Sebastien A, Jacques F, Isabelle S, Ariana Z, Ahmedin J, Freddie B. Bladder Cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2016;71:96–108.
Thomas WF, Philippe ES, Neeraj A, Rick B, Stephen AB, Mark KB, et al. Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020;18:329–54.
Prashant M, David CC. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat Rev Mol Cell Biol. 2014;15:634–46.
Google Scholar
J Alfred W, Harman Max B, Richard C, Eva MC, Nigel CC, Georgios G, et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. Eur Urol. 2020;79:82–104.
Marc L, Orian SS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 2013;17:491–506.
Google Scholar
Hsiuchen C, David CC. Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells. Cell Metab. 2017;26:39–48.
Google Scholar
Wei Shen T, John DK. Intravesical device-assisted therapies for non-muscle-invasive bladder cancer. Nat Rev Urol. 2018;15:667–85.
Google Scholar
Raymond HM, Daniel H, William US, Jason AE, William JT, Michael PH, et al. Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233. J Clin Oncol. 2014;32:3801–9.
Google Scholar
Vijay ACR, Satish BM, Ben RG, Noel WC. Differential complication rates following radical cystectomy in the irradiated and nonirradiated pelvis. Eur Urol. 2009;57:1058–63.
May T. Addressing challenges in low-income and middle-income countries through novel radiotherapy research opportunities. Lancet Oncol. 2024;25:1509–11.
Google Scholar
Alberto C, Stephen JE. The DNA damage response: making it safe to play with knives. Mol Cell. 2010;40:179–204.
Google Scholar
Jianli M, Junwen Z, Jingtong L, Ji L, Xiaofeng K, Jinming Y. Enhanced E6AP-mediated ubiquitination of ENO1 via LINC00663 contributes to radiosensitivity of breast cancer by regulating mitochondrial homeostasis. Cancer Lett. 2023;560:216118.
Google Scholar
Pallas K, Andrew JT, Xuexia L, Stephanie DT, Zhenhui Z, Ian RH, et al. Histone variant H2A.W7 represses meiotic crossover formation in Arabidopsis heterochromatin. Proc Natl Acad Sci USA 2025;122:e2414166122.
Google Scholar
Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, et al. Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat Cell Biol. 2014;16:1016–26.
Google Scholar
Jeffrey AH, Jia L, Purnima R, Jun Y, Ann C, Albert X, et al. Mapping the genetic landscape of DNA double-strand break repair. Cell. 2021;184:5653–69.e25.
Google Scholar
Petra S, Simon B-J, Niels M. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. Nat Rev Mol Cell Biol. 2016;17:379–94.
Google Scholar
Mingjing H, Zhuan Z, Anil AS, Haojing Z, Jin T, Qianming C, et al. The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics. Cell Biosci. 2016;6:62.
Google Scholar
Jingjie Y, Huan L, Bo C, Ning K, Xiaoping H, Jianping H, et al. Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1. Cell Death Differ. 2023;30:1799–810.
Google Scholar
Junko M, Kailin Y, Donniphat D, Kouji H, Shunichi T, Alan DDA. The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol. 2011;31:2462–9.
Google Scholar
Jae Jin K, Seo Yun L, Yiseul H, Soyeon K, Jee Min C, Sangwook P, et al. USP39 promotes non-homologous end-joining repair by poly (ADP-ribose)-induced liquid demixing. Nucleic Acids Res. 2021;49:11083–102.
Google Scholar
Xiang C, Zhenyu Y, Chengxian M, Peng X, Wenyue S, Yizhi G, et al. USP49 undergoes liquid-liquid phase separation and stabilizes RPA70 to induce radioresistance through homologous recombination repair in esophageal squamous cell carcinoma. Int J Biol Macromol. 2025;318:144834.
Google Scholar
Yihan P, Qingchao L, Wei T, Changmin P, Zhaohua H, Yali C, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224.
Google Scholar
Mauricio C-S, Rodrigo F-V, Hermann Z-F, Jennifer R. Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism. Metabolism. 2023;144:155578.
Google Scholar
Rubén Q-C, Luca S. Determinants and outcomes of mitochondrial dynamics. Mol Cell. 2023;83:857–76.
Google Scholar
Lena P, Luca S. Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function. Annu Rev Physiol. 2015;78:505–31.
Chan DC. Mitochondrial Dynamics and Its Involvement in Disease. Annu Rev Pathol. 2020;15:235–59.
Google Scholar
Keun Woo R, Tak Shun F, Daphne CB, Michelle S, Jinsung P, Christopher AF-A, et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature. 2024;635:746–54.
Google Scholar
Yu Z, Shengjie J, Xiaoling D, An L, Xiaolin H, Yun X, et al. Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle. Sci Adv. 2024;10:eadl0372.
Google Scholar
Ahmed ST, Craven L, Russell OM, Turnbull DM, Vincent AE. Diagnosis and Treatment of Mitochondrial Myopathies. Neurotherapeutics. 2018;15:943–53.
Google Scholar
Ting W, Fangzhou S, Chunxiao L, Peng N, Yan S, Xuhao W, et al. MTA1, a Novel ATP Synthase Complex Modulator, Enhances Colon Cancer Liver Metastasis by Driving Mitochondrial Metabolism Reprogramming. Adv Sci. 2023;10:e2300756.
Google Scholar
Matthew GVH, Lewis CC, Craig BT. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029–33.
Google Scholar
Chao S, Xiongxiong L, Bing W, Zhenhua W, Yang L, Cuixia D, et al. Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity. Theranostics. 2019;9:3595–607.
Google Scholar
Zheqiong T, Lanbo X, Min T, Fang B, Jiangjiang L, Liling L, et al. Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy. Theranostics. 2018;8:2329–47.
Google Scholar
Zaigang Z, Xin J, Lei Y, Cheng L, Haoxiang W, Wei X, et al. Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced-Pulmonary Fibrosis. Adv Sci. 2024;11:e2401394.
Google Scholar
Lu-Xin L, Jing-Hua H, Dan-Xia D, Hui Z, Zhen-Yuan Z, Lian-Di L, et al. Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer. Mol Cell Proteomics. 2023;22:100551.
Google Scholar
Han S, Faiqa M, Shiyong M, Xingyu W, Sandy N, Neha B, et al. Inhibition of mitochondrial bioenergetics and hypoxia to radiosensitize diffuse intrinsic pontine glioma. Neuro Oncol. 2024;27:1061–75.
Yuli B, Maria SKS, Charles LH, Jason AM. Fis1 regulates mitochondrial morphology, bioenergetics and removal of mitochondrial DNA damage in irradiated glioblastoma cells. J Cell Sci. 2024;138:jcs263459.
Yanni Z, Dan L, Ying Z, Shengfu L, Yan L, Lin W, et al. Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation. Cell Death Dis. 2022;13:689.
Google Scholar
Xiaodong L, Jingjing T, Yuze S, Chengrong G, Shizhou D, Xiyu C, et al. Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling. J Exp Clin Cancer Res. 2024;43:273.
Google Scholar
Xiaofei Z, Yuanqing J, Yuewen W, Linge F, Yunhui Z, Yefeng C, et al. Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. Circ Res. 2023;133:508–31.
Google Scholar
Kang X, Jiayu G, Bo Y, Tianyu W, Qiangmin Q, Qi C, et al. Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion. Free Radic Biol Med. 2023;210:378–89.
Xiangyu C, Tong Y, Yue Z, Zhigang M, Wenli Z. Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury. CNS Neurosci Ther. 2024;30:e14725.
Google Scholar
Alice Z, Laura M, Juwei J, Katie NM, Callum GJ, Hannah G, et al. SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia. Cell Death Dis. 2024;15:881.
Google Scholar
Yan Y, Xiao-Dan P, Xiao-Jun Q, Kai-Ming Z, Xiang H, Yu-Hong C, et al. Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis. Signal Transd Target Ther. 2021;6:401.
Google Scholar
Haitham MA, Fahad NA. Development of a SYBR Green I based real-time RT-PCR assay for detection and quantification of bovine coronavirus. Mol Cell Probes. 2011;25:101–7.
Google Scholar
Jiani Y, Yuanyu L, Bojun W, Luying C, Xuefan Y, Feng W, et al. EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail. Cancer Lett. 2023;577:216427.
Google Scholar
Sergei IS, Michael BC. An enhanced antigen-retrieval protocol for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues. Methods Mol Biol. 2011;717:101–10.
Google Scholar
Wei A, Feng H, Jia XM, Tang H, Liao YY, Li BR, et al. Salvianolic acid B renders glioma cells more sensitive to radiation via Fis-1-mediated mitochondrial dysfunction. Biomed Pharmacother. 2018;107:1418–25.
Google Scholar
Minczuk M, He J, Duch AM, Ettema TJ, Chlebowski A, Dzionek K, et al. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res. 2011;39:4284–99.
Google Scholar
Yu Y, Yu J, Ge S, Su Y, Fan X. Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy. Int J Biol Sci. 2023;19:811–28.
Google Scholar
Xiuxiu Q, Ao W, Jiahui W, Zhanxia Z, Li T. Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions. Cell Death Discov. 2025;11:375.
Google Scholar
Nolden KA, Harwig MC, Hill RB. Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission. J Biol Chem. 2023;299:105380.
Google Scholar
Ihenacho UK, Toro R, Mansour RH, Hill RB. A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission. J Biol Chem. 2023;299:105303.
Google Scholar
Song F, Wei-Xiong C, Xiao-Bin L, Qiong-Lan T, Li-Juan S, Bo-Du L, et al. miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. Cancer Lett. 2015;362:183–91.
Google Scholar

