Kong L, Zhao Q, Han Z, Xue W, Hu Z, Niu Z, et al. Prognostic significance of TG/HDL-C and non-HDL-C/HDL-C ratios in patients with non-small cell lung cancer: a retrospective study. J Int Med Res. 2022;50:3000605221117211. https://doi.org/10.1177/03000605221117211.
Google Scholar
Chen L, Yang S, Jakoncic J, Zhang JJ, Huang X-Y. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010;464:1062–6. https://doi.org/10.1038/nature08978.
Google Scholar
Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, et al. A metastasis map of human cancer cell lines. Nature. 2020;588:331–6. https://doi.org/10.1038/s41586-020-2969-2.
Google Scholar
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CSO, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature 2017;541. https://doi.org/10.1038/nature20791.
Wang Y, Hu M, Cao J, Wang F, Han JR, Wu TW, et al. ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization. Cell. 2025;188:412–e27. https://doi.org/10.1016/j.cell.2024.10.047.
Google Scholar
Jbara A, Lin K-T, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, et al. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature. 2023;617:147–53. https://doi.org/10.1038/s41586-023-05820-3.
Google Scholar
Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572:402–6. https://doi.org/10.1038/s41586-019-1426-6.
Google Scholar
Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2011;123:2292–333. https://doi.org/10.1161/CIR.0b013e3182160726.
Google Scholar
Cho H-C, Lai C-Y, Shao L-E, Yu J. Identification of tumorigenic cells in Kras(G12D)-induced lung adenocarcinoma. Cancer Res. 2011;71:7250–8. https://doi.org/10.1158/0008-5472.CAN-11-0903.
Google Scholar
Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Investig. 1998;101:1–9. https://doi.org/10.1172/JCI1411.
Google Scholar
Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, et al. Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J. 2016;35:2699–716. https://doi.org/10.15252/embj.201695170.
Google Scholar
Wimmer RA, Leopoldi A, Aichinger M, Kerjaschki D, Penninger JM. Generation of blood vessel organoids from human pluripotent stem cells. Nat Protoc. 2019;14:3082–3100. https://doi.org/10.1038/s41596-019-0213-z.
Google Scholar
Jiang S, Li H, Zhang L, Mu W, Zhang Y, Chen T, et al. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics. Nucleic Acids Res. 2025;53:D1670–D1676. https://doi.org/10.1093/nar/gkae973.
Google Scholar
Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023;186:1564–79. https://doi.org/10.1016/j.cell.2023.03.003.
Google Scholar
Sleeman JP, Thiele W. Tumor metastasis and the lymphatic vasculature. Int J Cancer. 2009;125:2747–56. https://doi.org/10.1002/ijc.24702.
Google Scholar
M D, O J, J I. Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration. Curr Opin Cell Biol. 2024;88. https://doi.org/10.1016/j.ceb.2024.102355.
Pawluchin A, Galic M. Moving through a changing world: single cell migration in 2D vs. 3D. Front Cell Dev Biol. 2022;10. https://doi.org/10.3389/fcell.2022.1080995.
Leineweber WD, Fraley SI. Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling. Dev Cell. 2023;58:1414–.e4. https://doi.org/10.1016/j.devcel.2023.05.013.
Google Scholar
Doyle AD, Carvajal N, Jin A, Matsumoto K, Yamada KM. Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. Nat Commun. 2015;6:8720. https://doi.org/10.1038/ncomms9720.
Google Scholar
Saraswathibhatla A, Indana D, Chaudhuri O. Cell-extracellular matrix mechanotransduction in 3D. Nat Rev Mol Cell Biol. 2023;24. https://doi.org/10.1038/s41580-023-00583-1.
Li X, Wang J. Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis. Int J Biol Sci. 2020;16:2014–28. https://doi.org/10.7150/ijbs.44943.
Google Scholar
Gaiko-Shcherbak A, Eschenbruch J, Kronenberg NM, Teske M, Wolters B, Springer R, et al. Cell force-driven basement membrane disruption fuels EGF- and stiffness-induced invasive cell dissemination from benign breast gland acini. Int J Mol Sci. 2021;22:3962. https://doi.org/10.3390/ijms22083962.
Google Scholar
Bertolio R, Napoletano F, Mano M, Maurer-Stroh S, Fantuz M, Zannini A, et al. Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism. Nat Commun. 2019;10:1326. https://doi.org/10.1038/s41467-019-09152-7.
Google Scholar
Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, et al. Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP. Nat Cell Biol. 2019;21:338–47. https://doi.org/10.1038/s41556-018-0270-5.
Google Scholar
Saez Lancellotti TE, Avena MV, Funes AK, Bernal-López M-R, Gómez-Huelgas R, Fornes MW. Exploring the impact of lipid stress on sperm cytoskeleton: insights and prospects. Nat Rev Urol. 2025;22:294–312. https://doi.org/10.1038/s41585-024-00952-1.
Google Scholar
Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, et al. Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses. Cell Rep. 2022;38:110433. https://doi.org/10.1016/j.celrep.2022.110433.
Google Scholar
Liang Y, Zhu Z, Lu Y, Ma C, Li J, Yu K, et al. Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement. Biochim Biophys Acta Mol Cell Biol Lipids. 2025;1870:159610. https://doi.org/10.1016/j.bbalip.2025.159610.
Google Scholar
Yerlikaya FH, Onmaz DE, Selvi Y, Topkafa M, Sivrikaya A, Kaya S, et al. Insomnia patients have a poor intestinal prognosis: accompanied by microbiota-derived short chain fatty acids, diet and zonulin. J Psychiatr Res. 2025;183:25–30. https://doi.org/10.1016/j.jpsychires.2025.01.035.
Google Scholar
Simoni-Nieves A, Salas-Silva S, Chávez-Rodríguez L, Escobedo-Calvario A, Desoteux M, Bucio L, et al. The consumption of cholesterol-enriched diets conditions the development of a subtype of HCC with high aggressiveness and poor prognosis. Cancers. 2021;13:1721. https://doi.org/10.3390/cancers13071721.
Google Scholar
