Li Y, Liu F, Cai Q, Deng L, Ouyang Q, Zhang XH, et al. Invasion and metastasis in cancer: molecular insights and therapeutic targets. Signal Transduct Target Ther. 2025;10:57.
Google Scholar
Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target Ther. 2023;8:198.
Google Scholar
Kolarzyk AM, Kwon Y, Oh E, Lee KJ, Cho SY, Cano I, et al. Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasation. Mol Cancer. 2025;24:188.
Google Scholar
Moore MJ, Hamm J, Dancey J, Eisenberg PD, Dagenais M, Fields A, et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2003;21:3296–302.
Google Scholar
Wei Q, Qian Y, Yu J, Wong CC. Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications. Oncogene. 2020;39:6139–56.
Google Scholar
Tong H, Jiang Z, Song L, Tan K, Yin X, He C, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36:2493–510.e9.
Google Scholar
Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023;186:1564–79.
Google Scholar
Naxerova K. Evolutionary paths towards metastasis. Nat Rev Cancer. 2025;25:545–60.
Google Scholar
Lambert AW, Zhang Y, Weinberg RA. Cell-intrinsic and microenvironmental determinants of metastatic colonization. Nat Cell Biol. 2024;26:687–97.
Google Scholar
Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147:275–92.
Google Scholar
Mahmoud A, Ganesh K. Mouse models of metastasis and dormancy. Cold Spring Harb Perspect Med. 2024;14:a041386.
Google Scholar
Massagué J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature. 2016;529:298–306.
Google Scholar
Astuti Y, Raymant M, Quaranta V, Clarke K, Abudula M, Smith O, et al. Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nat Cancer. 2024;5:774–90.
Google Scholar
Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer. 2021;21:541–57.
Google Scholar
Xia L, Oyang L, Lin J, Tan S, Han Y, Wu N, et al. The cancer metabolic reprogramming and immune response. Mol Cancer. 2021;20:28.
Google Scholar
Gong Z, Li Q, Shi J, Liu ET, Shultz LD, Ren G. Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells. Cell Metab. 2022;34:1960–76.e9.
Google Scholar
Huh HD, Sub Y, Oh J, Kim YE, Lee JY, Kim HR, et al. Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination. Mol Cancer. 2023;22:63.
Google Scholar
Wu CY, Huang CX, Lao XM, Zhou ZW, Jian JH, Li ZX, et al. Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL. Cell. 2025;188:5701–16.e19.
Google Scholar
Wang S, Kuang J, Zhang H, Chen W, Zheng X, Wang J, et al. Bile acid-microbiome interaction promotes gastric carcinogenesis. Adv Sci. 2022;9:e2200263.
Google Scholar
Liu Z, Shi Y, Lv L, Chen J, Jiang W, Li J, et al. Small molecular inhibitors reverse cancer metastasis by blockading oncogenic PITPNM3. Adv Sci. 2022;9:e2204649.
Google Scholar
Liu YM, Ge JY, Chen YF, Liu T, Chen L, Liu CC, et al. Combined single-cell and spatial transcriptomics reveal the metabolic evolvement of breast cancer during early dissemination. Adv Sci. 2023;10:e2205395.
Google Scholar
Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, et al. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023;614:349–57.
Google Scholar
Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah SA. The role of lipids in cancer progression and metastasis. Cell Metab. 2022;34:1675–99.
Google Scholar
Nirmal AJ, Maliga Z, Vallius T, Quattrochi B, Chen AA, Jacobson CA, et al. The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution. Cancer Discov. 2022;12:1518–41.
Google Scholar
Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science. 2017;358:941–6.
Google Scholar
Li J, Duran MA, Dhanota N, Chatila WK, Bettigole SE, Kwon J, et al. Metastasis and immune evasion from extracellular cGAMP hydrolysis. Cancer Discov. 2021;11:1212–27.
Google Scholar
Chen X, Wu H, Liu Y, Liu L, Houser SR, Wang WE. Metabolic reprogramming: a byproduct or a driver of cardiomyocyte proliferation? Circulation. 2024;149:1598–610.
Google Scholar
Terry AR, Nogueira V, Rho H, Ramakrishnan G, Li J, Kang S, et al. CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression. Cell Metab. 2023;35:2060–76.e9.
Google Scholar
Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, et al. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell Metab. 2021;33:2040–58.e10.
Google Scholar
Parida PK, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, et al. Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases. Nat Cancer. 2023;4:893–907.
Google Scholar
Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, et al. Lactate metabolism in human lung tumors. Cell. 2017;171:358–71.e9.
Google Scholar
Fendt SM. 100 years of the Warburg effect: a cancer metabolism endeavor. Cell. 2024;187:3824–8.
Google Scholar
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, et al. NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. Cell Metab. 2021;33:2380–97.e9.
Google Scholar
Wang T, Sun F, Li C, Nan P, Song Y, Wan X, et al. MTA1, a novel ATP synthase complex modulator, enhances colon cancer liver metastasis by driving mitochondrial metabolism reprogramming. Adv Sci. 2023;10:e2300756.
Google Scholar
Claps G, Faouzi S, Quidville V, Chehade F, Shen S, Vagner S, et al. The multiple roles of LDH in cancer. Nat Rev Clin Oncol. 2022;19:749–62.
Google Scholar
Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, et al. Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Nat Commun. 2024;15:1987.
Google Scholar
Sun W, Jia M, Feng Y, Cheng X. Lactate is a bridge linking glycolysis and autophagy through lactylation. Autophagy. 2023;19:3240–1.
Google Scholar
Wang F, Chen L, Kong D, Zhang X, Xia S, Liang B, et al. Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex. Hepatology. 2024;79:606–23.
Google Scholar
LeBleu VS, O’Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, et al. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014;16:992–1003.
Google Scholar
Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T cell migration is dependent on glucokinase-mediated glycolysis. Immunity. 2017;47:875–89.e10.
Google Scholar
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, et al. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature. 2016;537:544–7.
Google Scholar
Alkan HF, Vesely PW, Hackl H, Foßelteder J, Schmidt DR, Vander Heiden MG, et al. Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis. Cancer Metab. 2020;8:26.
Google Scholar
Andolino C, Cotul EK, Xianyu Z, Li Y, Bhat D, Ayers M, et al. Fatty acid synthase-derived lipid stores support breast cancer metastasis. Cancer Metab. 2025;13:35.
Google Scholar
Xiao J, Cao S, Wang J, Li P, Cheng Q, Zhou X, et al. Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer. Cancer Commun. 2024;44:855–78.
Google Scholar
Wang Y, Hu M, Cao J, Wang F, Han JR, Wu TW, et al. ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization. Cell. 2025;188:412–29.e27.
Google Scholar
Chen J, Yu X, Yang G, Chen X, Gong C, Han L, et al. Combined blockade of lipid uptake and synthesis by CD36 inhibitor and SCD1 siRNA is beneficial for the treatment of refractory prostate cancer. Adv Sci. 2025;12:e2412244.
Google Scholar
Qiu Y, Wang X, Sun Y, Jin T, Tang R, Zhou X, et al. ACSL4-mediated membrane phospholipid remodeling induces integrin β1 activation to facilitate triple-negative breast cancer metastasis. Cancer Res. 2024;84:1856–71.
Google Scholar
Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572:402–6.
Google Scholar
Schwab A, Rao Z, Zhang J, Gollowitzer A, Siebenkäs K, Bindel N, et al. Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. Nat Cell Biol. 2024;26:1470–81.
Google Scholar
Li J, Wang X, Shi L, Liu B, Sheng Z, Chang S, et al. A mammalian conserved circular RNA CircLARP1B regulates hepatocellular carcinoma metastasis and lipid metabolism. Adv Sci. 2024;11:e2305902.
Google Scholar
Yang P, Qin H, Li Y, Xiao A, Zheng E, Zeng H, et al. CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis. Nat Commun. 2022;13:5782.
Google Scholar
Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, et al. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019;569:73–8.
Google Scholar
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2017;541:41–5.
Google Scholar
Huang B, Wang H, Liu S, Hao M, Luo D, Zhou Y, et al. Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis. Nat Commun. 2025;16:867.
Google Scholar
Yang M, Vousden KH. Serine and one-carbon metabolism in cancer. Nat Rev Cancer. 2016;16:650–62.
Google Scholar
Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, et al. SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun. 2023;14:3673.
Google Scholar
He D, Feng H, Sundberg B, Yang J, Powers J, Christian AH, et al. Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Mol Cell. 2022;82:3045–60.e11.
Google Scholar
Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, et al. The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment. Nat Commun. 2025;16:333.
Google Scholar
Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, et al. Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction. Cancer Commun. 2024;44:1261–86.
Google Scholar
Xu F, Ren Y, Teng Y, Mu J, Tang J, Sundaram K, et al. Tryptophan as a new member of RNA-induced silencing complexes prevents colon cancer liver metastasis. Adv Sci. 2024;11:e2307937.
Google Scholar
Rhoads JM, Chen W, Gookin J, Wu GY, Fu Q, Blikslager AT, et al. Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism. Gut. 2004;53:514–22.
Google Scholar
Doglioni G, Fernández-García J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, et al. Aspartate signalling drives lung metastasis via alternative translation. Nature. 2025;638:244–50.
Google Scholar
Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, et al. Asparagine bioavailability governs metastasis in a model of breast cancer. Nature. 2018;554:378–81.
Google Scholar
Di Russo S, Borsatti GE, Bouzidi A, Liberati FR, Riva A, Tripodi F, et al. NF-κB-mediated cytokine secretion and glutamate metabolic reprogramming converge in breast cancer brain tropism. Cancer Lett. 2025;630:217907.
Google Scholar
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, et al. Non-canonical glutamate-cysteine ligase activity protects against ferroptosis. Cell Metab. 2021;33:174–89.e7.
Google Scholar
Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, et al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020;22:476–86.
Google Scholar
Ryu KW, Fung TS, Baker DC, Saoi M, Park J, Febres-Aldana CA, et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature. 2024;635:746–54.
Google Scholar
Bai J, Liu T, Tu B, Yuan M, Shu Z, Fan M, et al. Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis. Autophagy. 2023;19:632–43.
Google Scholar
Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, et al. Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism. Sci Adv. 2024;10:eadq0355.
Google Scholar
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, et al. Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nat Metab. 2022;4:693–710.
Google Scholar
Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. 2013;493:542–6.
Google Scholar
Lu Y, Zhu J, Zhang Y, Li W, Xiong Y, Fan Y, et al. Lactylation-driven IGF2BP3-mediated serine metabolism reprogramming and RNA m6A-modification promotes lenvatinib resistance in HCC. Adv Sci. 2024;11:e2401399.
Google Scholar
Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, et al. Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction. Sci Adv. 2022;8:eabm9427.
Google Scholar
Nanda S, Calderon A, Sachan A, Duong TT, Koch J, Xin X, et al. Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cycles. Nat Commun. 2023;14:8356.
Google Scholar
Mullen NJ, Singh PK. Nucleotide metabolism: a pan-cancer metabolic dependency. Nat Rev Cancer. 2023;23:275–94.
Google Scholar
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, et al. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 2023;35:487–503.e7.
Google Scholar
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, et al. MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis. Nat Commun. 2023;14:4829.
Google Scholar
Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, et al. G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv. 2022;8:eabo0404.
Google Scholar
Tang B, Zhu J, Wang Y, Chen W, Fang S, Mao W, et al. Targeted xCT-mediated ferroptosis and protumoral polarization of macrophages is effective against HCC and enhances the efficacy of the anti-PD-1/L1 response. Adv Sci. 2023;10:e2203973.
Google Scholar
Pan BS, Hsu CC, Wu HE, Chen YR, Zhou X, Wang SC, et al. Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting. J Biomed Sci. 2025;32:71.
Google Scholar
De Leo A, Ugolini A, Yu X, Scirocchi F, Scocozza D, Peixoto B, et al. Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma. Immunity. 2024;57:1105–23.e8.
Google Scholar
Shi Q, Shen Q, Liu Y, Shi Y, Huang W, Wang X, et al. Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance. Cancer Cell. 2022;40:1207–22.e10.
Google Scholar
Liang Y, Ye F, Luo D, Long L, Wang Y, Jin Y, et al. Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer. Mol Cancer. 2024;23:125.
Google Scholar
Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, et al. Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments. Cancer Cell. 2022;40:201–18.e9.
Google Scholar
Cai L, Hammond NG, Tasdogan A, Alsamraae M, Yang C, Cameron RB, et al. High glucose contribution to the TCA cycle is a feature of aggressive non-small cell lung cancer in patients. Cancer Discov. 2025;15:702–16.
Google Scholar
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127–31.
Google Scholar
Bergers G, Fendt SM. The metabolism of cancer cells during metastasis. Nat Rev Cancer. 2021;21:162–80.
Google Scholar
Chen J, Huang Z, Chen Y, Tian H, Chai P, Shen Y, et al. Lactate and lactylation in cancer. Signal Transduct Target Ther. 2025;10:38.
Google Scholar
Han H, Wang S, Ma L, Yin H, Cheng X, Wang Y, et al. ASH2L-K312-Lac stimulates angiogenesis in tumors to expedite the malignant progression of hepatocellular carcinoma. Adv Sci. 2025;12:e09477.
Google Scholar
Shen H, Liu B, He J, Zhao W, Li W, Ma L, et al. Lactate metabolic reprogramming mediated by CircRNA-LDHA complex facilitates innate immune evasion of liver cancer. Adv Sci. 2025;12:e09989.
Google Scholar
Zhang X, Bai J, Sun S, Li Y, Li X, Meng G, et al. Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for effective photodynamic immunotherapy. Biomaterials. 2025;319:123203.
Google Scholar
Chen G, Lin L, Mai Z, Tang Y, Zhang Q, Chen G, et al. Carrier-free photodynamic bioregulators inhibiting lactic acid efflux combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy. ACS Nano. Accessed July 21, 2024.
Dupuy F, Tabariès S, Andrzejewski S, Dong Z, Blagih J, Annis MG, et al. PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer. Cell Metab. 2015;22:577–89.
Google Scholar
Zhang GF, Jensen MV, Gray SM, El K, Wang Y, Lu D, et al. Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion. Cell Metab. 2021;33:804–17.e5.
Google Scholar
Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, et al. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021;593:282–8.
Google Scholar
Li Y, Li B, Xu Y, Qian L, Xu T, Meng G, et al. GOT2 silencing promotes reprogramming of glutamine metabolism and sensitizes hepatocellular carcinoma to glutaminase inhibitors. Cancer Res. 2022;82:3223–35.
Google Scholar
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, et al. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021;53:16–26.
Google Scholar
Tan Z, Boyapati K, Tressler CM, Jenkinson NM, Glunde K. Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway. Cancer Lett. 2024;586:216653.
Google Scholar
Recouvreux MV, Moldenhauer MR, Galenkamp KMO, Jung M, James B, Zhang Y, et al. Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. J Exp Med. 2020;217:e20200388.
Google Scholar
Liu X, Qin H, Li Z, Lv Y, Feng S, Zhuang W, et al. Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway. Eur Respir J. 2022;60:2200062.
Google Scholar
Han Y, Pu Y, Liu X, Liu Z, Chen Y, Tang L, et al. YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner. Cancer Lett. 2024;601:217186.
Google Scholar
Yang J, Chen F, Lang L, Yang F, Fu Z, Martinez J, et al. Therapeutic targeting of the GLS1-c-Myc positive feedback loop suppresses glutaminolysis and inhibits progression of head and neck cancer. Cancer Res. 2024;84:3223–34.
Google Scholar
Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, et al. Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells. J Clin Invest. 2020;130:3865–84.
Google Scholar
Shen L, Wang S, Gao C, Li Q, Feng S, Sun W, et al. Tumour-associated macrophages serve as an acetate reservoir to drive hepatocellular carcinoma metastasis. Nat Metab. 2025;7:2268–83.
Google Scholar
Miller KD, O’Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, et al. Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer. Nat Cancer. 2023;4:1491–507.
Google Scholar
Hlavaty SI, Salcido KN, Pniewski KA, Mukha D, Ma W, Kannan T, et al. ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis. Cell Rep. 2024;43:114988.
Google Scholar
Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, et al. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024;26:613–27.
Google Scholar
Ma S, Dahabieh MS, Mann TH, Zhao S, McDonald B, Song WS, et al. Nutrient-driven histone code determines exhausted CD8(+) T cell fates. Science. 2025;387:eadj3020.
Google Scholar
Hu C, Xu B, Wang X, Wan WH, Lu J, Kong D, et al. Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC. Hepatology. 2023;77:48–64.
Google Scholar
Yang Z, Zou S, Zhang Y, Zhang J, Zhang P, Xiao L, et al. ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nat Commun. 2023;14:4193.
Google Scholar
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, et al. CuO nanozymes catalyze cysteine and glutathione depletion induced ferroptosis and cuproptosis for synergistic tumor therapy. Small. 2024;20:e2400326.
Google Scholar
Liu S, Chen JH, Li LC, Ye ZP, Liu JN, Chen YH, et al. Susceptibility of mitophagy-deficient tumors to ferroptosis induction by relieving the suppression of lipid peroxidation. Adv Sci. 2025;12:e2412593.
Google Scholar
Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, et al. P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis. Oncogene. 2021;40:6049–56.
Google Scholar
Pilley SE, Hennequart M, Vandekeere A, Blagih J, Legrave NM, Fendt SM, et al. Loss of attachment promotes proline accumulation and excretion in cancer cells. Sci Adv. 2023;9:eadh2023.
Google Scholar
Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, et al. Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. Nat Commun. 2017;8:15267.
Google Scholar
Cui B, He B, Huang Y, Wang C, Luo H, Lu J, et al. Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. Cell Death Dis. 2023;14:682.
Google Scholar
Xiong G, Stewart RL, Chen J, Gao T, Scott TL, Samayoa LM, et al. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. Nat Commun. 2018;9:4456.
Google Scholar
Navas LE, Carnero A. NAD(+) metabolism, stemness, the immune response, and cancer. Signal Transduct Target Ther. 2021;6:2.
Google Scholar
Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, et al. Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 2014;26:826–39.
Google Scholar
Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, et al. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023;24:2042–52.
Google Scholar
Zhang XY, Shi JB, Jin SF, Wang RJ, Li MY, Zhang ZY, et al. Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape. Cancer Commun. 2024;44:670–94.
Google Scholar
Xu H, Hu C, Wang Y, Shi Y, Yuan L, Xu J, et al. Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism. Oncogene. 2023;42:1994–2006.
Google Scholar
Fong W, Li Q, Ji F, Liang W, Lau HCH, Kang X, et al. Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis. Gut. 2023;72:2272–85.
Google Scholar
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, et al. Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance. Exp Mol Med. 2025;57:1089–105.
Google Scholar
Sun H, Li L, Li W, Yang F, Zhang Z, Liu Z, et al. p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth. EMBO Rep. 2021;22:e52537.
Google Scholar
Wan S, He QY, Yang Y, Liu F, Zhang X, Guo X, et al. SPARC stabilizes ApoE to induce cholesterol-dependent invasion and sorafenib resistance in hepatocellular carcinoma. Cancer Res. 2024;84:1872–88.
Google Scholar
Zeng Y, Luo Y, Zhao K, Liu S, Wu K, Wu Y, et al. m6A-mediated induction of 7-dehydrocholesterol reductase stimulates cholesterol synthesis and cAMP signaling to promote bladder cancer metastasis. Cancer Res. 2024;84:3402–18.
Google Scholar
Hu B, Zou T, Qin W, Shen X, Su Y, Li J, et al. Inhibition of EGFR overcomes acquired lenvatinib resistance driven by STAT3-ABCB1 signaling in hepatocellular carcinoma. Cancer Res. 2022;82:3845–57.
Google Scholar
Liu W, Chakraborty B, Safi R, Kazmin D, Chang CY, McDonnell DP. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nat Commun. 2021;12:5103.
Google Scholar
Sun M, Garnier L, Chevalier R, Roumain M, Wang C, Angelillo J, et al. Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma. Nat Commun. 2025;16:1217.
Google Scholar
Yarmolinsky J, Bull CJ, Vincent EE, Robinson J, Walther A, Smith GD, et al. Association between genetically proxied inhibition of HMG-CoA reductase and epithelial ovarian cancer. JAMA. 2020;323:646–55.
Google Scholar
Geng F, Guo D. SREBF1/SREBP-1 concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis and tumor growth. Autophagy. 2024;20:1183–5.
Google Scholar
Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, et al. Glucose-mediated N-glycosylation of SCAP is essential for SREBP-1 activation and tumor growth. Cancer Cell. 2015;28:569–81.
Google Scholar
Li J, Gu D, Lee SS, Song B, Bandyopadhyay S, Chen S, et al. Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene. 2016;35:6378–88.
Google Scholar
Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, et al. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature. 2016;531:651–5.
Google Scholar
Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, et al. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016;18:561–71.
Google Scholar
Hu XK, Rao SS, Tan YJ, Yin H, Luo MJ, Wang ZX, et al. Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK. Theranostics. 2020;10:7710–29.
Google Scholar
Yan H, Wang Z, Teng D, Chen X, Zhu Z, Chen H, et al. Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth. Cell Metab. 2024;36:2449–67.e6.
Google Scholar
Zhang Y, Yu X, Bao R, Huang H, Gu C, Lv Q, et al. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses. Cell Metab. 2023;35:2107–18.e6.
Google Scholar
Feng T, Luo Q, Liu Y, Jin Z, Skwarchuk D, Lee R, et al. Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD. Nat Metab. 2025;7:2018–2032.
Google Scholar
Xiong Z, Yang L, Zhang C, Huang W, Zhong W, Yi J, et al. MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation. Autophagy. 2025;21:80–101.
Google Scholar
Wang Q, Song X, Zhang Y, Liang S, Zhang M, Wang H, et al. A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma. Cell Rep. 2024;43:114550.
Google Scholar
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, et al. ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system. Theranostics. 2020;10:12044–59.
Google Scholar
Culbertson B, Garcia K, Markett D, Asgharian H, Chen L, Fish L, et al. A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression. Nat Cancer. 2023;4:682–98.
Google Scholar
Sim N, Carter JM, Deka K, Tan BKT, Sim Y, Tan SM, et al. TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancer. Nat Commun. 2024;15:5638.
Google Scholar
Frau M, Feo F, Pascale RM. Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. J Hepatol. 2013;59:830–41.
Google Scholar
Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, et al. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest. 2021;131:e146187.
Google Scholar
Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, et al. Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts. Gut. 2023;72:501–11.
Google Scholar
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005;7:77–85.
Google Scholar
Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, et al. Cancer-derived succinate promotes macrophage polarization and cancer metastasis via succinate receptor. Mol Cell. 2020;77:213–27.e5.
Google Scholar
Atlante S, Visintin A, Marini E, Savoia M, Dianzani C, Giorgis M, et al. α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis. Cell Death Dis. 2018;9:756.
Google Scholar
Bao Y, Qiao J, Gong W, Zhang R, Zhou Y, Xie Y, et al. Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway. Acta Pharm Sin B. 2024;14:4461–77.
Google Scholar
Patel R, Ford CA, Rodgers L, Rushworth LK, Fleming J, Mui E, et al. Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Res. 2022;82:2565–75.
Google Scholar
Zhang L, Zhu Z, Yan H, Wang W, Wu Z, Zhang F, et al. Creatine promotes cancer metastasis through activation of Smad2/3. Cell Metab. 2021;33:1111–23.e4.
Google Scholar
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016;536:479–83.
Google Scholar
Li W, Zeng Q, Wang B, Lv C, He H, Yang X, et al. Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 2024;76:103335.
Google Scholar
Qian L, Li N, Lu XC, Xu M, Liu Y, Li K, et al. Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression. Nat Metab. 2023;5:1159–73.
Google Scholar
Gusarov I, Shamovsky I, Pani B, Gautier L, Eremina S, Katkova-Zhukotskaya O, et al. Dietary thiols accelerate aging of C. elegans. Nat Commun. 2021;12:4336.
Google Scholar
Auf der Maur P, Trefny MP, Baumann Z, Vulin M, Correia AL, Diepenbruck M, et al. N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer. Cell Rep Med. 2023;4:101002.
Google Scholar
Huang Z, Hu H. Arginine deiminase induces immunogenic cell death and is enhanced by N-acetylcysteine in murine MC38 colorectal cancer cells and MDA-MB-231 human breast cancer cells in vitro. Molecules. 2021;26:511.
Google Scholar
Feng H, Moriyama T, Ohuchida K, Sheng N, Iwamoto C, Shindo K, et al. N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions. J Exp Clin Cancer Res. 2021;40:133.
Google Scholar
Kashif M, Yao H, Schmidt S, Chen X, Truong M, Tüksammel E, et al. ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis. Redox Biol. 2023;60:102619.
Google Scholar
Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, et al. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 2015;527:186–91.
Google Scholar
Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, et al. BACH1 stabilization by antioxidants stimulates lung cancer metastasis. Cell. 2019;178:330–45.e22.
Google Scholar
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci USA. 2008;105:11105–9.
Google Scholar
Zhao H, Fu W, Yang X, Zhang W, Wu S, Ma J, et al. High-dose vitamin C: a promising anti-tumor agent, insight from mechanisms, clinical research, and challenges. Genes Dis. 2026;13:101742.
Google Scholar
Hoppe C, Freuding M, Büntzel J, Münstedt K, Hübner J. Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases. J Cancer Res Clin Oncol. 2021;147:3025–42.
Google Scholar
Zhang X, Li S, He J, Jin Y, Zhang R, Dong W, et al. TET2 suppresses VHL deficiency-driven clear cell renal cell carcinoma by inhibiting HIF signaling. Cancer Res. 2022;82:2097–109.
Google Scholar
He X, Wang Q, Cheng X, Wang W, Li Y, Nan Y, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025;188:1858–77.e21.
Google Scholar
Zhang J, Zhang Q, Lin G, Wang Y, Li J, Wang P, et al. Single-cell analysis reveals that vitamin C inhibits bone metastasis of renal cancer via cell cycle arrest and microenvironment remodeling. Adv Sci. 2025;12:e01011.
Google Scholar
Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, et al. Antioxidants stimulate BACH1-dependent tumor angiogenesis. J Clin Invest. 2023;133:e169671.
Google Scholar
Yu Y, Xie B, Wang J, Luo W, Yang M, Xiong Z, et al. Translational selenium nanoparticles promotes clinical non-small-cell lung cancer chemotherapy via activating selenoprotein-driven immune manipulation. Adv Mater. 2025;37:e2415818.
Google Scholar
Xu Y, Lai H, Pan S, Pan L, Liu T, Yang Z, et al. Selenium promotes immunogenic radiotherapy against cervical cancer metastasis through evoking P53 activation. Biomaterials. 2024;305:122452.
Google Scholar
Zhou JN, Zhang B, Wang HY, Wang DX, Zhang MM, Zhang M, et al. A functional screening identifies a new organic selenium compound targeting cancer stem cells: role of c-Myc transcription activity inhibition in liver cancer. Adv Sci. 2022;9:e2201166.
Google Scholar
He J, Wang Y, Ren Y, Yuan Q, Zhang Z, Li L, et al. Calcium-mediated cell adhesion enhancement-based antimetastasis and synergistic antitumor therapy by conjugated polymer-calcium composite nanoparticles. ACS Nano. 2024;18:24953–67.
Google Scholar
Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res. 2020;30:966–79.
Google Scholar
Zhang Z, Sun X, Qin Y, Yang Y, Dai Q, Bao X, et al. Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy. J Nanobiotechnology. 2025;24:75.
Google Scholar
Huang X, Zhuang J, Teng X, Li L, Chen D, Yan X, et al. The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species. Biomaterials. 2010;31:6142–53.
Google Scholar
Yang Y, Chen F, Xu N, Yao Q, Wang R, Xie X, et al. Red-light-triggered self-destructive mesoporous silica nanoparticles for cascade-amplifying chemo-photodynamic therapy favoring antitumor immune responses. Biomaterials. 2022;281:121368.
Google Scholar
Li B, Tian J, Zhang F, Wu C, Li Z, Wang D, et al. Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment. Nat Commun. 2024;15:9417.
Google Scholar
Rao E, Hou Y, Huang X, Wang L, Wang J, Zheng W, et al. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Sci Immunol. 2021;6:eaba8426.
Google Scholar
Singh DK, Carcamo S, Farias EF, Hasson D, Zheng W, Sun D, et al. 5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling. Cell Rep. 2023;42:112560.
Google Scholar
Biswas AK, Han S, Tai Y, Ma W, Coker C, Quinn SA, et al. Targeting S100A9-ALDH1A1-retinoic acid signaling to suppress brain relapse in EGFR-mutant lung cancer. Cancer Discov. 2022;12:1002–21.
Google Scholar
Li JT, Yang H, Lei MZ, Zhu WP, Su Y, Li KY, et al. Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA. Signal Transduct Target Ther. 2022;7:192.
Google Scholar
Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun. 2014;5:3128.
Google Scholar
Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, O’Connor RS, et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun. 2021;12:877.
Google Scholar
Lamm N, Maoz K, Bester AC, Im MM, Shewach DS, Karni R, et al. Folate levels modulate oncogene-induced replication stress and tumorigenicity. EMBO Mol Med. 2015;7:1138–52.
Google Scholar
Kim YS, Lee HA, Lim JY, Kim Y, Jung CH, Yoo SH, et al. β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α. J Nutr Biochem. 2014;25:655–64.
Google Scholar
Guruvayoorappan C, Kuttan G. Beta-carotene inhibits tumor-specific angiogenesis by altering the cytokine profile and inhibits the nuclear translocation of transcription factors in B16F-10 melanoma cells. Integr Cancer Ther. 2007;6:258–70.
Google Scholar
Bae S, Lim JW, Kim H. β-carotene inhibits expression of matrix metalloproteinase-10 and invasion in helicobacter pylori-infected gastric epithelial cells. Molecules. 2021;26:1567.
Google Scholar
Lu L, Chen J, Li M, Tang L, Wu R, Jin L, et al. β‑carotene reverses tobacco smoke‑induced gastric EMT via Notch pathway in vivo. Oncol Rep. 2018;39:1867–73.
Google Scholar
Yi EY, Kim YJ. Betaine inhibits in vitro and in vivo angiogenesis through suppression of the NF-κB and Akt signaling pathways. Int J Oncol. 2012;41:1879–85.
Google Scholar
Wang C, Li MC, Huang WG, Huang SY, Wusiman M, Liu ZY, et al. Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m(6)A/YTHDF1-mediated enhancement on ATG3 stability. Theranostics. 2025;15:1949–65.
Google Scholar
Li T, Zhao N, Lu J, Zhu Q, Liu X, Hao F, et al. Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways. Bioengineered. 2019;10:282–91.
Google Scholar
Huang C, Wang SH, Liu TT, Wu MY, Cai KN, Xie ZH, et al. Epigallocatechin gallate derivative Y(6) reverses oxaliplatin resistance in hepatocellular carcinoma via targeting the MiR-338-3p/HIF-1α/TWIST axis to inhibit EMT. Recent Pat Anticancer Drug Discov. 2025;20:753–64.
Google Scholar
Han Y, Wang Q, Fan X, Chu J, Peng J, Zhu Y, et al. Epigallocatechin gallate attenuates overload‑induced cardiac ECM remodeling via restoring T cell homeostasis. Mol Med Rep. 2017;16:3542–50.
Google Scholar
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, et al. Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells. Biochem Biophys Res Commun. 2017;482:15–21.
Google Scholar
Masuda M, Suzui M, Lim JT, Weinstein IB. Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells. Clin Cancer Res. 2003;9:3486–91.
Google Scholar
Kirane A, Ludwig KF, Sorrelle N, Haaland G, Sandal T, Ranaweera R, et al. Warfarin blocks Gas6-mediated Axl activation required for pancreatic cancer epithelial plasticity and metastasis. Cancer Res. 2015;75:3699–705.
Google Scholar
Swamynathan MM, Kuang S, Watrud KE, Doherty MR, Gineste C, Mathew G, et al. Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function. Science. 2024;386:eadk9167.
Google Scholar
Wang SC, Sun HL, Hsu YH, Liu SH, Lii CK, Tsai CH, et al. α-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition. Biochem Pharmacol. 2020;180:114152.
Google Scholar
Roy S, Rawat AK, Sammi SR, Devi U, Singh M, Gautam S, et al. Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget. 2017;8:70049–71.
Google Scholar
Yoon S, Lee BK, Kim KP. Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer. Phytomedicine. 2023;121:155120.
Google Scholar
Liu Y, Liu Z, Hu Y, Ling Y, Qing S, Liu Y, et al. Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer. Nat Commun. 2025;16:5906.
Google Scholar
Moy RH, Nguyen A, Loo JM, Yamaguchi N, Kajba CM, Santhanam B, et al. Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization. Dev Cell. 2022;57:1146–59.e7.
Google Scholar
Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, et al. Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res. 2010;70:1173–83.
Google Scholar
Lin TY, Lu MK, Chang CC. Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling. Int J Biol Macromol. 2020;157:311–8.
Google Scholar
Xia Y, Sun M, Huang H, Jin WL. Drug repurposing for cancer therapy. Signal Transduct Target Ther. 2024;9:92.
Google Scholar
Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, et al. Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1. Mol Cell. 2018;71:606–20.e7.
Google Scholar
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, et al. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021;33:1013–26.e6.
Google Scholar
Tong D, Liu Q, Liu G, Xu J, Lan W, Jiang Y, et al. Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis. Cancer Lett. 2017;389:23–32.
Google Scholar
Cai S, Chen Z, Wang Y, Wang M, Wu J, Tong Y, et al. Reducing PD-L1 expression with a self-assembled nanodrug: an alternative to PD-L1 antibody for enhanced chemo-immunotherapy. Theranostics. 2021;11:1970–81.
Google Scholar
Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. The interplay between cell signalling and the mevalonate pathway in cancer. Nat Rev Cancer. 2016;16:718–31.
Google Scholar
Yang Z, Su Z, DeWitt JP, Xie L, Chen Y, Li X, et al. Fluvastatin prevents lung adenocarcinoma bone metastasis by triggering autophagy. EBioMedicine. 2017;19:49–59.
Google Scholar
Kortüm B, Radhakrishnan H, Zincke F, Sachse C, Burock S, Keilholz U, et al. Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis. Oncogene. 2022;41:4446–58.
Google Scholar
Cole AJ, Fayomi AP, Anyaeche VI, Bai S, Buckanovich RJ. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics. 2020;10:3083–98.
Google Scholar
Wang C, Zhang T, Liao Q, Dai M, Guo J, Yang X, et al. Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation. Protein Cell. 2021;12:128–44.
Google Scholar
Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS ONE. 2012;7:e48208.
Google Scholar
Yang J, Yamashita-Kanemaru Y, Morris BI, Contursi A, Trajkovski D, Xu J, et al. Aspirin prevents metastasis by limiting platelet TXA(2) suppression of T cell immunity. Nature. 2025;640:1052–61.
Google Scholar
Liao D, Zhong L, Duan T, Zhang RH, Wang X, Wang G, et al. Aspirin suppresses the growth and metastasis of osteosarcoma through the NF-κB pathway. Clin Cancer Res. 2015;21:5349–59.
Google Scholar
Zhou Y, Lin S, Zhong X, Huang F, Huang J, Xu L. Oleanolic acid combined with aspirin plays antitumor roles in colorectal cancer via the Akt/NFκB/IκBα/COX2 pathway. Cell Death Discov. 2024;10:504.
Google Scholar
Dunbar K, Valanciute A, Lima ACS, Vinuela PF, Jamieson T, Rajasekaran V, et al. Aspirin rescues Wnt-driven stem-like phenotype in human intestinal organoids and increases the Wnt antagonist Dickkopf-1. Cell Mol Gastroenterol Hepatol. 2021;11:465–89.
Google Scholar
Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, et al. Identification of a primary target of thalidomide teratogenicity. Science. 2010;327:1345–50.
Google Scholar
Ismail TM, Crick RG, Du M, Shivkumar U, Carnell A, Barraclough R, et al. Targeted destruction of S100A4 inhibits metastasis of triple negative breast cancer cells. Biomolecules. 2023;13:1099.
Google Scholar
Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014;343:305–9.
Google Scholar
Xia Y, Wang WC, Shen WH, Xu K, Hu YY, Han GH, et al. Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021;349:109652.
Google Scholar
Nieminen K, Immanen J, Laxell M, Kauppinen L, Tarkowski P, Dolezal K, et al. Cytokinin signaling regulates cambial development in poplar. Proc Natl Acad Sci USA. 2008;105:20032–7.
Google Scholar
Kurzeder C, Nguyen-Sträuli BD, Krol I, Ring A, Castro-Giner F, Nüesch M, et al. Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial. Nat Med. 2025;31:1120–4.
Google Scholar
Numata Y, Fujii T, Toda C, Okumura T, Manabe T, Takeda N, et al. Digoxin promotes anoikis of circulating cancer cells by targeting Na(+)/K(+)-ATPase α3-isoform. Cell Death Dis. 2025;16:373.
Google Scholar
Held IM. Climate science: the cause of the pause. Nature. 2013;501:318–9.
Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, et al. Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proc Natl Acad Sci USA. 2023;120:e2219199120.
Google Scholar
Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, et al. Losartan blocks osteosarcoma-elicited monocyte recruitment, and combined with the kinase inhibitor toceranib, exerts significant clinical benefit in canine metastatic osteosarcoma. Clin Cancer Res. 2022;28:662–76.
Google Scholar
Zou J, Zhou X, Ma Y, Yu R. Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad. Biomed Pharmacother. 2022;149:112931.
Google Scholar
Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007;7:599–612.
Google Scholar
Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, et al. AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal Transduct Target Ther. 2021;6:299.
Google Scholar
Wu Y, Adeel MM, Xia D, Sancar A, Li W. Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization. Nucleic Acids Res. 2024;52:11704–19.
Google Scholar
Crescimanno G, Modica R, Lo Mauro R, Musumeci O, Toscano A, Marrone O. Role of the cardio-pulmonary exercise test and six-minute walking test in the evaluation of exercise performance in patients with late-onset Pompe disease. Neuromuscul Disord. 2015;25:542–7.
Google Scholar
Chang TY, Lan KC, Wu CH, Sheu ML, Yang RS, Liu SH. Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness. Arch Toxicol. 2023;97:2231–44.
Google Scholar
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, et al. Role of glycated high mobility group box-1 in gastric cancer. Int J Mol Sci. 2021;22:5185.
Google Scholar
Christmann M, Boisseau C, Kitzinger R, Berac C, Allmann S, Sommer T, et al. Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations. Nucleic Acids Res. 2016;44:10727–43.
Google Scholar
Mu W, Gu P, Li H, Zhou J, Jian Y, Jia W, et al. Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis. Cancer Commun. 2024;44:718–38.
Google Scholar
Zhou Z, Dong D, Yuan Y, Luo J, Liu XD, Chen LY, et al. Single cell atlas reveals multilayered metabolic heterogeneity across tumour types. EBioMedicine. 2024;109:105389.
Google Scholar
Elia I, Haigis MC. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nat Metab. 2021;3:21–32.
Google Scholar
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008;118:3930–42.
Google Scholar
Keoh LQ, Chiu CF, Ramasamy TS. Metabolic plasticity and cancer stem cell metabolism: exploring the glycolysis-OXPHOS switch as a mechanism for resistance and tumorigenesis. Stem Cell Rev Rep. 2025;21:2446–68.
Google Scholar
Sinha S, Panda AK, Xavier das Neves R, Nwosu ZC, Xu K, van Beek E, et al. Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth. Cancer Discov. 2025;15:2344–2373.
Google Scholar
Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell. 2014;159:1603–14.
Google Scholar
Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, et al. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018;556:249–54.
Google Scholar
Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, et al. Nucleus-translocated ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Mol Cell. 2017;66:684–97.e9.
Google Scholar
Cheng J, Yan J, Liu Y, Shi J, Wang H, Zhou H, et al. Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8(+) T cells in the tumor microenvironment. Cell Metab. 2023;35:961–78.e10.
Google Scholar
Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, et al. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020;585:277–82.
Google Scholar
Han S, Bao X, Zou Y, Wang L, Li Y, Yang L, et al. d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma. Sci Adv. 2023;9:eadg2697.
Google Scholar
Yang S, Ma Y, Wu T, Huang X. Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression. Cell Death Dis. 2026;17:185.
Google Scholar
Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, et al. LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells. Cell Metab. 2016;24:657–71.
Google Scholar
Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, et al. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors. Immunity. 2021;54:1561–77.e7.
Google Scholar
Gu J, Li Y, Chen Q, Song Z, Qian Q, Liang Y, et al. Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity. Cell. 2026;189:418–34.e24.
Google Scholar
O’Brien BJ, Faraoni EY, Strickland LN, Ma Z, Mota V, Mota S, et al. CD73-generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis. FASEB J. 2023;37:e22684.
Google Scholar
Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, et al. IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression. Cell. 2020;182:1252–70.e34.
Google Scholar
Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, et al. Mettl3-mediated mRNA m(6)A methylation promotes dendritic cell activation. Nat Commun. 2019;10:1898.
Google Scholar
Liu JL, Xu X, Rixiati Y, Wang CY, Ni HL, Chen WS, et al. Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells. Cell Metab. 2024;36:1320–34.e9.
Google Scholar
Bersier L, Lorenzo-Martin LF, Chiang YH, Durot S, Czauderna A, Yarahmadov T, et al. Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state. Nat Commun. 2025;17:832.
Google Scholar
Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. 2018;360:eaan5931.
Google Scholar
Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, et al. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022;110:2268–82.e4.
Google Scholar
Prajnamitra RP, Beh CY, Tang WH, Ruan SC, Cheng YY, Kuo PT, et al. Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer. Theranostics. 2025;15:7693–708.
Google Scholar
Koh A, Mannerås-Holm L, Yunn NO, Nilsson PM, Ryu SH, Molinaro A, et al. Microbial imidazole propionate affects responses to metformin through p38γ-dependent inhibitory AMPK phosphorylation. Cell Metab. 2020;32:643–53.e4.
Google Scholar
Liao K, Wen J, Liu Z, Zhang B, Zhang X, Fu Y, et al. The role of intratumoral microbiome in the occurrence, proliferation, metastasis of colorectal cancer and its underlying therapeutic strategies. Ageing Res Rev. 2025;111:102820.
Google Scholar
Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, et al. Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021;12:4077.
Google Scholar
Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, et al. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 2021;374:1632–40.
Google Scholar
Chen L, Zhou X, Wang Y, Wang D, Ke Y, Zeng X. Propionate and butyrate produced by gut microbiota after probiotic supplementation attenuate lung metastasis of melanoma cells in mice. Mol Nutr Food Res. 2021;65:e2100096.
Google Scholar
Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017;358:1443–8.
Google Scholar
Zepeda-Rivera M, Minot SS, Bouzek H, Wu H, Blanco-Míguez A, Manghi P, et al. A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche. Nature. 2024;628:424–32.
Google Scholar
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018;359:91–7.
Google Scholar
Derosa L, Routy B, Thomas AM, Iebba V, Zalcman G, Friard S, et al. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer. Nat Med. 2022;28:315–24.
Google Scholar
Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, et al. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science. 2021;371:595–602.
Google Scholar
Su Z, Liu Y, Xia Z, Rustgi AK, Gu W. An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription. Sci Adv. 2024;10:eadm9481.
Google Scholar
Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, et al. Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer Cell. 2016;30:136–46.
Google Scholar
Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, et al. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell. 2022;40:720–37.e5.
Google Scholar
Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, et al. Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Nature. 2021;599:485–90.
Google Scholar
Ostendorf BN, Bilanovic J, Adaku N, Tafreshian KN, Tavora B, Vaughan RD, et al. Common germline variants of the human APOE gene modulate melanoma progression and survival. Nat Med. 2020;26:1048–53.
Google Scholar
Hu J, Yang L, Peng X, Mao M, Liu X, Song J, et al. ALDH2 hampers immune escape in liver hepatocellular carcinoma through ROS/Nrf2-mediated autophagy. Inflammation. 2022;45:2309–24.
Google Scholar
Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature. 2020;577:115–20.
Google Scholar
Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, et al. Lymph protects metastasizing melanoma cells from ferroptosis. Nature. 2020;585:113–8.
Google Scholar
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, et al. Fatty acid synthesis is required for breast cancer brain metastasis. Nat Cancer. 2021;2:414–28.
Google Scholar
Zou Y, Watters A, Cheng N, Perry CE, Xu K, Alicea GM, et al. Polyunsaturated fatty acids from astrocytes activate PPARγ signaling in cancer cells to promote brain metastasis. Cancer Discov. 2019;9:1720–35.
Google Scholar
Esquea E, Ciraku L, Young RG, Merzy J, Talarico AN, Rashad AA, et al. Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth. Preprint. bioRxiv. 2023 https://doi.org/10.1101/2023.12.22.573073.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, et al. Limited environmental serine and glycine confer brain metastasis sensitivity to PHGDH inhibition. Cancer Discov. 2020;10:1352–73.
Google Scholar
Peng C, Yang P, Zhang D, Jin C, Peng W, Wang T, et al. KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2. Acta Pharm Sin B. 2024;14:2959–76.
Google Scholar
Zuo Q, Mogol AN, Liu YJ, Santaliz Casiano A, Chien C, Drnevich J, et al. Targeting metabolic adaptations in the breast cancer-liver metastatic niche using dietary approaches to improve endocrine therapy efficacy. Mol Cancer Res. 2022;20:923–37.
Google Scholar
Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, et al. Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis. Cell Rep. 2016;17:837–48.
Google Scholar
Kim M, Cong H, Goettl R, Liu J, Fong KW. Bone metastatic progression of prostate cancer is regulated by TRIM28-LDHA-mediated metabolism. Mol Cancer Res. 2026;24:93–105.
Google Scholar
Dong J, Ding H, Wang S, Ruan S, Ye J, Hu P, et al. Targeting bone marrow adipocyte-driven fatty acid metabolism to overcome drug resistance in lung cancer bone metastasis. J Nanobiotechnology. 2025;23:709.
Google Scholar
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013–21.
Google Scholar
Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, et al. Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 2017;18:770–8.
Google Scholar
Kelly W, Diaz Duque AE, Michalek J, Konkel B, Caflisch L, Chen Y, et al. Phase II investigation of TVB-2640 (Denifanstat) with bevacizumab in patients with first relapse high-grade astrocytoma. Clin Cancer Res. 2023;29:2419–25.
Google Scholar
Lin HM, Mak B, Yeung N, Huynh K, Meikle TG, Mellett NA, et al. Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase. EBioMedicine. 2021;72:103625.
Google Scholar
Britten CD, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, et al. A phase I study of ABC294640, a first-in-class sphingosine kinase-2 inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2017;23:4642–50.
Google Scholar
Roboz GJ, DiNardo CD, Stein EM, de Botton S, Mims AS, Prince GT, et al. Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia. Blood. 2020;135:463–71.
Google Scholar
Casak SJ, Pradhan S, Fashoyin-Aje LA, Ren Y, Shen YL, Xu Y, et al. FDA approval summary: ivosidenib for the treatment of patients with advanced unresectable or metastatic, chemotherapy refractory cholangiocarcinoma with an IDH1 mutation. Clin Cancer Res. 2022;28:2733–7.
Google Scholar
Chen R, Hu T, Lu Y, Yang S, Zhang M, Tan C, et al. PAD4 inhibitor-loaded layered double hydroxide nanosheets as a multifunctional nanoplatform for photodynamic therapy-mediated tumor metastasis treatment. Small. 2024;20:e2404211.
Google Scholar
Haq ATA, Yang PP, Jin C, Shih JH, Chen LM, Tseng HY, et al. Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent relapse and metastasis of triple-negative breast cancer. Theranostics. 2024;14:2167–89.
Google Scholar
Halford S, Veal GJ, Wedge SR, Payne GS, Bacon CM, Sloan P, et al. A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer. Clin Cancer Res. 2023;29:1429–39.
Google Scholar
Li X, Zhang C, Mei Y, Zhong W, Fan W, Liu L, et al. Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair. Signal Transduct Target Ther. 2025;10:214.
Google Scholar
Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, et al. Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy. Cancer Cell. 2016;30:968–85.
Google Scholar
Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, et al. PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. Nature. 2022;605:747–53.
Google Scholar
Wei SJ, Schell JR, Chocron ES, Varmazyad M, Xu G, Chen WH, et al. Ketogenic diet induces p53-dependent cellular senescence in multiple organs. Sci Adv. 2024;10:eado1463.
Google Scholar
