Razumilava, N. & Gores, G. J. Cholangiocarcinoma. Lancet 383(9935), 2168–2179 (2014).
Google Scholar
Rizvi, S., Khan, S. A., Hallemeier, C. L., Kelley, R. K. & Gores, G. J. Cholangiocarcinoma—Evolving concepts and therapeutic strategies. Nat. Rev. Clin. Oncol. 15(2), 95–111 (2018).
Google Scholar
Morizane, C. et al. Randomized phase II study of gemcitabine plus S-1 versus S-1 in advanced biliary tract cancer: A Japan clinical oncology group trial (JCOG 0805). Cancer Sci. 104(9), 1211–1216 (2013).
Google Scholar
Sakamoto, Y. et al. Proposal of a new staging system for intrahepatic cholangiocarcinoma: Analysis of surgical patients from a nationwide survey of the liver cancer study group of Japan. Cancer 122(1), 61–70 (2016).
Google Scholar
Hernandez, J. et al. An aggressive approach to extrahepatic cholangiocarcinomas is warranted: Margin status does not impact survival after resection. Ann. Surg. Oncol. 15(3), 807–814 (2008).
Google Scholar
Gortan Cappellari, G. et al. Sarcopenic obesity: What about in the cancer setting?. Nutrition 98, 111624 (2022).
Google Scholar
Cruz-Jentoft, A. J. & Sayer, A. A. Sarcopenia. Lancet 393(10191), 2636–2646 (2019).
Google Scholar
Fujiwara, N. et al. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. J. Hepatol. 63(1), 131–140 (2015).
Google Scholar
Han, J. S. et al. Association of body composition with long-term survival in non-metastatic rectal cancer patients. Cancer Res. Treat. 52(2), 563–572 (2020).
Google Scholar
Tan, B. H., Birdsell, L. A., Martin, L., Baracos, V. E. & Fearon, K. C. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin. Cancer Res. 15(22), 6973–6979 (2009).
Google Scholar
Okamura, A. et al. Clinical impact of abdominal fat distribution on prognosis after esophagectomy for esophageal squamous cell carcinoma. Ann. Surg. Oncol. 23(4), 1387–1394 (2016).
Google Scholar
Pecorelli, N. et al. Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery. Br. J. Surg. 103(4), 434–442 (2016).
Google Scholar
Rickles, A. S. et al. Visceral obesity and colorectal cancer: are we missing the boat with BMI?. J. Gastrointest. Surg. 17(1), 133–143 (2013).
Google Scholar
Antoun, S. et al. High subcutaneous adipose tissue predicts the prognosis in metastatic castration-resistant prostate cancer patients in post chemotherapy setting. Eur. J. Cancer 51(17), 2570–2577 (2015).
Google Scholar
Porter, S. A. et al. Abdominal subcutaneous adipose tissue: A protective fat depot?. Diabetes Care 32(6), 1068–1075 (2009).
Google Scholar
Zopfs, D. et al. Single-slice CT measurements allow for accurate assessment of sarcopenia and body composition. Eur. Radiol. 30(3), 1701–1708 (2020).
Google Scholar
Ebadi, M. & Mazurak, V. C. Evidence and mechanisms of fat depletion in cancer. Nutrients 6(11), 5280–5297 (2014).
Google Scholar
Shachar, S. S., Williams, G. R., Muss, H. B. & Nishijima, T. F. Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review. Eur. J. Cancer 57, 58–67 (2016).
Google Scholar
Lurje, I. et al. The prognostic impact of preoperative body composition in perihilar and intrahepatic cholangiocarcinoma. Hepatol Commun. 6(9), 2400–2417 (2022).
Google Scholar
Tamura, S. et al. The prognostic impact of skeletal muscle status and bone mineral density for resected distal cholangiocarcinoma. Clin. Nutr. 40(5), 3552–3558 (2021).
Google Scholar
Ebadi, M. et al. Subcutaneous adiposity is an independent predictor of mortality in cancer patients. Br. J. Cancer 117(1), 148–155 (2017).
Google Scholar
Song, S. E. et al. Machine learning with multiparametric breast MRI for prediction of Ki-67 and histologic grade in early-stage luminal breast cancer. Eur. Radiol. 32(2), 853–863 (2022).
Google Scholar
Correa-de-Araujo, R. et al. Myosteatosis in the context of skeletal muscle function deficit: An interdisciplinary workshop at the national institute on aging. Front. Physiol. 11, 963 (2020).
Google Scholar
Camp, R. L., Dolled-Filhart, M. & Rimm, D. L. X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin. Cancer Res. 10(21), 7252–7259 (2004).
Google Scholar
Liu, J., Yu, X., Huang, X., Lai, Q. & Chen, J. Associations of muscle and adipose tissue parameters with long-term outcomes in middle and low rectal cancer: A retrospective cohort study. Cancer Imaging 23(1), 5 (2023).
Google Scholar
Li, H. et al. Combination of albumin-globulin score and skeletal muscle index predicts long-term outcomes of intrahepatic cholangiocarcinoma patients after curative resection. Clin. Nutr. 40(6), 3891–3900 (2021).
Google Scholar
Brown, J. C. et al. The association of abdominal adiposity with mortality in patients with stage I-III colorectal cancer. J. Natl. Cancer Inst. 112(4), 377–383 (2020).
Google Scholar
Lee, E. C., Park, S. J., Lee, S. D., Han, S. S. & Kim, S. H. Effects of sarcopenia on prognosis after resection of gallbladder cancer. J. Gastrointest. Surg. 24(5), 1082–1091 (2020).
Google Scholar
Tamandl, D. et al. Markers of sarcopenia quantified by computed tomography predict adverse long-term outcome in patients with resected oesophageal or gastro-oesophageal junction cancer. Eur. Radiol. 26(5), 1359–1367 (2016).
Google Scholar
Zhou, J. et al. Sarcopenic obesity by the ESPEN/EASO criteria for predicting mortality in advanced non-small cell lung cancer. Clin. Nutr. 42(6), 817–824 (2023).
Google Scholar
Li, F. et al. Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue. Cytokine Growth Factor Rev. 33, 73–82 (2017).
Google Scholar
Pedersen, B. K. & Febbraio, M. A. Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 8(8), 457–465 (2012).
Google Scholar
Hojman, P. et al. Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth. Am. J. Physiol. Endocrinol. Metab. 301(3), E504–E510 (2011).
Google Scholar
Aoi, W. et al. A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. Gut 62(6), 882–889 (2013).
Google Scholar
Snyder, P. J. et al. Lessons from the testosterone trials. Endocr. Rev. 39(3), 369–386 (2018).
Google Scholar
Cramer, J. T. et al. Impacts of high-protein oral nutritional supplements among malnourished men and women with sarcopenia: A multicenter, randomized, double-blinded, controlled trial. J. Am. Med. Dir. Assoc. 17(11), 1044–1055 (2016).
Google Scholar
Cruz-Jentoft, A. J. Beta-hydroxy-beta-methyl butyrate (HMB): From experimental data to clinical evidence in sarcopenia. Curr. Protein Pept. Sci. 19(7), 668–672 (2018).
Google Scholar
Strulov Shachar, S. & Williams, G. R. The obesity paradox in cancer-moving beyond BMI. Cancer Epidemiol. Biomarkers Prev. 26(1), 13–16 (2017).
Google Scholar
Steffens, S. et al. Does obesity influence the prognosis of metastatic renal cell carcinoma in patients treated with vascular endothelial growth factor-targeted therapy?. Oncologist 16(11), 1565–1571 (2011).
Google Scholar
Tritos, N. A. & Mantzoros, C. S. Leptin: Its role in obesity and beyond. Diabetologia 40(12), 1371–1379 (1997).
Google Scholar
Tran, T. T., Yamamoto, Y., Gesta, S. & Kahn, C. R. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 7(5), 410–420 (2008).
Google Scholar
Li, C., Qu, L., Farragher, C., Vella, A. & Zhou, B. MicroRNA regulated macrophage activation in obesity. J. Transl. Intern. Med. 7(2), 46–52 (2019).
Google Scholar
Arano, T. et al. Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients. Int. J. Cancer 129(9), 2226–2235 (2011).
Google Scholar
Girard, J. & Lafontan, M. Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism. Diabetes Metab. 34(5), 439–445 (2008).
Google Scholar

