Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6:92.
Google Scholar
Pfister DG, Spencer S, Brizel DM, Burtness B, Busse PM, Caudell JJ, et al. Head and neck cancers, version 2.2014. J Natl Compr Cancer Netw. 2014;12:1454–87.
Google Scholar
Berzenji D, Sewnaik A, Keereweer S, Monserez DA, Verduijn GM, van Meerten E, et al. Dissemination patterns and chronology of distant metastasis affect survival of patients with head and neck squamous cell carcinoma. Oral Oncol. 2021;119:105356.
Google Scholar
Pisani P, Airoldi M, Allais A, Valletti PA, Battista M, Benazzo M, et al. Metastatic disease in head & neck oncology. Acta Otorhinolaryngol Ital. 2020;40:S1.
Google Scholar
Hrycaj SM, Wellik DM. Hox genes and evolution. Research. 2016;5:859.
Wang Y, Dang Y, Liu J, Ouyang X. The function of homeobox genes and lncRNAs in cancer. Oncol Lett. 2016;12:1635–41.
Google Scholar
Bhatlekar S, Fields JZ, Boman BM. Role of HOX genes in stem cell differentiation and cancer. Stem Cells Int. 2018;2018:3569493.
Google Scholar
Li B, Huang Q, Wei G-H. The role of HOX transcription factors in cancer predisposition and progression. Cancers. 2019;11:528.
Google Scholar
Brotto, Siena DB, de Barros II ÁDD, Carvalho, SdCeS, Muys BR, et al. Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review. Tumor Biol. 2020;42:1010428320918050.
Google Scholar
Yan T, Ooi WF, Qamra A, Cheung A, Ma D, Sundaram GM, et al. HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. Nat Commun. 2018;9:100.
Google Scholar
Yan T-f, Wu M-j, Xiao B, Hu Q, Fan Y-H, Zhu X-G. Knockdown of HOXC6 inhibits glioma cell proliferation and induces cell cycle arrest by targeting WIF-1 in vitro and in vivo. Pathol-Res Pract. 2018;214:1818–24.
Google Scholar
Wang Y, Wang C, Liu N, Hou J, Xiao W, Wang H. HOXC6 promotes cervical cancer progression via regulation of Bcl-2. FASEB J. 2019;33:3901–11.
Google Scholar
Yang Y, Tang X, Song X, Tang L, Cao Y, Liu X, et al. Evidence for an oncogenic role of HOXC6 in human non-small cell lung cancer. PeerJ. 2019;7:e6629.
Google Scholar
Gong C, Zou J, Zhang M, Zhang J, Xu S, Zhu S, et al. Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer. Mol Carcinogenesis. 2019;58:1863–75.
Google Scholar
Hu M, Ou-Yang W, Jing D, Chen R. Clinical prognostic significance of HOXC9 expression in patients with colorectal cancer. Clin Lab. 2019;65:10.
Google Scholar
Guan Y, He Y, Lv S, Hou X, Li L, Song J. Overexpression of HOXC10 promotes glioblastoma cell progression to a poor prognosis via the PI3K/AKT signalling pathway. J Drug Target. 2019;27:60–6.
Google Scholar
Dai BW, Yang ZM, Deng P, Chen YR, He ZJ, Yang X, et al. HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. J Cancer. 2019;10:4540–51.
Google Scholar
Zhou Y, Huang Q, Wu C, Xu Y, Guo Y, Yuan X. et al. m(6)A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/beta‑catenin signaling. Int J Oncol. 2024;64:10
Google Scholar
Cui Y, Zhang C, Wang Y, Ma S, Cao W, Guan F. HOXC11 functions as a novel oncogene in human colon adenocarcinoma and kidney renal clear cell carcinoma. Life Sci. 2020;243:117230.
Google Scholar
Wang X, Sun Y, Peng X, Naqvi SMAS, Yang Y, Zhang J, et al. The tumorigenic effect of sphingosine kinase 1 and its potential therapeutic target. Cancer Control. 2020;27:1073274820976664.
Google Scholar
Zhu L, Yan D, Chen Y, Chen S, Chen N, Han J. The identification of autophagy-related genes in the prognosis of oral squamous cell carcinoma. Oral Dis. 2020;26:1659–67.
Google Scholar
Karki BB, Wu D, Shen J. Sphingosine kinase 1 (SphK1)–a novel marker for cancer risk assessment in oral premalignancy. Nepal Med J. 2021;4:58–67.
Peng X, Liu X, Hu W, Zhou Y, Ouyang L, Peng X, et al. HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1. Cell Death Dis. 2023;14:153.
Google Scholar
Abalkhail KA, Kukuruzinska MA. Emerging insights into Wnt/beta-catenin signaling in head and neck cancer. J Dent Res. 2018;97:665–73.
Google Scholar
Wang Q, Meng D, Shen S, Cao Y, Zhang P, Liu Y, et al. P4HA3 promotes head and neck squamous cell carcinoma progression via the WNT/beta-catenin signaling pathway. Pathol Res Pract. 2024;260:155481.
Google Scholar
Liu H, Zhang CX, Ma Y, He HW, Wang JP, Shao RG. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/beta-catenin signaling pathway. Life Sci. 2016;151:23–9.
Google Scholar
Khijmatgar S, Yong J, Rübsamen N, Lorusso F, Rai P, Cenzato N, et al. Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis. Jpn Dent Sci Rev. 2024;60:32–9.
Google Scholar
Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A. Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci. 2023;11:42.
Google Scholar
Li J, Feng L, Yuan Y, He T, Zou X, Su B, et al. Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway. World J Surg Oncol. 2024;22:1–16.
Google Scholar
Liu L, Jia S, Jin X, Zhu S, Zhang S. HOXC11 expression is associated with the progression of colon adenocarcinoma and is a prognostic biomarker. DNA Cell Biol. 2021;40:1158–66.
Google Scholar
Chu S, Ren X, Cao L, Ma C, Wang K. HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer. BMC Cancer. 2024;24:921.
Google Scholar
Padam KSR, Morgan R, Hunter K, Chakrabarty S, Kumar NA, Radhakrishnan R. Identification of HOX signatures contributing to oral cancer phenotype. Sci Rep. 2022;12:10123.
Google Scholar
Yang J, Li J, Li S, Yang Y, Su H, Guo H, et al. Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell type in endometrial cancer. Mol Biomed. 2024;5:32.
Google Scholar
Hou C-x, Mao G-y, Sun Q-w, Meng Y, Zhu Q-h, Tang Y-t, et al. Metabolomic analysis reveals that SPHK1 promotes oral squamous cell carcinoma progression through NF-κB activation. Ann Surg Oncol. 2022;29:7386–99.
Google Scholar
Tamashiro PM, Furuya H, Shimizu Y, Iino K, Kawamori T. The impact of sphingosine kinase-1 in head and neck cancer. Biomolecules. 2013;3:481–513.
Google Scholar
Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, et al. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res. 2011;4:454–62.
Google Scholar
Long J, Yao Z, Sui Y, Fang S. SphK1 promotes cancer progression through activating the JAK/STAT pathway and up-regulating S1PR1 expression in colon cancer cells. Anti-Cancer Agents Med Chem. 2022;22:254–60.
Google Scholar
Jin L, Zhu J, Yao L, Shen G, Xue B-x, Tao W. Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth. Cell Death Dis. 2023;14:537.
Google Scholar
Shakeel I, Haider S, Khan S, Ahmed S, Hussain A, Alajmi MF, et al. Thymoquinone, artemisinin, and thymol attenuate the proliferation of lung cancer cells as Sphingosine kinase 1 inhibitors. Biomed Pharmacother. 2024;177:117123.
Google Scholar
Kao W-H, Liao L-Z, Chen Y-A, Lo U-G, Pong R-C, Hernandez E, et al. SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade. Cell Death Dis. 2024;15:678.
Google Scholar
Alkafaas SS, Elsalahaty MI, Ismail DF, Radwan MA, Elkafas SS, Loutfy SA, et al. The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target. Cancer Cell Int. 2024;24:89.
Google Scholar
Smith J, Zyoud A, Allegrucci C. A case of identity: HOX genes in normal and cancer stem cells. Cancers. 2019;11:512.
Google Scholar
Neijts R, Amin S, van Rooijen C, Deschamps J. Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology. Dev Biol. 2017;422:146–54.
Google Scholar
Fu Z, Chen C, Zhou Q, Wang Y, Zhao Y, Zhao X, et al. LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9. Cancer Lett. 2017;410:68–81.
Google Scholar
Ordóñez-Morán P, Dafflon C, Imajo M, Nishida E, Huelsken J. HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer. Cancer cell. 2015;28:815–29.
Google Scholar
