Dr. Ajai Chari and NP Samantha Shenoy introduce the program by reviewing the evolving treatment landscape in newly diagnosed multiple myeloma (NDMM) and discussing the factors that influence contemporary frontline treatment decisions. The faculty highlight the shift toward individualized treatment selection based on patient fitness, frailty, comorbidities, and treatment goals rather than transplant eligibility alone. They explore the growing incorporation of CD38-targeted therapies into frontline treatment strategies, the increasing emphasis on achieving deep and durable responses, and the importance of long-term disease control. Dr. Chari and NP Shenoy also discuss the expanding role of quadruplet regimens, minimal residual disease (MRD) assessment, and treatment duration considerations as part of modern NDMM management. The conversation establishes the clinical context for the subsequent review of MAIA and CEPHEUS trial data and their implications for everyday practice.
