Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, et al. In vivo epigenetic crispr screen identifies asf1a as an immunotherapeutic target in kras-mutant lung adenocarcinoma. Cancer Discov. 2020;10:270–87.
Google ScholarÂ
Yang J, Xu J, Wang W, Zhang B, Yu X, Shi S. Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 2023;8. https://doi.org/10.1038/s41392-023-01480-x.
Selvakumar SC, Preethi KA, Ross K, Tusubira D, Khan MWA, Mani P, et al. CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer. Mol Cancer. 2022;21:1–14.
Google ScholarÂ
Panda R, Mohan S, Vellapandian C. Harnessing Epigenetic Mechanisms to Overcome Immune Evasion in Cancer: The Current Strategies and Future Directions. Cureus. 2024;16:1–10.
Google ScholarÂ
Wang SW, Gao C, Zheng YM, Yi L, Lu JC, Huang XY, et al. Current applications and future perspective of CRISPR/Cas9 gene editing in cancer. Mol Cancer. 2022;21:1–27.
Google ScholarÂ
Dawalibi A, Bakir M, Mohammad KS. The genetic architecture of bone metastases: Unveiling the role of epigenetic and genetic modifications in drug resistance. Cancer Drug Resist. 2025;8:19.
Kordkheyli VA, Rashidi M, Shokri Y, Fallahpour S, Variji A, Ghara EN, et al. CRISPER/CAS System, a Novel Tool of Targeted Therapy of Drug- Resistant Lung Cancer. Adv Pharm Bull. 2022;12:262–73.
Google ScholarÂ
Al-Musawi S, Kadhim MJ, Hindi NKK. Folated-nanocarrier for paclitaxel drug delivery in leukemia cancer therapy. J Pharmaceutical Sci Res. 2018;10:749–54.
Alnasraui AHF, Al-Musawi S. Nanoformulation of intelligence polymeric nanocarrier for resveratrol targeted delivery and study its cytotoxic, apoptotic, and genetics effects in epidermoid carcinoma therapy. AIP Conf Proc. 2022;2437:020030.
Azmi S, Kunnathodi F, Alotaibi HF, Alhazzani W, Mustafa M, Ahmad I, et al. Harnessing Artificial Intelligence in Obesity Research and Management: A Comprehensive Review. Diagnostics. 2025;15:1–25.
Google ScholarÂ
Srivastav AK, Mishra MK, Lillard JW, Singh R Transforming pharmacogenomics and CRISPR gene editing with the power of artificial intelligence for precision medicine. Pharmaceutics, 17, p.555.
Holcomb EA, Pearson AN, Jungles KM, Tate A, James J, Jiang L, et al. High-content CRISPR screening in tumor immunology. Front Immunol. 2022;13:1–17.
Google ScholarÂ
Alves E, Taifour S, Dolcetti R, Chee J, Nowak AK, Gaudieri S, et al. Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing. Mol Ther Methods Clin Dev. 2021;21:592–606.
Google ScholarÂ
Saleem AA, Al-Kelaby KK. A Review on CRISPR/Cas9 as a Novel Technique for Cancer Therapy. Cell Ther Transplant. 2022;11:10–24.
Google ScholarÂ
Padayachee J, Singh M. Therapeutic applications of CRISPR/Cas9 in breast cancer and delivery potential of gold nanomaterials. Nanobiomedicine. 2020;7:1–15.
Google ScholarÂ
Azangou-Khyavy M, Ghasemi M, Khanali J, Boroomand-Saboor M, Jamalkhah M, Soleimani M, et al. CRISPR/Cas: From Tumor Gene Editing to T Cell-Based Immunotherapy of Cancer. Front Immunol. 2020;11:1–19.
Google ScholarÂ
Banerjee A, Malonia SK, Dutta S. Frontiers of CRISPR-Cas9 for cancer research and therapy. J Exploratory Res Pharmacol. 2021;6:96–104.
Idris OA, Deleon N, Gustafson M, Haj D, Zhang T. Precision Medicine Approaches in Breast Cancer: Current Strategies and Future Directions. In: Monteiro AC, Wang L, editors. Latest Research on Breast Cancer – Molecular Insights, Diagnostic Advances and Therapeutic Innovations. London: IntechOpen; 2024 https://doi.org/10.5772/intechopen.1007670.
Ma SC, Zhang JQ, Yan TH, Miao MX, Cao YM, Cao YB, et al. Novel strategies to reverse chemoresistance in colorectal cancer. Cancer Med. 2023;12:11073–96.
Google ScholarÂ
Qian J, Liu XS. CRISPR/dCas9-Tet1-Mediated DNA Methylation Editing. Bio-protocol. 2024;14:1–14.
Google ScholarÂ
Park M, Ryu H, Heo S, Kim B, Park J, Lim KH, et al. Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer’s disease mouse model. Theranostics. 2025;15:428–38.
Google ScholarÂ
Wang L, Wang E, Prado Balcazar J, Wu Z, Xiang K, Wang Y et al. Chromatin remodeling of colorectal cancer liver metastasis is mediated by an HGF-PU. 1-DPP4 axis. Adv Sci. 2021;8:2004673.
Zhang W, Zhao J, Fan X, Chen S, Wang R. Targeted demethylation of the EphA7 promoter inhibits tumorigenesis via the SP1/DNMT1 and PI3K/AKT axes and improves the response to multiple therapies in cervical cancer. Cell Death Dis. 2025;16:324.
Tejedor JR, Peñarroya A, Gancedo-Verdejo J, Santamarina-Ojeda P, Pérez RF, López-Tamargo S, et al. CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer. Clin Epigenet. 2023;15:1–17.
Google ScholarÂ
Chan WF, Coughlan HD, Chen Y, Keenan CR, Smyth GK, Perkins AC et al. Activation of stably silenced genes by recruitment of a synthetic de-methylating module. Nat Commun. 2022;13:5582.
Xu D, Besselink S, Ramadoss GN, Dierks PH, Lubin JP, Pattali RK et al. Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins. Nat Commun. 2025;16:7948.
Li J, Mahata B, Escobar M, Goell J, Wang K, Khemka P, et al. Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nat Commun. 2021;12:1–10.
Taha BA, Addie AJ, Haider AJ, Jasim AJ, Ahmed NM, Arsad N. Perspective of smart nanocapsule swallowable laser-guided for integrated sensing and crispr-mediated cancer gene editing. Cancer Gene Therapy. 2026;33:351–65.
Taha BA, Addie AJ, Al-Rawi MA, Haider AJ, Yadav AK, Bhatia D, et al. Smart nanophotonics for enzyme-driven drug resistance sensing and controlled therapeutic release. J Drug Deliv Sci Technol. 2025;114:107488.
Google ScholarÂ
Philips TJ, Erickson BK, Thomas SN. Opportunities for predictive proteogenomic biomarkers of drug treatment sensitivity in epithelial ovarian cancer. Front Oncol. 2024;14:1–10.
Wall P, Ideker T. Representing mutations for predicting cancer drug response. Bioinformatics. 2024;40:i160–i168.
Google ScholarÂ
Jilani M, Degras D, Haspel N. Elucidating Cancer Subtypes by Using the Relationship between DNA Methylation and Gene Expression. Genes. 2024;15. https://doi.org/10.3390/genes15050631.
Young JD, Ren S, Chen L, Lu X. Revealing the Impact of Genomic Alterations on Cancer Cell Signaling with an Interpretable Deep Learning Model. Cancers. 2023;15:1–24.
Google ScholarÂ
Wang C, Lye X, Kaalia R, Kumar P, Rajapakse JC. Deep learning and multi-omics approach to predict drug responses in cancer. BMC Bioinformatics. 2021;22:1–15.
Chen J, Guan B, Zhang J, Li X, Fang J, Guan W, et al. Development of CSOARG: a single-cell and multi-omics-based machine learning model for ovarian cancer prognosis and drug response prediction. Front Oncol. 2025;15:1–16.
Google ScholarÂ
van der Graaff D, Seghers S, Vanclooster P, Deben C, Vandamme T, Prenen H. Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer. Cancers. 2024;16:1–20.
Youssef E, Fletcher B, Palmer D. Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology. Front Med. 2024;11:1–24.
McAndrews KM, Xiao F, Chronopoulos A, LeBleu VS, Kugeratski FG, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021;4:1–13.
Google ScholarÂ
Gier RA, Budinich KA, Evitt NH, Cao Z, Freilich ES, Chen Q, et al. High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening. Nat Commun. 2020;11:1–9.
Google ScholarÂ
Dhar S. Precision Oncology: Current Status of Targeted Therapies and Prospective Advances. Prem J Sci. 2025;5. https://doi.org/10.70389/PJS.100039.
Sheikh M, Jirvankar PS. Harnessing artificial intelligence for enhanced nanoparticle design in precision oncology. AIMS Bioeng. 2024;11:574–97.
Google ScholarÂ
Guo C, Ma X, Gao F, Guo Y. Off-target effects in CRISPR/Cas9 gene editing. Front Bioeng Biotechnol. 2023;11:1–11.
Google ScholarÂ
Rauf MA, Rao A, Sivasoorian SS, Iyer AK. Nanotechnology-Based Delivery of CRISPR/Cas9 for Cancer Treatment: A Comprehensive Review. Cells. 2025;14:1–22.
Google ScholarÂ
Song Z, Tao Y, Liu Y, Li J. Advances in delivery systems for CRISPR/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles. Front Immunol. 2024;15:1–23.
Google ScholarÂ
Karimi MA, Paryan M, Fard GB, Sadeghian H, Zarrinfar H, Bafghi MH. Challenges and opportunities in the application of CRISPR-Cas9: a review on genomic editing and therapeutic potentials. Med Princ Pract. 2026;35:1–17.
Ajutor LJ, Agbo OS, Adobor CA, Iyoyojie BA, Ugoagwu KU, Manawa O, et al. Gene Editing in Cancer Immunotherapy: Mechanisms, Advancements, Limitations and Future Directions. Asian J Biochem Genet Mol Biol. 2024;16:121–35.
Google ScholarÂ
Barber HM, Pater AA, Gagnon KT, Damha MJ, O’Reilly D. Chemical engineering of CRISPR–Cas systems for therapeutic application. Nat Rev Drug Discov. 2025;24:209–30.
Google ScholarÂ
Freedman BS, Bulte JWM, Conklin BR, Judge LM, Dwinell MR, Geurts AM, et al. Monitoring biological effects of somatic cell genome editing. Nat Rev Genet. 2026;27:323–42.
Google ScholarÂ
Thomson T, Li G, Strilchuk A, Cui H, Wang B, Li B. Harnessing artificial intelligence to advance CRISPR-based genome editing technologies. Nat Rev Genet. 2026;27:212–30.
Google ScholarÂ
Niazi SK. Quantum Mechanics in Drug Discovery: A Comprehensive Review of Methods, Applications, and Future Directions. Int J Mol Sci. 2025;26:1–20.
Google ScholarÂ
Uddin F, Rudin CM, Sen T. CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future. Front Oncol. 2020;10. https://doi.org/10.3389/fonc.2020.01387.
Saklani S, Barsola B, Pathania D, Sonu S, Kumari P, Singh P et al. Nanomaterials-Integrated Electrochemical Biosensors as Pioneering Solutions for Zoonotic Disease Diagnosis. J Electrochem Soc. 2024;171. https://doi.org/10.1149/1945-7111/ad65bb.
Taha BA, Al-Tahar IA, Addie AJ, Mahdi AB, Haider AJ, Mashhadany Y Al, et al. Nanophotonic catheters: A lens into the body for biosensing and biomedical imaging. Appl Mater Today. 2024;38:102229.
Google ScholarÂ
Taha BA, Addie AJ, Saeed AQ, Haider AJ, Chaudhary V, Arsad N. Nanostructured photonics probes: a transformative approach in neurotherapeutics and brain circuitry. Neuroscience. 2024;562:106–24.
Google ScholarÂ
Pasupuleti MK. AI-Driven mRNA and CRISPR Breakthroughs: Engineering the Future of Universal Cancer Vaccines. In: Universal Cancer Vaccine Using Personalized mRNA and CRISPR Technology. New Delhi, India: National Education Services;2025, pp. 92–107.
Srivastava R. Quantum computing in drug discovery. Inf Syst Smart City. 2023;3:294.
Google ScholarÂ
Gamal H, Mostafa Shoeib E, Hajjaj A, Elsafy Abdelaziz Abdullah H, Elramy EH, Ahmed Abd Ellah D, et al. Incorporating AI, in silico, and CRISPR technologies to uncover the potential of repurposed drugs in cancer therapy. RSC Pharm. 2025;2:1019–33.
Google ScholarÂ
Taha BA, Addie AJ, Haider AJ, Norhana A. Nanosensors Based on Breathomics for Human Disease Diagnosis: a New Frontier in Personalized Healthcare. Bionanoscience. 2025. https://doi.org/10.1007/s12668-025-01876-9.
Taha BA, Al-Rawi MA, Addie AJ, Abdulateef SA, Haider AJ, Chaudhary V, et al. Nanomaterial-enhanced biosensors for polycystic ovarian syndrome diagnosis and pathophysiological insights. Microchim Acta. 2025;192:547.
Google ScholarÂ
Haider AJ, Al-Musawi S, Alnayli RS, Al-Obaidy R, Addie AJ, Abbas SF, et al. Superparamagnetic Iron Oxide Nanoparticles: Multifunctional Targeted Platforms for Cancer Detection and Combination Therapy. Bionanoscience. 2025;15:547.
Google ScholarÂ
Talib SM, Haider AJ, Al-musawi S, Hussein A, Alnasraui F, Talib LM, et al. Design and construction of platinum – zinc oxide grafted honey-chitosan nanofibers loaded with hesperidin and study its antibacterial and wound healing effects. Mater Chem Phys. 2025;345:131249.
Google ScholarÂ
Taha BA, Addie AJ, Kolie LFZ, Wahhab ST, Abdulateef SA, Haider AJ et al. Advancements in nanophotonics and smart nanomaterials integrated with artificial intelligence-driven gene editing: A paradigm shift in cancer diagnosis and therapeutic. Chin Chem Lett. 2025;37:111955.
Taha BA, Sulaiman GM, Addie AJ, Khalil KAA, Ahmed EM, Chaudhary V, et al. Multifunctional nanophotonic photoacoustic biosensors: a new era in molecular imaging – guided deep-tissue cancer monitoring. Methods. 2025;242:1–23.
Google ScholarÂ
