A Sellas immunotherapy study, long delayed, will end in failure

Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54.

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Sellas Life Sciences Group is a blowup waiting to happen. My prediction: Sellas’ experimental immunotherapy will fail to prolong survival compared to standard treatment for patients with acute myeloid leukemia in a second remission.

I’m confident in my prediction the company’s Phase 3 REGAL study will have a negative outcome; I just don’t know when it will happen. The conclusion of the event-driven study has already been delayed by nearly a year — raising significant doubts about the efficacy of the Sellas treatment, called galinpepimut-S, or GPS.

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