Pimenta JVC, Dos Santos LB, Almeida MR, Augusti R, de Macedo AN. Geographic origin characterization of Brazilian green coffee beans via untargeted metabolomics. Food Chem. 2025;464:141683.
Google Scholar
Clark I, Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2017;31:70–8.
Google Scholar
Peleli M, Fredholm BB, Sobrevia L, Carlstrom M. Pharmacological targeting of adenosine receptor signaling. Mol Asp Med. 2017;55:4–8.
Google Scholar
Wu L, Meng J, Shen Q, Zhang Y, Pan S, Chen Z, et al. Caffeine inhibits hypothalamic A(1)R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nat Commun. 2017;8:15904.
Google Scholar
Zhang YH, Li YF, Wang Y, Tan L, Cao ZQ, Xie C, et al. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun. 2020;11:1473.
Google Scholar
Huang W, Cane MC, Mukherjee R, Szatmary P, Zhang X, Elliott V, et al. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release. Gut. 2017;66:301–13.
Google Scholar
Borges-Martins VPP, Ferreira DDP, Souto AC, Oliveira Neto JG, Pereira-Figueiredo D, da Costa Calaza K, et al. Caffeine regulates GABA transport via A(1)R blockade and cAMP signaling. Neurochem Int. 2019;131:104550.
Google Scholar
Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Niksic M, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023–75.
Google Scholar
Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, et al. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun. 2018;9:1646.
Google Scholar
Krul MF, Elferink MAG, Kok NFM, Dekker E, Lansdorp-Vogelaar I, Meijer GA, et al. Initial impact of national CRC screening on incidence and advanced colorectal cancer. Clin Gastroenterol Hepatol. 2023;21:797–807.e793.
Google Scholar
Issaka RB, Chan AT, Gupta S. AGA clinical practice update on risk stratification for colorectal cancer screening and post-polypectomy surveillance: expert review. Gastroenterology. 2023;165:1280–91.
Google Scholar
O’Keefe SJ. Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. 2016;13:691–706.
Google Scholar
Stoffel EM, Murphy CC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology. 2020;158:341–53.
Google Scholar
Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr. 2017;37:131–56.
Google Scholar
Mackintosh C, Yuan C, Ou FS, Zhang S, Niedzwiecki D, Chang IW, et al. Association of coffee intake with survival in patients with advanced or metastatic colorectal cancer. JAMA Oncol. 2020;6:1713–21.
Google Scholar
Oyelere, Kok DE AM, Bos D, Gunter MJ, Ferrari P, Keski-Rahkonen P, et al. Coffee consumption is associated with a reduced risk of colorectal cancer recurrence and all-cause mortality. Int J Cancer. 2024;154:2054–63.
Google Scholar
Guercio BJ, Sato K, Niedzwiecki D, Ye X, Saltz LB, Mayer RJ, et al. Coffee intake, recurrence, and mortality in stage III colon cancer: results from CALGB 89803 (Alliance). J Clin Oncol. 2015;33:3598–607.
Google Scholar
Hu Y, Ding M, Yuan C, Wu K, Smith-Warner SA, Hu FB, et al. Association between coffee intake after diagnosis of colorectal cancer and reduced mortality. Gastroenterology. 2018;154:916–26.e919.
Google Scholar
Parang B, Barrett CW, Williams CS. AOM/DSS model of colitis-associated cancer. Methods Mol Biol. 2016;1422:297–307.
Google Scholar
De Robertis M, Massi E, Poeta ML, Carotti S, Morini S, Cecchetelli L, et al. The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog. 2011;10:9.
Google Scholar
Mei HF, Poonit N, Zhang YC, Ye CY, Cai HL, Yu CY, et al. Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure. Mol Cell Biochem. 2018;446:161–70.
Google Scholar
Li X, Chen L, Zhou H, Wang J, Zhao C, Pang X. PFOA regulate adenosine receptors and downstream concentration-response cAMP-PKA pathway revealed by integrated omics and molecular dynamics analyses. Sci Total Environ. 2022;803:149910.
Google Scholar
Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, et al. ADORA1 inhibition promotes tumor immune evasion by regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020;37:324–39.e328.
Google Scholar
Hilger D, Masureel M, Kobilka BK. Structure and dynamics of GPCR signaling complexes. Nat Struct Mol Biol. 2018;25:4–12.
Google Scholar
Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, et al. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013;27:1223–32.
Google Scholar
Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes Dev. 2016;30:1–17.
Google Scholar
Ohgushi M, Minaguchi M, Sasai Y. Rho-signaling-directed YAP/TAZ activity underlies the long-term survival and expansion of human embryonic stem cells. Cell Stem Cell. 2015;17:448–61.
Google Scholar
Desale SE, Chidambaram H, Chinnathambi S. G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-beta in Alzheimer’s disease. Mol Biomed. 2021;2:17.
Google Scholar
van Dam RM, Hu FB, Willett WC. Coffee, Caffeine, and Health. N Engl J Med. 2020;383:369–78.
Google Scholar
Zhang P, Bannon NM, Ilin V, Volgushev M, Chistiakova M. Adenosine effects on inhibitory synaptic transmission and excitation-inhibition balance in the rat neocortex. J Physiol. 2015;593:825–41.
Google Scholar
Lopez CD, Bekisz JM, Corciulo C, Mediero A, Coelho PG, Witek L, et al. Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing. Adv Drug Deliv Rev. 2019;146:240–7.
Google Scholar
Rabbani P, Ramkhelawon B, Cronstein BN. Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems. Ageing Res Rev. 2025;106:102695.
Google Scholar
Boison D, Yegutkin GG. Adenosine metabolism: emerging concepts for cancer therapy. Cancer Cell. 2019;36:582–96.
Google Scholar
Bai Y, Zhang X, Zheng J, Liu Z, Yang Z, Zhang X. Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist. J Exp Clin Cancer Res. 2022;41:302.
Google Scholar
Wang L, Londono LM, Cowell J, Saatci O, Aras M, Ersan PG, et al. Targeting adenosine with adenosine deaminase 2 to inhibit growth of solid tumors. Cancer Res. 2021;81:3319–32.
Google Scholar
Zhang C, Wang K, Wang H. Adenosine in cancer immunotherapy: taking off on a new plane. Biochim Biophys Acta Rev Cancer. 2023;1878:189005.
Google Scholar
Hong AW, Meng Z, Guan KL. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016;13:324–37.
Google Scholar
Cheung P, Xiol J, Dill MT, Yuan WC, Panero R, Roper J, et al. Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer. Cell Stem Cell. 2020;27:590–604.e599.
Google Scholar
Ma S, Meng Z, Chen R, Guan KL. The Hippo pathway: biology and pathophysiology. Annu Rev Biochem. 2019;88:577–604.
Google Scholar
Wu Z, Guan KL. Hippo signaling in embryogenesis and development. Trends Biochem Sci. 2021;46:51–63.
Google Scholar
Guo P, Wan S, Guan KL. The Hippo pathway: organ size control and beyond. Pharm Rev. 2025;77:100031.
Google Scholar
Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, et al. The Hippo pathway kinases LATS1/2 suppress cancer immunity. Cell. 2016;167:1525–39.e1517.
Google Scholar
Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. Nature. 2015;526:715–8.
Google Scholar
Baroja I, Kyriakidis NC, Halder G, Moya IM. Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer. Nat Commun. 2024;15:2700.
Google Scholar
Yong J, Li Y, Lin S, Wang Z, Xu Y. Inhibitors targeting YAP in gastric cancer: current status and future perspectives. Drug Des Devel Ther. 2021;15:2445–56.
Google Scholar
Sato K, Faraji F, Cervantes-Villagrana RD, Wu X, Koshizuka K, Ishikawa T, et al. Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma. Cancer Lett. 2025;612:217467.
Google Scholar
Liu S, Anderson PJ, Rajagopal S, Lefkowitz RJ, Rockman HA. G protein-coupled receptors: a century of research and discovery. Circ Res. 2024;135:174–97.
Google Scholar
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, et al. Pharmacogenomics of GPCR drug targets. Cell. 2018;172:41.–54.e19.
Google Scholar
Eiger DS, Pham U, Gardner J, Hicks C, Rajagopal S. GPCR systems pharmacology: a different perspective on the development of biased therapeutics. Am J Physiol Cell Physiol. 2022;322:C887–C895.
Google Scholar
Fasciani I, Carli M, Petragnano F, Colaianni F, Aloisi G, Maggio R et al: GPCRs in intracellular compartments: new targets for drug discovery. Biomolecules 2022, 12.
Downey ML, Peralta-Yahya P. Technologies for the discovery of G protein-coupled receptor-targeting biologics. Curr Opin Biotechnol. 2024;87:103138.
Google Scholar
Liu Y, An S, Ward R, Yang Y, Guo XX, Li W, et al. G protein-coupled receptors as promising cancer targets. Cancer Lett. 2016;376:226–39.
Google Scholar
Lam T, Mastos C, Sloan EK, Halls ML. Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer. Pharm Ther. 2023;241:108331.
Google Scholar
Wei Y, Hui VLZ, Chen Y, Han R, Han X, Guo Y. YAP/TAZ: Molecular pathway and disease therapy. MedComm (2020). 2023;4:e340.
Google Scholar
Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, et al. Regulation of the Hippo-YAP Pathway by G-protein-coupled receptor signaling. Cell. 2024;187:1563–4.
Google Scholar
Mouillet-Richard S, Cazelles A, Sroussi M, Gallois C, Taieb J, Laurent-Puig P. Clinical challenges of consensus molecular subtype CMS4 colon cancer in the era of precision medicine. Clin Cancer Res. 2024;30:2351–8.
Google Scholar
Mouillet-Richard S, Laurent-Puig P: YAP/TAZ Signalling in Colorectal Cancer: Lessons from Consensus Molecular Subtypes. Cancers. 2020, 12.
Cai J, Maitra A, Anders RA, Taketo MM, Pan D. beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev. 2015;29:1493–506.
Google Scholar
Ou C, Sun Z, Li S, Li G, Li X, Ma J. Dual roles of yes-associated protein (YAP) in colorectal cancer. Oncotarget. 2017;8:75727–41.
Google Scholar
Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature. 2013;493:106–10.
Google Scholar
Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579–91.
Google Scholar
Fu V, Guan KL. Tales from the cryptkeeper: new roles for Lats1/2 in Wnt-driven homeostasis. Cell Stem Cell. 2020;26:612–4.
Google Scholar
Li Q, Sun Y, Jarugumilli GK, Liu S, Dang K, Cotton JL, et al. Lats1/2 sustain intestinal stem cells and Wnt activation through TEAD-dependent and independent transcription. Cell Stem Cell. 2020;26:675–92.e678.
Google Scholar
Li Z, Su P, Yu M, Zhang X, Xu Y, Jia T, et al. YAP represses the TEAD-NF-kappaB complex and inhibits the growth of clear cell renal cell carcinoma. Sci Signal. 2024;17:eadk0231.
Google Scholar
Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98–W102.
Google Scholar
Gyorffy B. Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innovation. 2024;5:100625.
Google Scholar
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–50.
Google Scholar
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34:267–73.
Google Scholar
Lyu F, Han F, Ge C, Mao W, Chen L, Hu H, et al. OmicStudio: a composable bioinformatics cloud platform with real-time feedback that can generate high-quality graphs for publication. Imeta. 2023;2:e85.
Google Scholar
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10:1523.
Google Scholar
Tang D, Chen M, Huang X, Zhang G, Zeng L, Zhang G, et al. SRplot: a free online platform for data visualization and graphing. PLoS One. 2023;18:e0294236.
Google Scholar

