Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834.
Google ScholarÂ
Bartelt S, Momm F, Weissenberger C, Lutterbach J. Patients with brain metastases from gastrointestinal tract cancer treated with whole brain radiation therapy: prognostic factors and survival. World J Gastroenterol. 2004;10:3345–8. https://doi.org/10.3748/wjg.v10.i22.3345.
Google ScholarÂ
Go PH, Klaassen Z, Meadows MC, Chamberlain RS. Gastrointestinal cancer and brain metastasis: A rare and ominous sign. Cancer. 2011;117:3630–40. https://doi.org/10.1002/cncr.25940.
Google ScholarÂ
Alkrekshi A, Elantably D, Hammad F, Al Armashi AR. Prevalence and survival of gastrointestinal malignancies with brain metastasis: Surveillance, Epidemiology, and End Results SEER database analysis 2010-2018. JCO. 2022;40:e14004–e14004. https://doi.org/10.1200/JCO.2022.40.16_suppl.e14004.
Google ScholarÂ
Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, et al. Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient. JCO. 2020;38:3773–84. https://doi.org/10.1200/JCO.20.01255.
Google ScholarÂ
Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 2012;30:419–25. https://doi.org/10.1200/JCO.2011.38.0527.
Google ScholarÂ
Sperduto PW, Fang P, Li J, Breen W, Brown PD, Cagney D, et al. Estimating survival in patients with gastrointestinal cancers and brain metastases: An update of the graded prognostic assessment for gastrointestinal cancers (GI-GPA). Clin Transl Radiat Oncol. 2019;18:39–45. https://doi.org/10.1016/j.ctro.2019.06.007.
Google ScholarÂ
Lemke J, Scheele J, Kapapa T, Wirtz CR, Henne-Bruns D, Kornmann M. Brain metastasis in pancreatic cancer. Int J Mol Sci. 2013;14:4163–73. https://doi.org/10.3390/ijms14024163.
Google ScholarÂ
Stavrinou P, Plambeck L, Proescholdt M, Ghadimi M, Goldbrunner R, Grau S. Brain metastases from esophageal cancer: A retrospective analysis of the outcome after surgical resection followed by radiotherapy. Med (Baltim). 2019;98:e16653. https://doi.org/10.1097/MD.0000000000016653.
Google ScholarÂ
Huang L, Wang L, Shi Y, Zhao Y, Xu C, Zhang J, et al. Brain metastasis from gastric adenocarcinoma: A large comprehensive population-based cohort study on risk factors and prognosis. Front Oncol. 2022;12:897681. https://doi.org/10.3389/fonc.2022.897681.
Google ScholarÂ
Müller S, Köhler F, Hendricks A, Kastner C, Börner K, Diers J, et al. Brain Metastases from Colorectal Cancer: A Systematic Review of the Literature and Meta-Analysis to Establish a Guideline for Daily Treatment. Cancers (Basel). 2021;13:900. https://doi.org/10.3390/cancers13040900.
Google ScholarÂ
Wang S, Wang A, Lin J, Xie Y, Wu L, Huang H, et al. Brain metastases from hepatocellular carcinoma: recent advances and future avenues. Oncotarget. 2017;8:25814–29. https://doi.org/10.18632/oncotarget.15730.
Google ScholarÂ
D’Andrea MR, Gill CM, Umphlett M, Tsankova NM, Fowkes M, Bederson JB, et al. Brain Metastases from Biliary Tract Cancers: A Case Series and Review of the Literature in the Genomic Era. Oncologist. 2020;25:447–53. https://doi.org/10.1634/theoncologist.2019-0306.
Google ScholarÂ
Hernando-Cubero J, Alonso-Orduña V, Hernandez-Garcia A, DE Miguel AC, Alvarez-Garcia N, Anton-Torres A. Brain metastasis in basaloid undifferentiated anal carcinoma: A case report. Oncol Lett. 2014;7:1276–8. https://doi.org/10.3892/ol.2014.1845.
Google ScholarÂ
Rughani AI, Lin C, Tranmer BI, Wilson JT. Anal cancer with cerebral metastasis: a case report. J Neurooncol. 2011;101:141–3. https://doi.org/10.1007/s11060-010-0218-5.
Google ScholarÂ
Collins GS, Reitsma JB, Altman DG, Moons K. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement. BMC Med. 2015;13:1. https://doi.org/10.1186/s12916-014-0241-z.
Google ScholarÂ
Mandrekar JN. Receiver Operating Characteristic Curve in Diagnostic Test Assessment. J Thorac Oncol. 2010;5:1315–6. https://doi.org/10.1097/JTO.0b013e3181ec173d.
Google ScholarÂ
Gabrielsen TO, Eldevik OP, Orringer MB, Marshall BL. Esophageal carcinoma metastatic to the brain: clinical value and cost-effectiveness of routine enhanced head CT before esophagectomy. AJNR Am J Neuroradiol. 1995;16:1915–21.
Google ScholarÂ
Weinberg JS, Suki D, Hanbali F, Cohen ZR, Lenzi R, Sawaya R. Metastasis of esophageal carcinoma to the brain. Cancer. 2003;98:1925–33. https://doi.org/10.1002/cncr.11737.
Google ScholarÂ
Tincknell G, Naveed A, Nankervis J, Mukhtiar A, Piper A-K, Becker TM, et al. HER2-Positive Gastroesophageal Cancers Are Associated with a Higher Risk of Brain Metastasis. Cancers (Basel). 2022;14:5754. https://doi.org/10.3390/cancers14235754.
Google ScholarÂ
Liang K, Feliciano JL, Marrone KA, Murray JC, Hann CL, Anagnostou V, et al. Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis. ESMO Open. 2024;9:102199. https://doi.org/10.1016/j.esmoop.2023.102199.
Google ScholarÂ
Cascino TL, Leavengood JM, Kemeny N, Posner JB. Brain metastases from colon cancer. J Neurooncol. 1983;1:203–9. https://doi.org/10.1007/BF00165604.
Google ScholarÂ
Hammoud MA, McCutcheon IE, Elsouki R, Schoppa D, Patt YZ. Colorectal carcinoma and brain metastasis: distribution, treatment, and survival. Ann Surg Oncol. 1996;3:453–63. https://doi.org/10.1007/BF02305763.
Google ScholarÂ
Rehman MEU, Kulsoom A, Faraz F, Mustafa B, Shahid A, Cheema HA, et al. Analysis of risk factors and prognostic factors of brain metastasis in gastric cancer: a surveillance, epidemiology and end-results database study. Sci Rep. 2023;13:18664. https://doi.org/10.1038/s41598-023-46109-9.
Google ScholarÂ
Zhang L, Yu Z, Zhang Y, Wang H, Cheng J, Shi C. A Nomogram Based on Clinicopathological Characteristics for Estimating the Risk of Brain Metastasis from Advanced Gastric Cancer: A Multi-Center Retrospective Clinical Study. TCRM. 2024;20:391–404. https://doi.org/10.2147/TCRM.S460647.
Google ScholarÂ
Seinfeld J, Wagner AS, Kleinschmidt-DeMasters BK. Brain Metastases from Hepatocellular Carcinoma in US Patients. J Neurooncol. 2006;76:93–8. https://doi.org/10.1007/s11060-005-4175-3.
Google ScholarÂ
Mongan JP, Fadul CE, Cole BF, Zaki BI, Suriawinata AA, Ripple GH, et al. Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines. Clin Colorectal Cancer. 2009;8:100–5.
Google ScholarÂ
Majd N, Simon M, Wagman R, Gesner L. A rare case of colon cancer metastasis to the brain and a brief review of its treatment and prognosis. Radiol Case Rep. 2022;17:696–9. https://doi.org/10.1016/j.radcr.2021.11.047.
Google ScholarÂ
Marcucci F, Corti A, Ferreri AJM. Breaching the Blood–Brain Tumor Barrier for Tumor Therapy. Cancers. 2021;13:2391. https://doi.org/10.3390/cancers13102391.
Google ScholarÂ
Steindl A, Brunner TJ, Heimbach K, Schweighart K, Moser GM, Niziolek HM, et al. Changing characteristics, treatment approaches and survival of patients with brain metastasis: data from six thousand and thirty-one individuals over an observation period of 30 years. Eur J Cancer. 2022;162:170–81. https://doi.org/10.1016/j.ejca.2021.12.005.
Google ScholarÂ
Sharma P, Miller T, Mahadevia H, Fatima I, Sharma P, Cheng A-L, et al. Trends in survival in solid malignancies with synchronous brain metastases: A population-based study. JCO. 2024;42:e23299–e23299. https://doi.org/10.1200/JCO.2024.42.16_suppl.e23299.
Google ScholarÂ
Ishizuka Y, Omori T, Shinno N, Yamamoto M, Hara H, Otsuka T, et al. Early detection of brain metastases and appropriate local therapy followed by systemic chemotherapy may improve the prognosis of gastric cancer. Sci Rep. 2023;13:20805. https://doi.org/10.1038/s41598-023-46933-z.
Google ScholarÂ
Yap W-K, Shih M-C, Kuo C, Pai P-C, Chou W-C, Chang K-P, et al. Development and Validation of a Nomogram for Assessing Survival in Patients With Metastatic Lung Cancer Referred for Radiotherapy for Bone Metastases. JAMA Netw Open. 2018;1:e183242. https://doi.org/10.1001/jamanetworkopen.2018.3242.
Google ScholarÂ
Tsai C, Nguyen B, Luthra A, Chou JF, Feder L, Tang LH, et al. Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma. JAMA Netw Open. 2022;5:e2228083 https://doi.org/10.1001/jamanetworkopen.2022.28083.
Google ScholarÂ
Bekki S, Hashimoto S, Yamasaki K, Komori A, Abiru S, Nagaoka S, et al. Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma. PLoS ONE. 2020;15:e0241002. https://doi.org/10.1371/journal.pone.0241002.
Google ScholarÂ
Beylerli O, Shi H, Begliarzade S, Shumadalova A, Ilyasova T, Sufianov A. MiRNAs as new potential biomarkers and therapeutic targets in brain metastasis. Non-Coding RNA Res. 2024;9:678–86. https://doi.org/10.1016/j.ncrna.2024.02.014.
Google ScholarÂ
Arner EN, Alzhanova D, Westcott JM, Hinz S, Tiron CE, Blø M, et al. AXL-TBK1 driven AKT3 activation promotes metastasis. Sci Signal. 2024;17:eado6057. https://doi.org/10.1126/scisignal.ado6057.
Google ScholarÂ
Christensen TD, Spindler K-LG, Palshof JA, Nielsen DL. Systematic review: brain metastases from colorectal cancer-Incidence and patient characteristics. BMC Cancer. 2016;16:260. https://doi.org/10.1186/s12885-016-2290-5.
Google ScholarÂ
Callesen LB, Boysen AK, Andersen RF, Dalby RB, Spindler K-LG. Circulating DNA and frequency of colorectal cancer brain metastases in a presumed high-risk group. Sci Rep. 2023;13:18574. https://doi.org/10.1038/s41598-023-45939-x.
Google ScholarÂ

