Dr. Ajai Chari and NP Samantha Shenoy review the design and long-term follow-up results of the MAIA trial and discuss their clinical implications for the management of newly diagnosed multiple myeloma (NDMM) in transplant-ineligible patients. The faculty examine key efficacy outcomes, including progression-free survival, overall survival, and minimal residual disease (MRD) negativity, while highlighting the continued deepening of responses observed with ongoing daratumumab-based therapy. Dr. Chari and NP Shenoy discuss the relevance of continuous treatment until disease progression, the durability of clinical benefit demonstrated with extended follow-up, and the applicability of the MAIA patient population to everyday clinical practice. The conversation also addresses safety and tolerability considerations associated with long-term treatment and explores how these findings have influenced frontline treatment decisions and expectations for sustained disease control in patients with NDMM.
