Friday, July 31

Browsing: Ubiquitination

Research

DTX3 promotes anti-tumor immunity by inducing PD-L1 ubiquitination and is suppressed by p65/miR-222 in bladder cancer

By NewsCancerJuly 24, 20260

Lee D, Cho M, Kim E, Seo Y, Cha JH. PD-L1: From cancer immunotherapy to therapeutic implications in multiple disorders.…

Research

Matrix stiffness drives HCC invasion and metastasis via interfering with TRIM21-mediated SCD1 ubiquitination

By NewsCancerJuly 1, 20260

Gargalionis AN, Papavassiliou KA, Papavassiliou AG. Mechanobiology of solid tumors. Biochim Biophys Acta Mol Basis Dis. 2022;1868:166555.Article CAS PubMed Google…

Research

Hypoxia-induced MIC19 myristoylation promotes PRKN-dependent VDAC2 ubiquitination and activates mitophagy in non-small cell lung cancer

By NewsCancerJune 20, 20260

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.PubMed Google Scholar Kasper S, Sebastian M.…

Research

SPOP-mediated K27-linked non-degradative ubiquitination of KCNN3 suppressing HCC progression via the CTCF-SATB1 axis

By NewsCancerMay 10, 20260

The metastasis of hepatocellular carcinoma (HCC) cells remains a major obstacle to achieving favorable clinical outcomes, yet the underlying molecular…

Research

Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination

By NewsCancerMarch 24, 20260

Pouyan A, Ghorbanlo M, Eslami M, Jahanshahi M, Ziaei E, Salami A, et al. Glioblastoma multiforme: insights into pathogenesis, key…

Research

Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation

By NewsCancerMarch 14, 20260

MEIS1 protein stability is regulated by E3 ubiquitin ligase MDM2By analyzing MEIS1 mRNA and protein levels in tumor and paired…

What's Hot

Patient cell drug profiling identifies p53-linked vulnerabilities in refractory lymphoid malignancies

OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer

Atezolizumab Plus Chemotherapy Improves PFS in dMMR/MSI-H Metastatic CRC

Browsing: Ubiquitination

DTX3 promotes anti-tumor immunity by inducing PD-L1 ubiquitination and is suppressed by p65/miR-222 in bladder cancer

Matrix stiffness drives HCC invasion and metastasis via interfering with TRIM21-mediated SCD1 ubiquitination

Hypoxia-induced MIC19 myristoylation promotes PRKN-dependent VDAC2 ubiquitination and activates mitophagy in non-small cell lung cancer

SPOP-mediated K27-linked non-degradative ubiquitination of KCNN3 suppressing HCC progression via the CTCF-SATB1 axis

Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination

Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation

Patient cell drug profiling identifies p53-linked vulnerabilities in refractory lymphoid malignancies

OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer

Atezolizumab Plus Chemotherapy Improves PFS in dMMR/MSI-H Metastatic CRC

FDA Advisory Committee Backs RP1/Nivolumab for Advanced Melanoma

Patient cell drug profiling identifies p53-linked vulnerabilities in refractory lymphoid malignancies

OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer

Atezolizumab Plus Chemotherapy Improves PFS in dMMR/MSI-H Metastatic CRC

FDA Advisory Committee Backs RP1/Nivolumab for Advanced Melanoma

Latest Post

Patient cell drug profiling identifies p53-linked vulnerabilities in refractory lymphoid malignancies

OTUD6A promotes de novo pyrimidine synthesis by deubiquitinating and stabilizing CAD in cervical cancer

Atezolizumab Plus Chemotherapy Improves PFS in dMMR/MSI-H Metastatic CRC

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Browsing: Ubiquitination