Laskowski, T. J., Biederstadt, A. & Rezvani, K. Natural killer cells in antitumour adoptive cell immunotherapy. Nat. Rev. Cancer 22, 557–575 (2022).
Google Scholar
Liu, S. et al. NK cell-based cancer immunotherapy: from basic biology to clinical development. J. Hematol. Oncol. 14, 7 (2021).
Google Scholar
Huang, L., Zhu, P., Xia, P. & Fan, Z. WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation. Cell Death Dis. 7, e2301 (2016).
Google Scholar
Kreusser, L. M. & Rendall, A. D. Autophosphorylation and the dynamics of the activation of Lck. Bull. Math. Biol. 83, 64 (2021).
Google Scholar
Levental, I. & Lyman, E. Regulation of membrane protein structure and function by their lipid nano-environment. Nat. Rev. Mol. Cell Biol. 24, 107–122 (2023).
Google Scholar
Bharti, R., Dey, G., Lin, F., Lathia, J. & Reizes, O. CD55 in cancer: complementing functions in a non-canonical manner. Cancer Lett. 551, 215935 (2022).
Google Scholar
Dean, I. et al. Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity. Nat. Commun. 15, 683 (2024).
Google Scholar
Heras-Murillo, I., Adan-Barrientos, I., Galan, M., Wculek, S. K. & Sancho, D. Dendritic cells as orchestrators of anticancer immunity and immunotherapy. Nat. Rev. Clin. Oncol. 21, 257–277 (2024).
Google Scholar
Tang, F. et al. A pan-cancer single-cell panorama of human natural killer cells. Cell 186, 4235–4251.e20 (2023).
Google Scholar
Liu, Y. et al. Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution. Nat. Commun. 12, 741 (2021).
Google Scholar
Che, L. H. et al. A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy. Cell Discov. 7, 80 (2021).
Google Scholar
de Andrade, L. F. et al. Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight 4, e133103 (2019).
Google Scholar
Azizi, E. et al. Single-cell map of diverse immune phenotypes in the breast tumor microenvironment. Cell 174, 1293–1308.e36 (2018).
Google Scholar
Zhang, Y. et al. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell 39, 1578–1593.e8 (2021).
Kurten, C. H. L. et al. Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing. Nat. Commun. 12, 7338 (2021).
Google Scholar
Zilionis, R. et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity 50, 1317–1334.e10 (2019).
Google Scholar
Cillo, A. R. et al. Immune landscape of viral- and carcinogen-driven head and neck cancer. Immunity 52, 183–199.e9 (2020).
Zhang, Q. et al. Landscape and dynamics of single immune cells in hepatocellular carcinoma. Cell 179, 829–845.e20 (2019).
Google Scholar
Yuen, K. C. et al. High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nat. Med. 26, 693–698 (2020).
Google Scholar
Steele, N. G. et al. Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nat. Cancer 1, 1097–1112 (2020).
Google Scholar
Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell 181, 442–459.e29 (2020).
Google Scholar
Li, J. H. et al. MEF2C regulates NK cell effector functions through control of lipid metabolism. Nat. Immunol. 25, 778–789 (2024).
Google Scholar
Mastellos, D. C., Hajishengallis, G. & Lambris, J. D. A guide to complement biology, pathology and therapeutic opportunity. Nat. Rev. Immunol. 24, 118–141 (2024).
Google Scholar
Wolf, N. K., Kissiov, D. U. & Raulet, D. H. Roles of natural killer cells in immunity to cancer, and applications to immunotherapy. Nat. Rev. Immunol. 23, 90–105 (2023).
Google Scholar
Cone, J. C., Lu, Y., Trevillyan, J. M., Bjorndahl, J. M. & Phillips, C. A. Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells. Eur. J. Immunol. 23, 2488–2497 (1993).
Google Scholar
Saygin, C. et al. CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors. J. Exp. Med. 214, 2715–2732 (2017).
Google Scholar
Nagaraj, V. et al. Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion. Biochem Biophys. Res. Commun. 460, 518–524 (2015).
Google Scholar
Yin, Y. et al. CD97 promotes tumor aggressiveness through the traditional G protein-coupled receptor-mediated signaling in hepatocellular carcinoma. Hepatology 68, 1865–1878 (2018).
Google Scholar
Janes, P. W., Ley, S. C. & Magee, A. I. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147, 447–461 (1999).
Google Scholar
Fu, T. et al. Interferon-induced senescent CD8(+) T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer. Sci. Transl. Med. 17, eadj7808 (2025).
Google Scholar
Jerby-Arnon, L. et al. A cancer cell program promotes T cell exclusion and resistance to checkpoint blockade. Cell 175, 984–997.e24 (2018).
Google Scholar
Groh, V., Wu, J., Yee, C. & Spies, T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734–738 (2002).
Google Scholar
Ferrari de Andrade, L. et al. Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science 359, 1537–1542 (2018).
Google Scholar
Chan, J. M. et al. Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell 39, 1479–1496.e18 (2021).
Google Scholar
Sade-Feldman, M. et al. Defining T cell states associated with response to checkpoint immunotherapy in melanoma. Cell 175, 998–1013.e20 (2018).
Google Scholar
Finberg, R. W., White, W. & Nicholson-Weller, A. Decay-accelerating factor expression on either effector or target cells inhibits cytotoxicity by human natural killer cells. J. Immunol. 149, 2055–2060 (1992).
Google Scholar
DeZern, A. E. & Brodsky, R. A. Paroxysmal nocturnal hemoglobinuria: a complement-mediated hemolytic anemia. Hematol. Oncol. Clin. North Am. 29, 479–494 (2015).
Google Scholar
Ozen, A. et al. CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis. N. Engl. J. Med. 377, 52–61 (2017).
Google Scholar
Bharti, R. et al. Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer. Mol. Cancer 23, 121 (2024).
Google Scholar
Safaee, M. et al. CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review). Int. J. Oncol. 43, 1343–1350 (2013).
Google Scholar
Roybal, K. T. et al. Engineering T cells with customized therapeutic response programs using synthetic notch receptors. Cell 167, 419–432.e16 (2016).
Google Scholar

