycle. 2021;20:2507–18.
Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol. 1991;163:111–6.
Collisson EA, Bailey P, Chang DK, Biankin AV. Molecular subtypes of pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2019;16:207–20.
Luo J. KRAS mutation in pancreatic cancer. Semin Oncol. 2021;48:10–8.
Qin T, Xiao Y, Qian W, Wang X, Gong M, Wang Q, et al. HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis. Cell Death Dis. 2022;13:387.
Xu Z, Pang TCY, Liu AC, Pothula SP, Mekapogu AR, Perera CJ, et al. Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis. Br J Cancer. 2020;122:1486–95.
De Santis MC, Bockorny B, Hirsch E, Cappello P, Martini M. Exploiting pancreatic cancer metabolism: challenges and opportunities. Trends Mol Med. 2024;30:592–604.
Chen C, Zhao S, Zhao X, Cao L, Karnad A, Kumar AP, et al. Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R-dependent upregulation of CD44 expression and isoform switching. Cell Death Dis. 2022;13:682.
Samulitis BK, Pond KW, Pond E, Cress AE, Patel H, Wisner L, et al. Gemcitabine-resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors. Cancer Biol Ther. 2015;16:43–51.
Kirtonia A, Pandya G, Singh A, Kumari R, Singh B, Kapoor S, et al. Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/KRAS/LAMC2/ERK/AKT signaling cascade. Life Sci. 2025;362:123364.
Statello L, Guo CJ, Chen LL, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22:96–118.
Tashiro E, Tsuchiya A, Imoto M. Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci. 2007;98:629–35.
Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 2023;24:430–47.
Liao W, Deng X, Chen G, Yang J, Li Y, Li L, et al. MiR-150-5p contributes to unexplained recurrent spontaneous abortion by targeting VEGFA and downregulating the PI3K/AKT/mTOR signaling pathway. J Assist Reprod Genet. 2024;41:63–77.
Qin Y, Zhang B, Ge BJ. MicroRNA-150-5p inhibits proliferation and invasion of osteosarcoma cells by down-regulating VEGFA. Eur Rev Med Pharmacol Sci. 2020;24:9265–73.
Kanojia D, Garg M, Saini S, Agarwal S, Parashar D, Jagadish N, et al. Sperm associated antigen 9 plays an important role in bladder transitional cell carcinoma. PloS One. 2013;8:e81348.
Deswal B, Bagchi U, Santra MK, Garg M, Kapoor S. Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancer. BMC Cancer. 2024;24:1129.
Kanojia D, Garg M, Martinez J, TA M, Luty SB, Doan NB, et al. Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets. J Hematol Oncol. 2017;10:173.
Shahid M, Jain P, De A, Srivastava V, Singh A, Garg M, et al. Synthesis, characterization, crystal structure, and molecular docking of o-vanillin and l-valine-derived molecules: a DFT study and antiproliferative activity against the PANC-1 cancer cell line. New J. Chem. 2025;49:721–37.
Garg M, Kanojia D, Mayakonda A, Ganesan TS, Sadhanandhan B, Suresh S, et al. Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin. Sci Rep. 2017;7:9749.
Gala K, Jain M, Shah P, Pandey A, Garg M, Khattar E. Role of p53 transcription factor in determining the efficacy of telomerase inhibitors in cancer treatment. Life Sci. 2024;339:122416.
Hayano T, Garg M, Yin D, Sudo M, Kawamata N, Shi S, et al. SOX7 is down-regulated in lung cancer. J Exp Clin Cancer Res. 2013;32:17.
Sneha S, Nagare RP, Sidhanth C, Krishnapriya S, Garg M, Ramachandran B, et al. The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary. Cell Oncol. 2020;43:601–16.
Garg M, Okamoto R, Nagata Y, Kanojia D, Venkatesan S, Anand MT, et al. Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft. J Clin Endocrinol Metab. 2015;100:725–35.
Arora S, Tanwar J, Sharma N, Saurav S, Motiani RK. Orai3 regulates pancreatic cancer metastasis by encoding a functional store operated calcium entry channel. Cancers (Basel). 2021;13:5937.
Garg M, Kanojia D, Suri S, Suri A. Small interfering RNA-mediated down-regulation of SPAG9 inhibits cervical tumor growth. Cancer. 2009;115:5688–99.
Littlejohn JE, Cao X, Miller SD, Ozvaran MK, Jupiter D, Zhang L, et al. Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts. Int J Cancer. 2008;123:202–8.
Gutschner T, Hammerle M, Eissmann M, Hsu J, Kim Y, Hung G, et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013;73:1180–9.
Li M, Ding X, Zhang Y, Li X, Zhou H, Yang L, et al. Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/beta-catenin pathway in head and neck squamous cell carcinomas. Cell Death Dis. 2020;11:672.
Li Y, Gan Y, Liu J, Li J, Zhou Z, Tian R, et al. Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. Signal Transduct Target Ther. 2022;7:87.

