Bjornsson HT, Daniele Fallin M, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 2004;20:350–8.
Google Scholar
Talens RP, Christensen K, Putter H, Willemsen G, Christiansen L, Kremer D, et al. Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell. 2012;11:694–703.
Google Scholar
Morata G, Ripoll P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev Biol. 1975;42:211–21.
Google Scholar
Oliver ER, Saunders TL, Tarlé SA, Glaser T. Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development. 2004;131:3907–20.
Google Scholar
de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA. Drosophila Myc regulates organ size by inducing cell competition. Cell. 2004;117:107–16.
Google Scholar
Moreno E, Basler K. dMyc transforms cells into super-competitors. Cell. 2004;117:117–29.
Google Scholar
van Neerven SM, de Groot NE, Nijman LE, Scicluna BP, van Driel MS, Lecca MC, et al. Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature. 2021;594:436–41.
Google Scholar
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, et al. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature. 2021;594:430–5.
Google Scholar
Clavería C, Giovinazzo G, Sierra R, Torres M. Myc-driven endogenous cell competition in the early mammalian embryo. Nature. 2013;500:39–44.
Google Scholar
Hashimoto M, Sasaki H. Epiblast formation by TEAD-YAP-dependent expression of pluripotency factors and competitive elimination of unspecified cells. Dev Cell. 2019;50:139–54.e5.
Google Scholar
Alcolea MP, Jones PH. Cell competition: winning out by losing notch. Cell Cycle. 2015;14:9–17.
Google Scholar
Rodrigues AB, Zoranovic T, Ayala-Camargo A, Grewal S, Reyes-Robles T, Krasny M, et al. Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. Development. 2012;139:4051–61.
Google Scholar
Moreno E, Valon L, Levillayer F, Levayer R. Competition for space induces cell elimination through compaction-driven ERK downregulation. Curr Biol. 2019;29:23–34.e8.
Google Scholar
Murai K, Skrupskelyte G, Piedrafita G, Hall M, Kostiou V, Ong SH, et al. Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations. Cell Stem Cell. 2018;23:687–99.e8.
Google Scholar
Vermeulen L, Morrissey E, Van Der Heijden M, Nicholson AM, Sottoriva A, Buczacki S, et al. Defining stem cell dynamics in models of intestinal tumor initiation. Science. 2013;342:995–8.
Google Scholar
Yum MK, Han S, Fink J, Wu SHS, Dabrowska C, Trendafilova T, et al. Tracing oncogene-driven remodelling of the intestinal stem cell niche. Nature. 2021;594:442–7.
Google Scholar
Hill W, Zaragkoulias A, Salvador-Barbero B, Parfitt GJ, Alatsatianos M, Padilha A, et al. EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas. Curr Biol. 2021;31:2550–60.e5.
Google Scholar
Salvador-Barbero B, Alatsatianos M, Morton JP, Sansom OJ, Hogan C. KRASG12D cells override homeostatic cell elimination mechanisms in adult pancreas via Wnt5a and cell dormancy. Gastroenterology. 2025;169:983–99.e21.
Google Scholar
Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, et al. The evolutionary history of 2,658 cancers. Nature. 2020;578:122–8.
Google Scholar
Currie CE, Ford E, Benham Whyte L, Taylor DM, Mihalas BP, Erent M, et al. The first mitotic division of human embryos is highly error prone. Nat Commun. 2022;13:1–13.
Google Scholar
Mashiko D, Ikeda Z, Yao T, Tokoro M, Fukunaga N, Asada Y et al. Chromosome segregation error during early cleavage in mouse pre-implantation embryo does not necessarily cause developmental failure after blastocyst stage. Sci Rep. 2020;10:854.
Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB, Rahbari R, et al. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo. Nature. 2017;543:714–8.
Google Scholar
Matsumoto K, Akieda Y, Haraoka Y, Hirono N, Sasaki H, Ishitani T. Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Nat Commun. 2024;15:1–18.
Google Scholar
Ya A, Deng C, Godek KM. Cell competition eliminates aneuploid human pluripotent stem cells. Stem Cell Rep. 2025;20:102506.
Google Scholar
Sancho M, Di-Gregorio A, George N, Pozzi S, Sánchez JM, Pernaute B, et al. Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation. Dev Cell. 2013;26:19–30.
Google Scholar
Kolahgar G, Suijkerbuijk SJE, Kucinski I, Poirier EZ, Mansour S, Simons BD, et al. Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT-dependent manner. Dev Cell. 2015;34:297–309.
Google Scholar
Rhiner C, Díaz B, Portela M, Poyatos JF, Fernández-Ruiz I, López-Gay JM, et al. Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche. Development. 2009;136:995–1006.
Google Scholar
Ellis SJ, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E. Distinct modes of cell competition shape mammalian tissue morphogenesis. Nature. 2019;569:497–502.
Google Scholar
Barker N, Van Es JH, Kuipers J, Kujala P, Van Den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003–7.
Google Scholar
Barker N. Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol. 2013;15:19–33.
Google Scholar
Kozar S, Morrissey E, Nicholson AM, van der Heijden M, Zecchini HI, Kemp R, et al. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell. 2013;13:626–33.
Google Scholar
Ritsma L, Ellenbroek SIJ, Zomer A, Snippert HJ, De Sauvage FJ, Simons BD, et al. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature. 2014;507:362–5.
Google Scholar
Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. Intestinal stem cell replacement follows a pattern of neutral drift. Science. 2010;330:822–5.
Google Scholar
Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010;143:134–44.
Google Scholar
Snippert HJ, Schepers AG, Van Es JH, Simons BD, Clevers H. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO Rep. 2014;15:62–69.
Google Scholar
Bondar T, Medzhitov R. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell. 2010;6:309–22.
Google Scholar
Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, et al. Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells. Cell Stem Cell. 2020;26:377–90.e6.
Google Scholar
Hageman JH, Heinz MC, Kretzschmar K, van der Vaart J, Clevers H, Snippert HJG. Intestinal regeneration: regulation by the microenvironment. Dev Cell. 2020;54:435–46.
Google Scholar
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194–217.
Google Scholar
Luo J, Mills K, le Cessie S, Noordam R, van Heemst D. Ageing, age-related diseases and oxidative stress: What to do next? Ageing Res Rev. 2020;57:100982.
Google Scholar
Rando TA, Wyss-Coray T. Asynchronous, contagious and digital aging. Nat Aging. 2021;1:29–35.
Google Scholar
Marques-Reis M, Moreno E. Role of cell competition in ageing. Dev Biol. 2021;476:79–87.
Google Scholar
Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E. Elimination of unfit cells maintains tissue health and prolongs lifespan. Cell. 2015;160:461–76.
Google Scholar
Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, et al. Stem cell competition orchestrates skin homeostasis and ageing. Nature. 2019;568:344–50.
Google Scholar
Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, et al. Filamin acts as a key regulator in epithelial defence against transformed cells. Nat Commun. 2014;5:1–13.
Google Scholar
Hogan C, Dupré-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, et al. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol. 2009;11:460–7.
Google Scholar
Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, et al. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci. 2010;123:171–80.
Google Scholar
Chiba T, Ishihara E, Miyamura N, Narumi R, Kajita M, Fujita Y, et al. MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Sci Rep. 2016;6:1–10.
Google Scholar
Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, et al. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nat Cell Biol. 2017;19:530–41.
Google Scholar
Pothapragada SP, Gupta P, Mukherjee S, Das T. Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin. Nat Commun. 2022;13:1–12.
Google Scholar
Sato N, Yako Y, Maruyama T, Ishikawa S, Kuromiya K, Tokuoka SM, et al. The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia. Commun. Biol. 2020;3:1–11.
Google Scholar
Sasaki A, Nagatake T, Egami R, Gu G, Takigawa I, Ikeda W, et al. Obesity suppresses cell-competition-mediated apical elimination of RasV12-transformed cells from epithelial tissues. Cell Rep. 2018;23:974–82.
Google Scholar
Watanabe H, Ishibashi K, Mano H, Kitamoto S, Sato N, Hoshiba K, et al. Mutant p53-expressing cells undergo necroptosis via cell competition with the neighboring normal epithelial cells. Cell Rep. 2018;23:3721–9.
Google Scholar
Kohashi K, Mori Y, Narumi R, Kozawa K, Kamasaki T, Ishikawa S, et al. Sequential oncogenic mutations influence cell competition. Curr Biol. 2021;31:3984–95.e5.
Google Scholar
Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S, et al. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015;348:880–6.
Google Scholar
Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, et al. The landscape of somatic mutation in normal colorectal epithelial cells. Nature. 2019;574:532–7.
Google Scholar
Martincorena I, Raine KM, Gerstung M, Dawson KJ, Haase K, Van Loo P, et al. Universal patterns of selection in cancer and somatic tissues. Cell. 2017;171:1029–41.e21.
Google Scholar
Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH. Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol. 2014;16:612–9.
Google Scholar
Fernandez-Antoran D, Piedrafita G, Murai K, Ong SH, Herms A, Frezza C, et al. Outcompeting p53-mutant cells in the normal esophagus by redox manipulation. Cell Stem Cell. 2019;25:329–41.e6.
Google Scholar
Liu Z, Yee PP, Wei Y, Liu Z, Kawasawa YI, Li W. Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis. J Cell Sci. 2019;132:jcs225714.
Google Scholar
Amoyel M, Simons BD, Bach EA. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J. 2014;33:2295–313.
Google Scholar
Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien C-B, Morcos PA, et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature. 2012;484:546–9.
Google Scholar
Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, et al. Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun. 2016;7:1–14.
Google Scholar
Norman M, Wisniewska KA, Lawrenson K, Garcia-Miranda P, Tada M, Kajita M, et al. Loss of Scribble causes cell competition in mammalian cells. J Cell Sci. 2012;125:59–66.
Google Scholar
Qin Y, Capaldo C, Gumbiner BM, Macara IG. The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol. 2005;171:1061–71.
Google Scholar
Pereira AM, Tudor C, Kanger JS, Subramaniam V, Martin-Blanco E. Integrin-dependent activation of the JNK signaling pathway by mechanical stress. PLoS ONE. 2011;6:e26182.
Google Scholar
Levayer R, Dupont C, Moreno E. Tissue crowding induces caspase-dependent competition for space. Curr Biol. 2016;26:670–7.
Google Scholar
Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, et al. Role of YAP/TAZ in mechanotransduction. Nature. 2011;474:179–84.
Google Scholar
Porazinski S, de Navascués J, Yako Y, Hill W, Jones MR, Maddison R, et al. EphA2 drives the segregation of ras-transformed epithelial cells from normal neighbors. Curr Biol. 2016;26:3220–9.
Google Scholar
Hill W, Hogan C. Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level. Small GTPases. 2019;10:305–10.
Google Scholar
Leung CT, Brugge JS. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature. 2012;482:410–3.
Google Scholar
Brown S, Pineda CM, Xin T, Boucher J, Suozzi KC, Park S, et al. Correction of aberrant growth preserves tissue homeostasis. Nature. 2017;548:334–7.
Google Scholar
Ayukawa S, Kamoshita N, Nakayama J, Teramoto R, Pishesha N, Ohba K, et al. Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction. Nat Immunol. 2021;22:1391–402.
Google Scholar
Soares CC, Rizzo A, Maresma MF, Meier P. Autocrine glutamate signaling drives cell competition in Drosophila. Dev Cell. 2024;59:2974–89.e5.
Google Scholar
Vincent J-P, Kolahgar G, Gagliardi M, Piddini E. Steep differences in wingless signaling trigger Myc-independent competitive cell interactions. Dev Cell. 2011;21:366–74.
Google Scholar
Mori Y, Shiratsuchi N, Sato N, Chaya A, Tanimura N, Ishikawa S, et al. Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis. Curr Biol. 2022;32:2144–59.e5.
Google Scholar
Nakai K, Lin H, Yamano S, Tanaka S, Kitamoto S, Saitoh H, et al. Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway. Nat Commun. 2023;14:1–17.
Google Scholar
Urzì O, Gasparro R, Costanzo E, De Luca A, Giavaresi G, Fontana S, et al. Three-dimensional cell cultures: the bridge between in vitro and in vivo models. Int J Mol Sci. 2023;24:12046.
Google Scholar
Kapałczyńska M, Kolenda T, Przybyła W, Zajączkowska M, Teresiak A, Filas V, et al. 2D and 3D cell cultures—a comparison of different types of cancer cell cultures. Arch Med Sci. 2016;14:910.
Google Scholar
Ogawa M, Kawarazaki Y, Fujita Y, Naguro I, Ichijo H. FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells. Curr Biol. 2021;31:1048–57.e5.
Google Scholar
Senoo-Matsuda N, Johnston LA. Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc. Proc Natl Acad Sci USA. 2007;104:18543–8.
Google Scholar
Shi J, Wang E, Milazzo JP, Wang Z, Kinney JB, Vakoc CR. Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nat Biotechnol. 2015;33:661–7.
Google Scholar
Girish V, Sheltzer JM. A CRISPR competition assay to identify cancer genetic dependencies. Bio Protoc. 2020;10:e3682.
Google Scholar
Lin A, Giuliano CJ, Sayles NM, Sheltzer JM. CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials. eLife. 2017;6:e24179.
Google Scholar
Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, et al. Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer. Oncol Rep. 2015;33:1837–43.
Google Scholar
van Neerven SM, Ramadan R, van Driel MS, Huels DJ, Vermeulen L. Intestinal organoid co-culture protocol to study cell competition. STAR Protoc. 2022;3:101050.
Google Scholar
Baglamis S, Sheraton VM, Meijer D, Qian H, Hoebe RA, Lenos KJ, et al. Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures. Sci Rep. 2023;13:18832.
Google Scholar
Krotenberg Garcia A, Fumagalli A, Le HQ, Jackstadt R, Lannagan TRM, Sansom OJ, et al. Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Rep. 2021;36:109307.
Google Scholar
Birey F, Andersen J, Makinson CD, Islam S, Wei W, Huber N, et al. Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54–9.
Google Scholar
Kim JL, Imaizumi K, Jurjuț O, Kelley KW, Wang D, Thete MV, et al. Human assembloid model of the ascending neural sensory pathway. Nature. 2025;642:143–53.
Google Scholar
Herms A, Fernandez-Antoran D, Alcolea MP, Kalogeropoulou A, Banerjee U, Piedrafita G, et al. Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium. Nat Genet. 2024;56:2158–73.
Google Scholar
Herms A, Colom B, Piedrafita G, Kalogeropoulou A, Banerjee U, King C, et al. Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus. Nat Genet. 2024;56:2144–57.
Google Scholar
Tsai H-F, Trubelja A, Shen AQ, Bao G. Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment. J R Soc Interface. 2017;14:20170137.
Google Scholar
Seaman K, Sun Y, You L. Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment. Med-X. 2023;1:1–28.
Google Scholar
Lorenzo-Martín LF, Hübscher T, Bowler AD, Broguiere N, Langer J, Tillard L, et al. Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo. Nature. 2024;629:450–7.
Google Scholar
De La Cova C, Senoo-Matsuda N, Ziosi M, Wu DC, Bellosta P, Quinzii CM, et al. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014;19:470–83.
Google Scholar
Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, et al. Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA. 2010;107:20009–14.
Google Scholar
Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005;121:335–48.
Google Scholar
Lenos KJ, Miedema DM, Lodestijn SC, Nijman LE, van den Bosch T, Romero Ros X, et al. Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer. Nat Cell Biol. 2018;20:1193–202.
Google Scholar
Di Giacomo S, Sollazzo M, De Biase D, Ragazzi M, Bellosta P, Pession A, et al. Human cancer cells signal their competitive fitness through MYC activity. Sci Rep. 2017;7:1–12.
Google Scholar
Cattaneo CM, Dijkstra KK, Fanchi LF, Kelderman S, Kaing S, van Rooij N, et al. Tumor organoid–T-cell coculture systems. Nat Protoc. 2019;15:15–39.
Google Scholar
Zhu Y, Wunderlich Z, Lander AD. Epithelial cell competition is promoted by signaling from immune cells. Nat Commun. 2025;16:1–15.
Zhang X, Li S, Malik I, Do MH, Ji L, Chou C, et al. Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature. 2023;619:616–23.
Google Scholar
Bove A, Gradeci D, Fujita Y, Banerjee S, Charras G, Lowe AR. Local cellular neighborhood controls proliferation in cell competition. Mol Biol Cell. 2017;28:3215–28.
Google Scholar
Gradeci D, Bove A, Charras G, Lowe AR, Banerjee S. Single-cell approaches to cell competition: High-throughput imaging, machine learning and simulations. Semin Cancer Biol. 2020;63:60–68.
Google Scholar
Fetah KL, DiPardo BJ, Kongadzem EM, Tomlinson JS, Elzagheid A, Elmusrati M, et al. Cancer modeling-on-a-chip with future artificial intelligence integration. Small. 2019;15:1901985.
Google Scholar
Shaw I, Ali YS, Nie C, Zhang K, Chen C, Xiao Y. Integrating artificial intelligence and microfluidics technology for psoriasis therapy: a comprehensive review for research and clinical applications. Adv Intell Syst. 2025;7:2400558.
Google Scholar
Knapp K, Verchio V, Coburn-Flynn O, Li Y, Xiong Z, Morrison JC, et al. Exploring cell competition for the prevention and therapy of esophageal squamous cell carcinoma. Biochem Pharmacol. 2023;214:115639.
Google Scholar
Zhang L, Atencia Taboada L, Baglamis S, de Kroon M, Elshout C, Ramesh P, et al. GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells. Oncogenesis. 2025;14:1–8.
Google Scholar
Yamauchi H, Matsumaru T, Morita T, Ishikawa S, Maenaka K, Takigawa I, et al. The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia. Sci Rep. 2015;5:1–9.
Google Scholar
Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnová M, Piechaczyk L, et al. A cell competition–based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation. J Biol Chem. 2020;296:100179.
Google Scholar
Linssen JDG, van Neerven SM, Aelvoet AS, Elbers CC, Vermeulen L, Dekker E. The CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial. BMC Gastroenterol. 2022;22:1–9.
Google Scholar
Paraskevopoulos M, McGuigan AP. Application of CRISPR screens to investigate mammalian cell competition. Brief Funct Genom. 2021;20:135–47.
Google Scholar
Meng X, Yao D, Imaizumi K, Chen X, Kelley KW, Reis N, et al. Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment. Nature. 2023;622:359–66.
Google Scholar
Pylvänäinen JW, Gómez-de-Mariscal E, Henriques R, Jacquemet G. Live-cell imaging in the deep learning era. Curr Opin Cell Biol. 2023;85:102271.
Google Scholar

