Braekeleer M, Tous C, Guéganic N, Le Bris MJ, Basinko A, Morel F, et al. Immunoglobulin gene translocations in chronic lymphocytic leukemia: a report of 35 patients and review of the literature. Mol Clin Oncol. 2016;4:682–94.
Google Scholar
Nagel I, Szczepanowski M, Martín-Subero JI, Harder L, Akasaka T, Ammerpohl O, et al. Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies. Blood. 2010;116:1317–20.
Google Scholar
Siebert R, Rosenwald A, Staudt LM, Morris SW. Molecular features of B-cell lymphoma. Curr Opin Oncol. 2001;13:316–24.
Google Scholar
Dyer MJS, Akasaka T, Capasso M, Dusanjh P, Lee YF, Karran EL, et al. Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers? Blood. 2010;115:1490–9.
Google Scholar
Boxer LM, Dang CV. Translocations involving c-myc and c-myc function. Oncogene. 2001;20:5595–610.
Google Scholar
Hecht JL, Aster JC. Molecular biology of Burkitt’s lymphoma. J Clin Oncol. 2000;18:3707–21.
Google Scholar
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th edition. Lyon: International Agency for Research on Cancer; 2017. 585 p. (World Health Organization classification of tumours).
Ueshima Y, Haren JM, Bird ML, Rowley JD. Culture conditions in chronic lymphocytic leukemia: relationship to karyotype. Leukemia. 1989;3:192–4.
Google Scholar
Baliakas P, Espinet B, Mellink C, Jarosova M, Athanasiadou A, Ghia P, et al. Cytogenetics in chronic lymphocytic leukemia: ERIC perspectives and recommendations. Hemasphere. 2022;6:e707.
Google Scholar
Decker T, Schneller F, Kronschnabl M, Dechow T, Lipford GB, Wagner H, et al. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: Costimulation with IL-2 results in a highly immunogenic phenotype. Exp Hematol. 2000;28:558–68.
Google Scholar
Dicker F, Schnittger S, Haferlach T, Kern W, Schoch C. Immunostimulatory oligonucleotide-induced metaphase cytogenetics detect chromosomal aberrations in 80% of CLL patients: A study of 132 CLL cases with correlation to FISH, IgVH status, and CD38 expression. Blood. 2006;108:3152–60.
Google Scholar
Put N, Konings P, Rack K, Jamar M, Roy NV, Libouton JM, et al. Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study. Genes, Chromosomes Cancer. 2009;48:843–53.
Google Scholar
Takashima T, Itoh M, Ueda Y, Nishida K, Tamaki T, Misawa S, et al. Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization. Int J Cancer. 1997;72:31–8.
Google Scholar
Fang H, Reichard KK, Rabe KG, Hanson CA, Call TG, Ding W, et al. IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes. Am J Hematol. 2019;94:338–45.
Google Scholar
Nguyen-Khac F, Chapiro E, Lesty C, Grelier A, Luquet I, Radford-Weiss I, et al. Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia. Am J Blood Res. 2011;1:13–21.
Google Scholar
Heerema NA, Muthusamy N, Zhao Q, Ruppert AS, Breidenbach H, Andritsos LA, et al. Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia. Haematologica. 2021;106:1608–15.
Google Scholar
Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia. 2007;21:1532–44.
Google Scholar
Giefing M, Siebert R. FISH and FICTION to detect chromosomal aberrations in lymphomas. Methods Mol Biol. 2013;971:227–44.
Google Scholar
Ventura RA, Martin-Subero JI, Jones M, McParland J, Gesk S, Mason DY, et al. FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissue. J Mol Diagn. 2006;8:141–51.
Google Scholar
Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, et al. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021;35:2002–16.
Google Scholar
Tausch E, Schneider C, Robrecht S, Zhang C, Dolnik A, Bloehdorn J, et al. Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax. Blood. 2020;135:2402–12.
Google Scholar
Knisbacher BA, Lin Z, Hahn CK, Nadeu F, Duran-Ferrer M, Stevenson KE, et al. Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genetics. 2022;54:1664–74.
Tausch E, Beck P, Schlenk RF, Jebaraj BJ, Dolnik A, Yosifov DY, et al. Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1. haematol. 2020;105:2440–7.
Google Scholar
Kröber A, Seiler T, Benner A, Bullinger L, Brückle E, Lichter P, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002;100:1410–6.
Google Scholar
Jaramillo S, Agathangelidis A, Schneider C, Bahlo J, Robrecht S, Tausch E, et al. Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG). haematol. 2020;105:2598–607.
Google Scholar
Massoni-Badosa R, Aguilar-Fernández S, Nieto JC, Soler-Vila P, Elosua-Bayes M, Marchese D, et al. An atlas of cells in the human tonsil. Immunity. 2024;57:379–99.e18.
Google Scholar
Rossi D, Gaidano G. Biological and clinical significance of stereotyped B-cell receptors in chronic lymphocytic leukemia. haematol. 2010;95:1992–5.
Google Scholar
Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D. Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016;10:18.
Google Scholar
Asirvatham JR, Brody J, Vora R, Kolitz JE, Fields SZ, Sreekantaiah C, et al. Prognostic significance of isolated t(8:14) in chronic lymphocytic leukemia. Leuk Lymphoma. 2014;55:685–8.
Google Scholar
Huh YO, Lin KIC, Vega F, Schlette E, Yin CC, Keating MJ, et al. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Br J Haematol. 2008;142:36–44.
Google Scholar
Put N, Van Roosbroeck K, Konings P, Meeus P, Brusselmans C, Rack K, et al. Chronic lymphocytic leukemia and prolymphocytic leukemia with MYC translocations: a subgroup with an aggressive disease course. Ann Hematol. 2012;91:863–73.
Google Scholar
Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, et al. Class-switch recombination occurs infrequently in germinal centers. Immunity. 2019;51:337–50.e7.
Google Scholar
Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, et al. Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. Leukemia. 2002;16:937–9.
Google Scholar
Küppers R. Distinct t(14;19) translocation patterns in atypical chronic lymphocytic leukemia and marginal zone lymphomas. Haematologica. 2024;109:376–8.
Google Scholar
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848–54.
Google Scholar
Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102:1515–25.
Google Scholar
Schroeder HWJ, Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today. 1994;15:288–94.
Google Scholar
Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840–7.
Google Scholar
Geller MD, Pei Y, Spurgeon SE, Durum C, Leeborg NJ. Chronic lymphocytic leukemia with a FGFR3 translocation: case report and literature review of an uncommon cytogenetic event. Cancer Genet. 2014;207:340–3.
Google Scholar
Bacher U, Haferlach T, Schnittger S, Weiss T, Burkhard O, Bechtel B, et al. Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2010;200:170–4.
Google Scholar
Socola F, Insuasti-Beltran G, Henrich Lobo R, Atrash S, Sasapu A. Chronic lymphocytic leukemia with translocation (2;14)(p16;q32): a case report and review of the literature. Case Rep Oncol Med. 2016;2016:9037436.
Google Scholar
Malli T, Rammer M, Haslinger S, Burghofer J, Burgstaller S, Boesmueller HC, et al. Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3). Mol Cytogenet. 2018;11:3.
Google Scholar
Rouhigharabaei L, Ferreiro JF, Put N, Michaux L, Tousseyn T, Lefebvre C, et al. BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma. Genes Chromosomes Cancer. 2013;52:928–44.
Google Scholar
Hayette S, Tigaud I, Callet-Bauchu E, Ffrench M, Gazzo S, Wahbi K, et al. In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene. Blood. 2003;102:1549–50.
Google Scholar
Offit K, Parsa NZ, Filippa D, Jhanwar SC, Chaganti RS. t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin’s lymphoma with plasmacytoid differentiation. Blood. 1992;80:2594–9.
Google Scholar
Finn WG, Kay NE, Kroft SH, Church S, Peterson LC. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol. 1998;59:223–9.
Google Scholar
Dascalescu CM, Péoc’h M, Callanan M, Jacob MC, Sotto MF, Gressin R, et al. Deletion 7q in B-cell low-grade lymphoid malignancies: a cytogenetic/fluorescence in situ hybridization and immunopathologic study. Cancer Genet Cytogenet. 1999;109:21–8.
Google Scholar
Gailllard B, Cornillet-Lefebvre P, Le QH, Maloum K, Pannetier M, Lecoq-Lafon C, et al. Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities. Br J Haematol. 2021;193:72–82.
Google Scholar
Walker BA, Wardell CP, Johnson DC, Kaiser MF, Begum DB, Dahir NB, et al. Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells. Blood. 2013;121:3413–9.
Google Scholar
Sonoki T, Harder L, Horsman DE, Karran L, Taniguchi I, Willis TG, et al. Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood. 2001;98:2837–44.
Google Scholar
Ruminy P, Jardin F, Picquenot JM, Gaulard P, Parmentier F, Buchonnet G, et al. Histology of lymphomas with t(3;14)(q27;q32) correlates with the molecular anatomy of the translocation. Blood. 2005;106:1906
Google Scholar
Ueda Y, Nishida K, Miki T, Horiike S, Kaneko H, Yokota S, et al. Interphase detection of BCL6/IgH fusion gene in non-Hodgkin lymphoma by fluorescence in situ hybridization. Cancer Genet Cytogenet. 1997;99:102–7.
Google Scholar
Nagoshi H, Taki T, Hanamura I, Nitta M, Otsuki T, Nishida K, et al. Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality. Cancer Res. 2012;72:4954–62.
Google Scholar
Mikulasova A, Ashby C, Tytarenko RG, Qu P, Rosenthal A, Dent JA, et al. Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma. Haematologica. 2020;105:1055–66.
Google Scholar
Auer RL, Starczynski J, McElwaine S, Bertoni F, Newland AC, Fegan CD, et al. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2005;43:1–10.
Google Scholar
Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, et al. Genetic variation associated with longer telomere length increases risk of chronic lymphocytic leukemia. Cancer Epidemiol Biomark Prev. 2016;25:1043–9.
Google Scholar
Ma D, Chen Z, Patel KP, Mishra BM, Yao H, Abruzzo LV, et al. Array comparative genomic hybridization analysis identifies recurrent gain of chromosome 2p25.3 involving the ACP1 and MYCN genes in chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk. 2011;11:S17–24.
Google Scholar
Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000;275:10315–22.
Google Scholar
Simon R, Wiegreffe C, Britsch S. Bcl11 transcription factors regulate cortical development and function. Front Mol Neurosci. 2020;13:51.
Google Scholar
Cavazzini F, Hernandez JA, Gozzetti A, Russo Rossi A, Angeli C, Tiseo R, et al. Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis. Br J Haematol. 2008;142:529–37.
Google Scholar
Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, et al. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Blood. 2001;98:3413–20.
Google Scholar
Yin CC, Lin KIC, Ketterling RP, Knudson RA, Medeiros LJ, Barron LL, et al. Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes. Am J Clin Pathol. 2009;131:663–70.
Google Scholar
Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M. COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. Biochem J. 2002;368:555–63.
Google Scholar
Yin J, Xie X, Ye Y, Wang L, Che F. BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases. Biosci Rep. 2019;39. https://doi.org/10.1042/BSR20190604.
Tanaka M, Yamasaki N, Izumo S. Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol Cell Biol. 2000;20:2874–9.
Google Scholar
Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, et al. Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3′-BCL11B enhancers and coregulation by PU.1 and HMGA1. Cancer Res. 2007;67:1461–71.
Google Scholar
Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, et al. Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. Nat Commun. 2016;7:11889.
Google Scholar
Beekman R, Chapaprieta V, Russiñol N, Vilarrasa-Blasi R, Verdaguer-Dot N, Martens JHA, et al. The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia. Nat Med. 2018;24:868–80.
Google Scholar
Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gérard D, et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med. 2010;207:2141–56.
Google Scholar
Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009;10:147–56.
Google Scholar
Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Dürig J, et al. Cellular origin and pathophysiology of chronic lymphocytic leukemia. J Exp Med. 2012;209:2183–98.
Google Scholar
Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell. 2011;20:246–59.
Google Scholar
Alizadeh AA, Majeti R. Surprise! HSC are aberrant in chronic lymphocytic leukemia. Cancer Cell. 2011;20:135–6.
Google Scholar
Jackson CM, Pant A, Dinalankara W, Choi J, Jain A, Nitta R, et al. The cytokine Meteorin-like inhibits anti-tumor CD8(+) T cell responses by disrupting mitochondrial function. Immunity. 2024;57:1864–77.e9.
Google Scholar
