Rui-Xue H, Ping-Kun Z. DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transd Target Ther. 2020;5:60.
Google Scholar
Liuyun G, Yujie Z, Chengcheng L, Mingzhen Z, Suxia H. Application of Radiosensitizers in Cancer Radiotherapy. Int J Nanomed. 2021;16:8139–8139.
Google Scholar
Tatsuya S, Minoru K, Jin-Min N, Hiroshi H. Tumor microenvironment and radioresistance. Exp Mol Med. 2021;53:1029–35.
Google Scholar
Xianzhe Y, Lingling Z, Ting W, Lu L, Jiewei L, Guowei C, et al. Enhancing the anti-tumor response by combining DNA damage repair inhibitors in the treatment of solid tumors. Biochimica et Biophysica acta. 2023;1878:188910.
Somnath G, Anu G. Activation of DNA damage response signaling in mammalian cells by ionizing radiation. Free Radic Res. 2021;55:581–94.
Wil LS, Fen X. Ionizing radiation-induced DNA damage, response, and repair. Antioxid Redox Signal. 2014;21:251–9.
Google Scholar
Michael RL. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010;79:181–211.
Google Scholar
Xuan L, Wolf-Dietrich H. Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 2008;18:99–113.
Google Scholar
Ambber W, Kum KK, Adrian PW. Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51. Cancer Treat Rev. 2015;41:35–45.
Google Scholar
Hui D, Wei L, Cheng-Kang Z, Hui X, Gang F, Wei-Rong J, et al. Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene. Gene. 2001;264:187–96.
Google Scholar
Chao-Pei L, Zhenyu Y, Jun X, Jie H, Aoqun S, Dongbo D, et al. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science. 2023;381:eadd8673.
Google Scholar
Sihem C, Ulrich E, Barbara H, Youngsook L, Jernej M, Maria N, et al. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015;528:218.
Google Scholar
Chunying Y, Shiladitya S, Pavana M, Joy M, Shuai J, Brooke H, et al. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic Acids Res. 2017;45:739–48.
Google Scholar
Ting-Hsiang H, Faith F, Chin-Chuan C, Zih-Jie S, Barry S, Jessica K. The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. Mol Cell. 2018;69:879–92.
Google Scholar
Tanay T, Ashna D, Joshua S, Emily M, Claudia M, George-Lucian M. Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling. Nat Commun. 2022;13:5323.
Google Scholar
Albert S, Zhiguo Z. Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity. Trends Biochem Sci. 2018;43:136–48.
Google Scholar
Feng X, Qi X, Bin C, Ruru W, Jie Z, Xipeng Z, et al. ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity. Cell Death Differ. 2025;32:1303–16.
Google Scholar
Jie Z, Bin C, Feng X, Ruru W, Xipeng Z, Zhicheng Y, et al. Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance. Oncogene. 2025;44:1106–17.
Google Scholar
Jiao Z, Shanshan T, Qiushi G, Kaiwen B, Guohui Y, Xiaodan W, et al. A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination. Mol Cell. 2022;82:2571–2587.e9.
Google Scholar
Yan Z, Xinping H, Dan Z, Min W, Jiechen L, Shuyu Y, et al. Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Cell Death Differ. 2022;29:2531–44.
Google Scholar
Ruru W, Yajing S, Bin C, Feng X, Jie Z, Zhaoyang Z, et al. Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity. Cell Death Dis. 2022;13:851.
Google Scholar
Zhicheng Y, Ruru W, Bin C, Xipeng Z, Jie Z, Shenglan Z, et al. RNF185 orchestrates replication fork restart and homologous recombination through temporal RPA1 ubiquitination switching. Cancer Lett. 2026;650:218513. 10.
Google Scholar
Joshua EL, Tom EF, David AB, Cristina MF, Melissa LK. Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors. Cell Syst. 2021;12:68–81.e11.
Google Scholar
Jean-Pierre Q, Annabelle G, Adam JLC, Danièle R, Geneviève A. The HP1-p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells. Nat Struct Mol Biol. 2008;15:972–9.
Google Scholar
Tiffany JY, Yi C, Joseph I, Ann LK. Modulation of Gene Silencing by Cdc7p via H4 K16 Acetylation and Phosphorylation of Chromatin Assembly Factor CAF-1 in Saccharomyces cerevisiae. Genetics. 2019;211:1219–37.
Google Scholar
Hengxing C, Yun L, Huafu L, Xiancong C, Huafeng F, Deli M, et al. NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature. 2024;631:663–9.
Google Scholar
Elizabeth S, Kayla MC, Cheryl JS, Mary JM, Maria D, Jeffrey B, et al. MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress. Cancer Res. 2017;77:5327–38.
Google Scholar
Tanzhen L, Jingjing W, Chao J, Chen W, Xiaoqin Z, Yan D, et al. CHAF1A, the largest subunit of the chromatin assembly factor 1 complex, regulates the growth of H1299 human non-small cell lung cancer cells by inducing G0/G1 cell cycle arrest. Exp Ther Med. 2017;14:4681–6.
Michele O, Tiffany C, Alejandro Á, Kejiao L, Matthew JS, Michal Z, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. 2020;182:1–16.
Amogh G, Nick R, Sara L, Caleb H, Michael JO, Normand C, et al. Unorthodox PCNA Binding by Chromatin Assembly Factor 1. Int J Mol Sci. 2022;23:11099.
Google Scholar
Jakob T, Simon T, Shuyao S, Franziska G, Sandra G, Susanne IW, et al. The human proteome with direct physical access to DNA. Cell. 2025;188:1–17.
Bing W, Hai-Xiang Z, Jing-Hua H, Qian T, Dan-Xia D, Zhi-Da Z, et al. Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells. Cell Death Dis. 2025;6:147.
Kuo Z, Yuan G, Jingjing L, Rebecca B, Junhong H, Huanhuan L, et al. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks. Nucleic Acids Res. 2016;44:5083–94.
Google Scholar
Bing W, Dan-Xia D, Lian-Di L, Zhi-Da Z, Ya-Qi Z, Ke D, et al. Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer. Biomedicines. 2023;11:1184.
Google Scholar
Ou D, Thales N, Bin F, Eric AW, Rachael HM, Erin MG, et al. MSH6 modulates PARP inhibitor sensitivity in BRCA-proficient high-grade serous ovarian cancer. Cancer Res. 8S1:1872. 2025.
For-Fan C, Vincent Wai-Hin Y, Jialing S, Don Wai-Ching C, Cheuk-Ting L, Bowie Po-Yee W, et al. Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity of hepatocellular carcinoma. Hepatology. 2024;80:295–311.
Google Scholar
Xia S, Qiushuang M, Yahong C, Huangwei H, Jing Q, Mengchen Z, et al. Overexpression of CHAF1A is associated with poor prognosis, tumor immunosuppressive microenvironment and treatment resistance. Front Genet. 2023;14:1108004.
Google Scholar

