Yang, W. S. & Stockwell, B. R. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem. Biol. 15, 234–245 (2008).
Google ScholarÂ
Seiler, A. et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, 237–248 (2008).
Google ScholarÂ
Decollogny, M. & Rottenberg, S. Persisting cancer cells are different from bacterial persisters. Trends Cancer 10, 393–406 (2024).
Google ScholarÂ
Mai, T. et al. Salinomycin kills cancer stem cells by sequestering iron in lysosomes. Nat. Chem. 9, 1025–1033 (2017).
Google ScholarÂ
Viswanathan, V. S. et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547, 453–457 (2017).
Google ScholarÂ
Cañeque, T. et al. Activation of lysosomal iron triggers ferroptosis in cancer. Nature 642, 492–500 (2025).
Google ScholarÂ
Wu, K. et al. Targeting FSP1 triggers ferroptosis in lung cancer. Nature 649, 487–495 (2026).
Google ScholarÂ
Rizzollo, F. et al. BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states. Nat. Metab. 7, 1851–1870 (2025).
Google ScholarÂ
Higuchi, M. et al. FSP1 and histone deacetylase suppress cancer persister cell ferroptosis. Sci Adv. 12, eaea8771 (2026).
Google ScholarÂ
Müller, S. et al. CD44 regulates epigenetic plasticity by mediating iron endocytosis. Nat. Chem. 12, 929–938 (2020).
Google ScholarÂ
Rizzollo, F. et al. The lysosome as master regulator of iron metabolism. Trends Biochem. Sci. 46, 960–975 (2021).
Google ScholarÂ
Orman, M. A. et al. Beyond metabolic dormancy: metabolic rewiring in bacterial persistence. Nat. Commun. 17, 3536 (2026).
Google ScholarÂ
Devireddy, L. R. et al. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 141, 1006–1017 (2010).
Google ScholarÂ
Chi, Y. et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369, 276–282 (2020).
Google ScholarÂ
Vaishampayan, A. & Grohmann, E. Antimicrobials functioning through ROS-mediated mechanisms: Current Insights. Microorganisms 10, 61 (2021).
Google ScholarÂ

