Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. https://doi.org/10.3322/caac.21660.
Google ScholarÂ
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020;396:635–48. https://doi.org/10.1016/S0140-6736(20)31288-5.
Google ScholarÂ
LAUREN P. The two main histological types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49. https://doi.org/10.1111/apm.1965.64.1.31.
Google ScholarÂ
Schirren R, Novotny A, Oesterlin C, Slotta-Huspenina J, Friess H, Reim D. Significance of Lauren classification in patients undergoing neoadjuvant/perioperative chemotherapy for locally advanced gastric or gastroesophageal junction cancers-analysis from a large single center cohort in Germany. Cancers. 2021;13:290. https://doi.org/10.3390/cancers13020290.
Google ScholarÂ
Wang L, Sun M, Li J, Wan L, Tan Y, Tian S, et al. Intestinal subtype as a biomarker of response to neoadjuvant immunochemotherapy in locally advanced gastric adenocarcinoma: insights from a prospective phase II trial. Clin Cancer Res. 2025;31:74–86. https://doi.org/10.1158/1078-0432.CCR-24-2436.
Google ScholarÂ
Wang K, Yu Y, Zhao J, Meng Q, Xu C, Ren J, et al. A retrospective analysis of the Lauren classification in the choice of XELOX or SOX as an adjuvant chemotherapy for gastric cancer. Curr Gene Ther. 2024;24:147–58. https://doi.org/10.2174/0115665232247694230921060213.
Google ScholarÂ
Liu L, Wang ZW, Ji J, Zhang JN, Yan M, Zhang J, et al. A cohort study and meta-analysis between histopathological classification and prognosis of gastric carcinoma. Anticancer Agents Med Chem. 2013;13:227–34. https://doi.org/10.2174/1871520611313020007.
Google ScholarÂ
Lin X, Zhao Y, Song WM, Zhang B. Molecular classification and prediction in gastric cancer. Comput Struct Biotechnol J. 2015;13:448–58. https://doi.org/10.1016/j.csbj.2015.08.001.
Google ScholarÂ
Sainero-Alcolado L, Liaño-Pons J, Ruiz-Pérez MV, Arsenian-Henriksson M. Targeting mitochondrial metabolism for precision medicine in cancer. Cell Death Differ. 2022;29:1304–17. https://doi.org/10.1038/s41418-022-01022-y.
Google ScholarÂ
Zhang L, Joshi AK, Smith S. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. J Biol Chem. 2003;278:40067–74. https://doi.org/10.1074/jbc.M306121200.
Google ScholarÂ
Wedan RJ, Longenecker JZ, Nowinski SM. Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism. Cell Metab. 2024;36:36–47. https://doi.org/10.1016/j.cmet.2023.11.017.
Google ScholarÂ
Di Gregorio J, Petricca S, Iorio R, Toniato E, Flati V. Mitochondrial and metabolic alterations in cancer cells. Eur J Cell Biol. 2022;101:151225. https://doi.org/10.1016/j.ejcb.2022.151225.
Google ScholarÂ
Quan J, Bode AM, Luo X. ACSL family: the regulatory mechanisms and therapeutic implications in cancer. Eur J Pharm. 2021;909:174397. https://doi.org/10.1016/j.ejphar.2021.174397.
Google ScholarÂ
Agrawal A, Balcı H, Hanspers K, Coort SL, Martens M, Slenter DN, et al. WikiPathways 2024: next-generation pathway database. Nucleic Acids Res. 2024;52:D679–89. https://doi.org/10.1093/nar/gkad960.
Google ScholarÂ
Gaud C, C Sousa B, Nguyen A, Fedorova M, Ni Z, O’Donnell VB, et al. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Res. 2021;10:4. https://doi.org/10.12688/f1000research.28022.2.
Google ScholarÂ
Kaufmann A, Beier V, Franquelim HG, Wollert T. Molecular mechanism of autophagic membrane-scaffold assembly and disassembly. Cell. 2014;156:469–81. https://doi.org/10.1016/j.cell.2013.12.022.
Google ScholarÂ
Iriondo MN, Etxaniz A, Varela YR, Ballesteros U, Hervás JH, Montes LR, et al. LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs. Autophagy. 2022;18:2985–3003. https://doi.org/10.1080/15548627.2022.2062111.
Google ScholarÂ
Tang D, Ni M, Zhu H, Cao J, Zhou L, Shen S, et al. Differential prognostic implications of gastric adenocarcinoma based on Lauren’s classification: a surveillance, epidemiology, and end results (SEER)-based cohort study. Ann Transl Med. 2021;9:646. https://doi.org/10.21037/atm-20-7953.
Google ScholarÂ
Ma J, Shen H, Kapesa L, Zeng S. Lauren classification and individualized chemotherapy in gastric cancer. Oncol Lett. 2016;11:2959–64. https://doi.org/10.3892/ol.2016.4337.
Google ScholarÂ
Ludikhuize MC, Meerlo M, Gallego MP, Xanthakis D, Burgaya Julià M, Nguyen NTB, et al. Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis. Cell Metab. 2020;32:889–900.e7. https://doi.org/10.1016/j.cmet.2020.10.005.
Google ScholarÂ
Haque PS, Kapur N, Barrett TA, Theiss AL. Mitochondrial function and gastrointestinal diseases. Nat Rev Gastroenterol Hepatol. 2024;21:537–55. https://doi.org/10.1038/s41575-024-00931-2.
Google ScholarÂ
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-Parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254. https://doi.org/10.1016/j.redox.2019.101254.
Google ScholarÂ
Panigrahi DP, Praharaj PP, Bhol CS, Mahapatra KK, Patra S, Behera BP, et al. The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics. Semin Cancer Biol. 2020;66:45–58. https://doi.org/10.1016/j.semcancer.2019.07.015.
Google ScholarÂ
Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, et al. Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis. Protein Cell. 2024;15:686–703. https://doi.org/10.1093/procel/pwae004.
Google ScholarÂ
Tomitsuka Y, Imaeda H, Ito H, Asou I, Ohbayashi M, Ishikawa F, et al. Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation. Redox Biol. 2023;66:102850. https://doi.org/10.1016/j.redox.2023.102850.
Google ScholarÂ
Tang B, Zhu J, Wang Y, Chen W, Fang S, Mao W, et al. Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response. Adv Sci (Weinh). 2023;10:e2203973. https://doi.org/10.1002/advs.202203973.
Google ScholarÂ
Gonciarz RL, Collisson EA, Renslo AR. Ferrous iron-dependent pharmacology. Trends Pharm Sci. 2021;42:7–18. https://doi.org/10.1016/j.tips.2020.11.003.
Google ScholarÂ
Ha J, Lee JK, Kim KS, Witters LA, Kim KH. Cloning of human acetyl-CoA carboxylase-beta and its unique features. Proc Natl Acad Sci USA 1996;93:11466–70. https://doi.org/10.1073/pnas.93.21.11466.
Google ScholarÂ
Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci USA 2000;97:1444–9. https://doi.org/10.1073/pnas.97.4.1444.
Google ScholarÂ
Sánchez-Ortega M, Garrido A, Cirauqui C, Sanz-Gonzalez L, Hernández MC, González-GarcÃa A, et al. A potential therapeutic strategy based on acute oxidative stress induction for wild-type NRF2/KEAP1 lung squamous cell carcinoma. Redox Biol. 2024;75:103305. https://doi.org/10.1016/j.redox.2024.103305.
Google ScholarÂ
Sun X, Guo C, Huang C, Lv N, Chen H, Huang H, et al. GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway. Redox Biol. 2024;71:103116. https://doi.org/10.1016/j.redox.2024.103116.
Google ScholarÂ
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011;475:106–9. https://doi.org/10.1038/nature10189.
Google ScholarÂ
Zhao Y, Hu X, Liu Y, Dong S, Wen Z, He W, et al. ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathways. Mol Cancer. 2017;16:79. https://doi.org/10.1186/s12943-017-0648-1.
Google ScholarÂ
Liu Y, Gu W. The complexity of p53-mediated metabolic regulation in tumor suppression. Semin Cancer Biol. 2022;85:4–32. https://doi.org/10.1016/j.semcancer.2021.03.010.
Google ScholarÂ
Neganova M, Liu J, Aleksandrova Y, Klochkov S, Fan R. Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment. Cancers. 2021;13. https://doi.org/10.3390/cancers13236062.
Naushad S, Gaucher J, Mezdari Z, Détrait M, Belaidi E, Zhang Y, et al. Chronic intermittent hypoxia triggers cardiac fibrosis: role of epididymal white adipose tissue senescent remodeling. Acta Physiol 2024;240:e14231. https://doi.org/10.1111/apha.14231.
Google ScholarÂ
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a P53-mediated activity during tumour suppression. Nature. 2015;520:57–62. https://doi.org/10.1038/nature14344.
Google ScholarÂ
Guo H, Ouyang Y, Yin H, Cui H, Deng H, Liu H, et al. Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder. Redox Biol. 2022;49:102227. https://doi.org/10.1016/j.redox.2021.102227.
Google ScholarÂ
Qi Z, Liu R, Ju H, Huang M, Li Z, Li W, et al. microRNA-130b-3p attenuates septic cardiomyopathy by regulating the AMPK/mTOR signaling pathways and directly targeting ACSL4 against ferroptosis. Int J Biol Sci. 2023;19:4223–41. https://doi.org/10.7150/ijbs.82287.
Google ScholarÂ
Casares D, Escribá PV, Rosselló CA. Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues. Int J Mol Sci. 2019;20:2167. https://doi.org/10.3390/ijms20092167.
Google ScholarÂ
Li S, Liu Y, Hu W, Deng A, Ren X, Chen L, et al. Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential. Cell Death Discov. 2025;11:420. https://doi.org/10.1038/s41420-025-02718-z.
Google ScholarÂ
